Galina I. Lepesheva - Publications, H-index & Citations

Galina I. Lepesheva

vanderbilt university

40H指数

111论文数

5.0K被引数

收录论文 55

发表时间

Cryo-EM reveals an ensemble of cytochrome P450 reductase conformations in solution Cryo-em揭示了溶液中细胞色素P450还原酶构象的集合

Protein Science

IF5.2

2026-01-21

OAAI

Galina I. Lepesheva; Tatiana Y. Hargrove; Yi Ren

A bypass gateway from cholesterol to sex steroid biosynthesis circumnavigates CYP17A1 从胆固醇到性类固醇生物合成的一个旁路gateway绕过了CYP17A1

Nature Communications

IF15.7

2025-12-04

OAAI

Ziqi Zhu; Yoon-Mi Chung; Mohammad Alyamani; Yijing Dai; Kevin D. McCarty; Evan Roberts; Sunita Sinha; Jianneng Li; Xiuxiu Li; Emad M. Gad; Zhiqun Zhou; Jinyuan Shi; Robert A. Burgess; Tatiana Y. Hargrove; Galina I. Lepesheva; F. Peter Guengerich; Richard J. Auchus; Nima Sharifi

A First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant Candida albicans Strain, Computational Investigation and in Vivo Validation in a Galleria mellonella Fungal Infection Model

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-08-08

PREAI

Pelliccia, Sveva; Russomanno, Pasquale; Barone, Simona; Mateu, Baptiste; Alfano, Antonella Ilenia; Miranda, Martina; Coretti, Lorena; Lembo, Francesca; Piccolo, Marialuisa; Irace, Carlo; Friggeri, Laura; Hargrove, Tatiana Y.; Curtis, Aaron; Lepesheva, Galina I.; Kavanagh, Kevin; Buommino, Elisabetta; Brindisi, Margherita

Identification of Potent and Selective Inhibitors of Acanthamoeba: Structural Insights into Sterol 14α-Demethylase as a Key Drug Target

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-04-29

OAAI

Hargrove, Tatiana Y.; Lamb, David C.; Wawrzak, Zdzislaw; Hull, Marcus; Kelly, Steven L.; Guengerich, F. Peter; Lepesheva, Galina I.

Oxygen-18 Labeling Reveals a Mixed Fe-O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14α-Demethylation

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2024-01-24

OAAI

McCarty, Kevin D.; Tateishi, Yasuhiro; Hargrove, Tatiana Y.; Lepesheva, Galina I.; Guengerich, F. Peter

Structural modeling of cytochrome P450 51 from a deep-sea fish points to a novel structural feature in other CYP51s

JOURNAL OF INORGANIC BIOCHEMISTRY

IF3.2

2023-08-01

OAAI

Goldstone, Jared, V; Lamb, David C.; Kelly, Steven L.; Lepesheva, Galina I.; Stegeman, John J.

Processive kinetics in the three-step lanosterol 14α-demethylation reaction catalyzed by human cytochrome P450 51A1

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2023-07-01

OAAI

Mccarty, Kevin D.; Sullivan, Molly E.; Tateishi, Yasuhiro; Hargrove, Tatiana Y.; Lepesheva, Galina I.; Guengerich, F. Peter

Unravelling the role of transient redox partner complexes in P450 electron transfer mechanics

SCIENTIFIC REPORTS

IF3.9

2022-09-28

OAAI

Hargrove, Tatiana Y.; Lamb, David C.; Smith, Jarrod A.; Wawrzak, Zdzislaw; Kelly, Steven L.; Lepesheva, Galina, I

Relaxed Substrate Requirements of Sterol 14α-Demethylase from Naegleria fowleri Are Accompanied by Resistance to Inhibition

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-11-29

OAAI

Hargrove, Tatiana Y.; Wawrzak, Zdzislaw; Rachakonda, Girish; Nes, W. David; Villalta, Fernando; Guengerich, F. Peter; Lepesheva, Galina, I

Concerning P450 Evolution: Structural Analyses Support Bacterial Origin of Sterol 14α-Demethylases

