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G

Gisele Nishiguchi

st jude childrens research hospital
H指数:19
被引数:1,987

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Direct-to-Biology Enabled Molecular Glue Discovery
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
2025-12-010
PRE
Hu, Maowei; Ochoada, Jason; Actis, Marisa; McGowan, Kevin; Jarusiewicz, Jamie A.; Yoshimura, Satoshi; McGrath, Logan; Neelakantan, Uma; Aggarwal, Anup; Mayasundari, Anand; Young, Sarah M.; Zhang, Meng; Yang, Lei; Li, Yong; Mercer, Shea; Babu, M. Madan; Fischer, Marcus; Young, Brandon M.; Yang, Jun J.; Nishiguchi, Gisele; Shelat, Anang A.; Blair, Daniel J.
Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics

利用高通量蛋白质组学对cereblon新底物景观的无偏映射

Nature Communications
IF15.7
2025-08-200
OAAI
Martin Steger; Gisele Nishiguchi; Qiong Wu; Bjoern Schwalb; Bachuki Shashikadze; Kevin McGowan; Marisa Actis; Anup Aggarwal; Zhe Shi; Jeanine Price; Anand Mayasundari; Lei Yang; Anastasia H. Bednarz; Sophie Machata; Tobias Graef; Denis Bartoschek; Vadim Demichev; Uli Ohmayer; Jun Yang; Henrik Daub; Zoran Rankovic
Structure-Activity Relationship of Potent, Selective, and Orally Bioavailable Molecular Glue Degraders of CK1α

CK1α 的有效，选择性和口服生物利用度分子胶降解剂的构效关系

ACS MEDICINAL CHEMISTRY LETTERS
IF4
2024-09-121
PRE
Nishiguchi, Gisele; Caine, Elizabeth A.; Mcgowan, Kevin; Shi, Zhe; Aggarwal, Anup; Mayasundari, Anand; Price, Jeanine; Yang, Lei; Li, Yong; Fu, Xiang; Mascibroda, Lauren G.; Das, Sourav; Daniels, Danette L.; Urh, Marjeta; Klco, Jeffery M.; Riching, Kristin M.; Rankovic, Zoran
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines
NATURE COMMUNICATIONS
IF15.7
2024-01-169
OAAI
Nishiguchi, Gisele; Mascibroda, Lauren G.; Young, Sarah M.; Caine, Elizabeth A.; Abdelhamed, Sherif; Kooijman, Jeffrey J.; Miller, Darcie J.; Das, Sourav; McGowan, Kevin; Mayasundari, Anand; Shi, Zhe; Barajas, Juan M.; Hiltenbrand, Ryan; Aggarwal, Anup; Chang, Yunchao; Mishra, Vibhor; Narina, Shilpa; Thomas, Melvin; Loughran, Allister J.; Kalathur, Ravi; Yu, Kaiwen; Zhou, Suiping; Wang, Xusheng; High, Anthony A.; Peng, Junmin; Pruett-Miller, Shondra M.; Daniels, Danette L.; Urh, Marjeta; Shelat, Anang A.; Mullighan, Charles G.; Riching, Kristin M.; Zaman, Guido J. R.; Fischer, Marcus; Klco, Jeffery M.; Rankovic, Zoran
Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs

