Identification of potent pan- ephrin receptor kinase inhibitors using DNA- encoded chemistry technologyPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAIF9.12024-05-033PRE
CYP3A Mediates an Unusual C(sp2)-C(sp3) Bond Cleavage via Ipso-Addition of Oxygen in Drug MetabolismANGEWANDTE CHEMIE-INTERNATIONAL EDITIONIF16.92024-04-290OA
Advancing ASMS with LC-MS/MS for the discovery of novel PDCL2 ligands from DNA-encoded chemical library selectionsANDROLOGYIF3.42022-11-023OAAI
A unified strategy for the total syntheses of eribulin and a macrolactam analogue of halichondrin BPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAIF9.12022-08-056OAAI
Metabolism of anti-inflammatory OXE (oxoeicosanoid) receptor antagonists by nonhuman primates#EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCESIF4.72022-05-011OA
Targeting the OXE receptor with a selective antagonist inhibits allergen-induced pulmonary inflammation in non-human primatesBRITISH JOURNAL OF PHARMACOLOGYIF7.72021-12-167OA
A Highly Convergent Total Synthesis of Norhalichondrin BJOURNAL OF THE AMERICAN CHEMICAL SOCIETYIF15.62021-12-016PREAI
A Reverse Approach to the Total Synthesis of Halichondrin BJOURNAL OF THE AMERICAN CHEMICAL SOCIETYIF15.62021-06-0918PREAI
Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody-Drug Conjugates, Insights into Structure-Activity Relationships, and Tubulysin-Tubulin Binding Derived from X-ray Crystallographic AnalysisJOURNAL OF ORGANIC CHEMISTRYIF3.62021-02-0511PREAI
Novel highly potent OXE receptor antagonists with prolonged plasma lifetimes that are converted to active metabolites in vivo in monkeysBRITISH JOURNAL OF PHARMACOLOGYIF7.72020-01-1711OAAI
Inhibition of allergen-induced dermal eosinophilia by an oxoeicosanoid receptor antagonist in non-human primatesBRITISH JOURNAL OF PHARMACOLOGYIF7.72020-01-179OAAI
In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys (vol 138, pg 107, 2018)BIOCHEMICAL PHARMACOLOGYIF5.62018-08-010PREAI
Novel Highly Potent and Metabolically Resistant Oxoeicosanoid (OXE) Receptor Antagonists That Block the Actions of the Granulocyte Chemoattractant 5-Oxo-6,8,11,14-Eicosatetraenoic Acid (5-oxo-ETE)JOURNAL OF MEDICINAL CHEMISTRYIF6.82018-07-048PREAI
Metabolism and pharmacokinetics of a potent N-acylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) in rats and monkeysEUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCESIF4.72018-03-018OAAI
In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeysBIOCHEMICAL PHARMACOLOGYIF5.62017-08-0111OAAI
Design and synthesis of affinity chromatography ligands for the purification of 5-hydroxyeicosanoid dehydrogenase亲和层析配体的设计与合成纯化5-羟基类生物碱脱氢酶BIOORGANIC & MEDICINAL CHEMISTRYIF32017-01-014OAAI
Pharmacokinetics and Metabolism of Selective Oxoeicosanoid (OXE) Receptor Antagonists and Their Effects on 5-Oxo-6,8,11,14-eicosatetraenoic Acid (5-Oxo-ETE)-Induced Granulocyte Activation in MonkeysJOURNAL OF MEDICINAL CHEMISTRYIF6.82016-11-0716PREAI
Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytesBIOCHEMICAL PHARMACOLOGYIF5.62015-08-0116OAAI
Two Potent OXE-R Antagonists: Assignment of StereochemistryACS MEDICINAL CHEMISTRY LETTERSIF42014-06-0314OAAI
Inhibition of 5-Oxo-6,8,11,14-eicosatetraenoic Acid-Induced Activation of Neutrophils and Eosinophils by Novel Indole OXE Receptor AntagonistsJOURNAL OF MEDICINAL CHEMISTRYIF6.82014-01-0630OAAI
个人简介
教育背景
工作经历
荣誉奖项
未登录.png){kind=icon}
未登录个人简介教育背景工作经历荣誉奖项
研究方向