MOLECULAR BIOLOGY AND EVOLUTION

IF5.3

2020-10-08

OAAI

Lamb, David C.; Hargrove, Tatiana Y.; Zhao, Bin; Wawrzak, Zdzislaw; Goldstone, Jared, V; Nes, William David; Kelly, Steven L.; Waterman, Michael R.; Stegeman, John J.; Lepesheva, Galina, I

The Clinically Approved Antifungal Drug Posaconazole Inhibits Human Cytomegalovirus Replication

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2020-09-21

OAAI

Mercorelli, Beatrice; Luganini, Anna; Celegato, Marta; Palu, Giorgio; Gribaudo, Giorgio; Lepesheva, Galina I.; Loregian, Arianna

A requirement for an active proton delivery network supports a compound I-mediated C?C bond cleavage in CYP51 catalysis

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2020-07-01

OAAI

Hargrove, Tatiana Y.; Wawrzak, Zdzislaw; Guengerich, F. Peter; Lepesheva, Galina, I

Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2019-10-30

OAAI

Friggeri, Laura; Hargrove, Tatiana Y.; Wawrzak, Zdzislaw; Guengerich, F. Peter; Lepesheva, Galina I.

Successful Aspects of the Coadministration of Sterol 14α-Demethylase Inhibitor VFV and Benznidazole in Experimental Mouse Models of Chagas Disease Caused by the Drug-Resistant Strain of Trypanosoma cruzi

ACS INFECTIOUS DISEASES

IF3.8

2019-01-09

OAAI

Guedes-da-Silva, Francisca Hildemagna; Jaen Batista, Denise da Gama; Da Silva, Cristiane Franca; Pavao, Beatriz Philot; Batista, Marcos Meuser; Moreira, Otacilio Cruz; Souza, Leticia Rocha Quintino; Britto, Constanca; Rachakonda, Girish; Villalta, Fernando; Lepesheva, Galina I.; Correia Soeiro, Maria de Nazare

Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2018-12-01

OAAI

Hargrove, Tatiana Y.; Wawrzak, Zdzislaw; Fisher, Paxtyn M.; Child, Stella A.; Nes, W. David; Guengerich, F. Peter; Waterman, Michael R.; Lepesheva, Galina I.

Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-11-19

OAAI

Friggeri, Laura; Hargrove, Tatiana Y.; Rachakonda, Girish; Blobaum, Anna L.; Fisher, Paxtyn; de Oliveira, Gabriel Melo; da Silva, Cristiane Franca; Soeiro, Maria de Nazare C.; Nes, W. David; Lindsley, Craig W.; Villalta, Fernando; Guengerich, F. Peter; Lepesheva, Galina I.

Sterol 14α-Demethylase Structure-Based Design of VNI ((R)-N-(1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-06-12

OAAI

Friggeri, Laura; Hargrove, Tatiana Y.; Wawrzak, Zdzislaw; Blobaum, Anna L.; Rachakonda, Girish; Lindsley, Craig W.; Villalta, Fernando; Nes, W. David; Botta, Maurizio; Guengerich, F. Peter; Lepesheva, Galina, I

Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2017-07-01

OAAI

Hargrove, Tatiana Y.; Garvey, Edward P.; Hoekstra, William J.; Yates, Christopher M.; Wawrzak, Zdzislaw; Rachakonda, Girish; Villalta, Fernando; Lepesheva, Galina I.

Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana

PLOS NEGLECTED TROPICAL DISEASES

IF3.4

2017-06-16

OAAI

Mwenechanya, Roy; Kovarova, Julie; Dickens, Nicholas J.; Mudaliar, Manikhandan; Herzyk, Pawel; Vincent, Isabel M.; Weidt, Stefan K.; Burgess, Karl E.; Burchmore, Richard J. S.; Pountain, Andrew W.; Smith, Terry K.; Creek, Darren J.; Kim, Dong-Hyun; Lepesheva, Galina I.; Barrett, Michael P.

Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2017-04-01

281

OAAI

Hargrove, Tatiana Y.; Friggeri, Laura; Wawrzak, Zdzislaw; Qi, Aidong; Hoekstra, William J.; Schotzinger, Robert J.; York, John D.; Guengerich, F. Peter; Lepesheva, Galina I.

研究方向