苯基戊二酰亚胺: 用于PROTACs设计的替代cerebon粘合剂

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
2021-11-1678
OA
Min, Jaeki; Mayasundari, Anand; Keramatnia, Fatemeh; Jonchere, Barbara; Yang, Seung Wook; Jarusiewicz, Jamie; Actis, Marisa; Das, Sourav; Young, Brandon; Slavish, Jake; Yang, Lei; Li, Yong; Fu, Xiang; Garrett, Shalandus H.; Yun, Mi-Kyung; Li, Zhenmei; Nithianantham, Stanley; Chai, Sergio; Chen, Taosheng; Shelat, Anang; Lee, Richard E.; Nishiguchi, Gisele; White, Stephen W.; Roussel, Martine F.; Potts, Patrick Ryan; Fischer, Marcus; Rankovic, Zoran
Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-05-2763
OAAI
Nishiguchi, Gisele; Keramatnia, Fatemeh; Min, Jaeki; Chang, Yunchao; Jonchere, Barbara; Das, Sourav; Actis, Marisa; Price, Jeanine; Chepyala, Divyabharathi; Young, Brandon; McGowan, Kevin; Slavish, P. Jake; Mayasundari, Anand; Jarusiewicz, Jamie A.; Yang, Lei; Li, Yong; Fu, Xiang; Garrett, Shalandus H.; Papizan, James B.; Kodali, Kiran; Peng, Junmin; Miller, Shondra M. Pruett; Roussel, Martine F.; Mullighan, Charles; Fischer, Marcus; Rankovic, Zoran
Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-05-0632
OAAI
Ramurthy, Savithri; Taft, Benjamin R.; Aversa, Robert J.; Barsanti, Paul A.; Burger, Matthew T.; Lou, Yan; Nishiguchi, Gisele A.; Rico, Alice; Setti, Lina; Smith, Aaron; Subramanian, Sharadha; Tamez, Victoriano; Tanner, Huw; Wan, Lifeng; Hu, Cheng; Appleton, Brent A.; Mamo, Mulugeta; Tandeske, Laura; Tellew, John E.; Huang, Shenlin; Yue, Qn; Cliaudliary, Apurva; Tian, Hung; Iyer, Raman; Hassan, A. Quamrul; Griner, Lesley A. Mathews; La Bonte, Laura R.; Cooke, Vesselina G.; Van Abbema, Anne; Merritt, Hanne; Gampa, Kalyani; Feng, Fei; Yuan, Jing; Mishina, Yuji; Wang, Yingyun; Haling, Jacob R.; Vaziri, Sepideh; Hekmat-Nejad, Mohammad; Polyakov, Valery; Zang, Richard; Sethuraman, Vijay; Amiri, Payman; Singh, Mallika; Sellers, William R.; Lees, Emma; Shao, Wenlin; Dillon, Michael P.; Stuart, Darrin D.
Simultaneous inhibition of SHP2 phosphatase at two allosteric sites
CANCER RESEARCH
IF16.6
2018-07-011
PRE
Fodor, Michelle; Price, Edmund; Wang, Ping; Lu, Hengyu; Argintaru, Andreea; Chen, Zhouliang; Glick, Meir; Hao, Huai-Xiang; Kato, Mitsunori; Koenig, Robert; LaRochelle, Jonathan R.; Liu, Gang; McNeill, Eric; Majumdar, Dyuti; Nishiguchi, Gisele; Perez, Lawrence; Paris, Greg; Quinn, Christopher; Ramsey, Timothy; Sendzik, Martin; Shultz, Michael; Williams, Sarah; Stams, Travis; Blacklow, Stephen C.; LaMarche, Matthew J.; Acker, Michael G.
Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF
CANCER RESEARCH
IF16.6
2018-03-1430
OAAI
Shao, Wenlin; Mishina, Yuji M.; Feng, Yun; Caponigro, Giordano; Cooke, Vesselina G.; Rivera, Stacy; Wang, Yingyun; Shen, Fang; Korn, Joshua M.; Griner, Lesley A. Mathews; Nishiguchi, Gisele; Rico, Alice; Tellew, John; Haling, Jacob R.; Aversa, Robert; Polyakov, Valery; Zang, Richard; Hekmat-Nejad, Mohammad; Amiri, Payman; Singh, Mallika; Keen, Nicholas; Dillon, Michael P.; Lees, Emma; Ramurthy, Savithri; Sellers, William R.; Stuart, Darrin D.
Dual Allosteric Inhibition of SHP2 Phosphatase
ACS CHEMICAL BIOLOGY
IF3.8
2018-01-05110
OAAI
Fodor, Michelle; Price, Edmund; Wang, Ping; Lu, Hengyu; Argintaru, Andreea; Chen, Zhouliang; Glick, Meir; Hao, Huai-Xiang; Kato, Mitsunori; Koenig, Robert; LaRochelle, Jonathan R.; Liu, Gang; McNeill, Eric; Majumdar, Dyuti; Nishiguchi, Gisele A.; Perez, Lawrence B.; Paris, Gregory; Quinn, Christopher M.; Ramsey, Timothy; Sendzik, Martin; Shultz, Michael David; Williams, Sarah L.; Stams, Travis; Blacklow, Stephen C.; Acker, Michael G.; LaMarche, Matthew J.
Design and Discovery of N-(2-Methyl-5′-morpholino-6′-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2017-06-0846
PREAI
Nishiguchi, Gisele A.; Rico, Alice; Tanner, Huw; Aversa, Robert J.; Taft, Benjamin R.; Subramanian, Sharadha; Setti, Lina; Burger, Matthew T.; Wan, Lifeng; Tamez, Victoriano; Smith, Aaron; Lou, Yan; Barsanti, Paul A.; Appleton, Brent A.; Mamo, Mulugeta; Tandeske, Laura; Dix, Ina; Tellew, John E.; Huang, Shenlin; Griner, Lesley A. Mathews; Cooke, Vesselina G.; Van Abbema, Anne; Merritt, Hanne; Ma, Sylvia; Gampa, Kalyani; Feng, Fei; Yuan, Jing; Wang, Yingyun; Haling, Jacob R.; Vaziri, Sepideh; Hekmat-Nejad, Mohammad; Jansen, Johanna M.; Polyakov, Valery; Zang, Richard; Sethuraman, Vijay; Amiri, Payman; Singh, Mallika; Lees, Emma; Shao, Wenlin; Stuart, Darrin D.; Dillon, Michael P.; Ramurthy, Savithri
Development of a highly selective B/CRAF kinase inhibitor that exhibits antitumor activities in RAS and BRAF mutant tumors with minimal paradoxical activation
CANCER RESEARCH
IF16.6
2016-07-150
PRE
Shao, Wenlin; Mishina, Yuji; Feng, Yun; Caponigro, Giordano; Ramurthy, Savithri; Cooke, Vesselina; Griner, Lesley; Nishiguchi, Gisele; Rico, Alice; Taft, Ben; Burger, Matthew; Tanner, Huw; Polyakov, Valery; Appleton, Brent; Tellew, John; Zang, Richard; Hekmat-Nejad, Mohammad; Amiri, Payman; Singh, Mallika; Stuart, Darrin

研究方向

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Z
Zoran Ranković
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A
Anand Mayasundari
H 指数:19论文数:74被引数:1,554
J
Jamie Jarusiewicz
H 指数:11论文数:28被引数:707
L
Lei Yang
H 指数:32论文数:113被引数:2,941
M
Marisa Actis
H 指数:10论文数:33被引数:559
M
Marcus Fischer
H 指数:33论文数:161被引数:4,708
M
Matthew T. Burger
H 指数:18论文数:49被引数:1,650
R
Richard Zang
H 指数:17论文数:78被引数:1,667
S
Sourav Das
H 指数:16论文数:60被引数:1,131
Y
Yong Li
H 指数:27论文数:115被引数:4,536