Lars Olsen - Publications, H-index & Citations

Lars Olsen

University of Copenhagen

43H指数

161论文数

6.1K被引数

收录论文 69

发表时间

Both Reactivity and Accessibility Are Important in Cytochrome P450 Metabolism: A Combined DFT and MD Study of Fenamic Acids in BM3 Mutants

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2019-02-13

PREAI

Leth, Rasmus; Ercig, Bogac; Olsen, Lars; Jorgensen, Flemming Steen

The anti-epileptic drug lamotrigine inhibits the CYP17A1 lyase reaction in vitro

BIOLOGY OF REPRODUCTION

IF3

2018-04-26

OAAI

Munkboel, Cecilie Hurup; Christensen, Lise Rudbaek; Islin, Julie; Bonomo, Silvia; Olsen, Lars; Jorgensen, Flemming Steen; Styrishave, Bjarne

Potent Inhibitors against Newcastle Disease Virus Hemagglutinin-Neuraminidase 抗新城疫的有效抑制剂病毒血凝素-神经氨酸酶

CHEMMEDCHEM

IF3.4

2018-01-09

OAAI

Rota, Paola; La Rocca, Paolo; Piccoli, Marco; Montefiori, Marco; Cirillo, Federica; Olsen, Lars; Orioli, Marica; Allevi, Pietro; Anastasia, Luigi

Lysine demethylase inhibition protects pancreatic β cells from apoptosis and improves β-cell function

MOLECULAR AND CELLULAR ENDOCRINOLOGY

IF3.6

2018-01-01

PREAI

Backe, Marie Balslev; Andersson, Jan Legaard; Bacos, Karl; Christensen, Dan Ploug; Hansen, Jakob Bondo; Dorosz, Jerzy Jozef; Gajhede, Michael; Dahlby, Tina; Bysani, Madhusudhan; Kristensen, Line Hyltoft; Ling, Charlotte; Olsen, Lars; Mandrup-Poulsen, Thomas

7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-12-19

OAAI

Goffin, Eric; Drapier, Thomas; Larsen, Anja Probst; Geubelle, Pierre; Ptak, Christopher P.; Laulumaa, Saara; Rovinskaja, Karoline; Gilissen, Julie; de Tullio, Pascal; Olsen, Lars; Frydenvang, Karla; Pirotte, Bernard; Hanson, Julien; Oswald, Robert E.; Kastrup, Jette Sandholm; Francotte, Pierre

Aldehyde Oxidase: Reaction Mechanism and Prediction of Site of Metabolism

ACS OMEGA

IF4.3

2017-08-04

OAAI

Montefiori, Marco; Jorgensen, Flemming Steen; Olsen, Lars

Mechanism of Cytochrome P450 17A1-Catalyzed Hydroxylase and Lyase Reactions

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2017-04-19

PREAI

Bonomo, Silvia; Jorgensen, Flemming Steen; Olsen, Lars

The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region

SCIENTIFIC REPORTS

IF3.9

2017-04-07

OAAI

Tapken, Daniel; Steffensen, Thomas Bielefeldt; Leth, Rasmus; Kristensen, Lise Baadsgaard; Gerbola, Alexander; Gajhede, Michael; Jorgensen, Flemming Steen; Olsen, Lars; Kastrup, Jette Sandholm

The CYP79A1 catalyzed conversion of tyrosine to (E)-p-hydroxyphenylacetaldoxime unravelled using an improved method for homology modeling

PHYTOCHEMISTRY

IF3.4

2017-03-01

PREAI

Vazquez-Albacete, Dario; Montefiori, Marco; Kol, Stefan; Motawia, Mohammed Saddik; Moller, Birger Lindberg; Olsen, Lars; Norholm, Morten H. H.

Dissecting the Cytochrome P450 1A2-and 3A4-Mediated Metabolism of Aflatoxin B1 in Ligand and Protein Contributions

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2017-01-30

PREAI

Bonomo, Silvia; Jorgensen, Flemming Steen; Olsen, Lars

Structure-based optimisation of non-steroidal cytochrome P450 17A1 inhibitors

CHEMICAL COMMUNICATIONS

IF4.2

2017-01-01

PREAI

Larsen, Morten; Hansen, Cecilie H.; Rasmussen, Tobias B.; Islin, Julie; Styrishave, Bjarne; Olsen, Lars; Jorgensen, Flemming Steen

Deglaciation of Fennoscandia Fennoscandia的冰消作用

QUATERNARY SCIENCE REVIEWS

IF3.3

2016-09-01

460

OAAI

Stroeven, Arjen P.; Hattestrand, Clas; Kleman, Johan; Heyman, Jakob; Fabel, Derek; Fredin, Ola; Goodfellow, Bradley W.; Harbor, Jonathan M.; Jansen, John D.; Olsen, Lars; Caffee, Marc W.; Fink, David; Lundqvist, Jan; Rosqvist, Gunhild C.; Stromberg, Bo; Jansson, Krister N.

Promising Tools in Prostate Cancer Research: Selective Non-Steroidal Cytochrome P450 17A1 Inhibitors 前列腺癌研究的有希望的工具: 选择性非甾体细胞色素P450 17A1抑制剂

SCIENTIFIC REPORTS

IF3.9

2016-07-12

OAAI

Bonomo, Silvia; Hansen, Cecilie H.; Petrunak, Elyse M.; Scott, Emily E.; Styrishave, Bjarne; Jorgensen, Flemming Steen; Olsen, Lars

Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2

BIOPHYSICAL JOURNAL

IF3.1

2016-06-01

OAAI

Krintel, Christian; Francotte, Pierre; Pickering, Darryl S.; Juknaite, Lina; Pohlsgaard, Jacob; Olsen, Lars; Frydenvang, Karla; Goffin, Eric; Pirotte, Bernard; Kastrup, Jette S.

Insights into regioselective metabolism of mefenamic acid by Cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

IF2.8

2016-02-03

PREAI

Capoferri, Luigi; Leth, Rasmus; ter Haar, Ernst; Mohanty, Arun K.; Grootenhuis, Peter D. J.; Vottero, Eduardo; Commandeur, Jan N. M.; Vermeulen, Nico P. E.; Jorgensen, Flemming Steen; Olsen, Lars; Geerke, Daan P.

Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors

MOLECULAR PHARMACOLOGY

IF3

2016-02-01

OAAI

Kristensen, Anders S.; Hansen, Kasper B.; Naur, Peter; Olsen, Lars; Kurtkaya, Natalie L.; Dravid, Shashank M.; Kvist, Trine; Yi, Feng; Pohlsgaard, Jacob; Clausen, Rasmus P.; Gajhede, Michael; Kastrup, Jette S.; Traynelis, Stephen F.

Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2015-12-22

PREAI

Szymanska, Ewa; Frydenvang, Karla; Pickering, Darryl S.; Krintel, Christian; Nielsen, Birgitte; Kooshki, Ayesheh; Zachariassen, Linda G.; Olsen, Lars; Kastrup, Jette S.; Johansen, Tommy N.

Salt Bridge Swapping in the EXXERFXYY Motif of Proton-coupled Oligopeptide Transporters

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2015-12-01

OAAI

Aduri, Nanda G.; Prabhala, Bala K.; Ernst, Heidi A.; Jorgensen, Flemming S.; Olsen, Lars; Mirza, Osman

Prediction of cytochrome P450 mediated metabolism

ADVANCED DRUG DELIVERY REVIEWS

IF17.6

2015-06-01

PREAI

Olsen, Lars; Oostenbrink, Chris; Jorgensen, Flemming Steen