Raphael Bigler

f. hoffmann-la roche ag

16H指数

65论文数

884被引数

收录论文 12

发表时间

Swarm intelligence for chemical reaction optimization 群智能用于化学反应优化

Chem

IF19.6

2026-04-17

OAAI

Rémi Schlama; Joshua W. Sin; Ryan P. Burwood; Kurt Püntener; Raphael Bigler; Philippe Schwaller

Single-position ligand modifications tune CB2R activity by targeting the toggle switch 单一位点的配体修饰通过靶向开关来调节CB2R活性。

chem. sci.

IF0

2026-03-25

OAAI

Rudolf L. Z. Ganzoni †; Miroslav Kosar †; Yongqi Han; Rosa Maria Vitale; Pietro Amodeo; Xiaoting Li; Zhonghua Zha; Kacper J. Patej; Bilal Kicin; Taddäus E. N. Strunden; Lisa Reichert; Uxía Gómez-Bouzó; Themiya P. Perera; Kenneth Atz; Wolfgang Guba; Christian Bartelmus; Raphael Bigler; Paolo Tosatti; Stephan Bachmann; Tian Hua; David A. Sykes; Dmitry B. Veprintsev; Uwe Grether; Erick M. Carreira

Highly parallel optimisation of chemical reactions through automation and machine intelligence 通过自动化和机器智能实现化学反应的高度并行优化

Nature Communications

IF15.7

2025-07-12

OAAI

Joshua W. Sin; Siu Lun Chau; Ryan P. Burwood; Kurt Püntener; Raphael Bigler; Philippe Schwaller

Fit-for-Purpose Synthesis of a KRASG12C Covalent Inhibitor, via a Diastereoselective Hayashi Arylation 通过非对映选择性Hayashi芳基化合成KRASG12C共价抑制剂

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2024-07-22

PREAI

Molinaro, Carmela; Wong, Nicholas; White, Nicholas A.; Sirois, Lauren E.; Bigler, Raphael; Bindschaedler, Quentin P.; Do, Steven; Malhotra, Sushant; Gosselin, Francis

Second-Generation Atroposelective Synthesis of KRAS G12C Covalent Inhibitor GDC-6036 第二代KRAS G12C共价抑制剂GDC-6036的选择性合成

ORGANIC LETTERS

IF5

2023-05-10

PREAI

Xu, Jie; Lim, Ngiap-Kie; Timmerman, Jacob C.; Shen, Jeff; Clagg, Kyle; Orcel, Ugo; Bigler, Raphael; Trachsel, Etienne; Meier, Roland; White, Nicholas A.; Burkhard, Johannes A.; Sirois, Lauren E.; Tian, Qingping; Angelaud, Remy; Bachmann, Stephan; Zhang, Haiming; Gosselin, Francis

Asymmetric Hydrogenation of Unfunctionalized Tetrasubstituted Acyclic Olefins 非官能化四取代无环烯烃的不对称氢化

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2020-01-21

OAAI

Bigler, Raphael; Mack, Kyle A.; Shen, Jeff; Tosatti, Paolo; Han, Chong; Bachmann, Stephan; Zhang, Haiming; Scalone, Michelangelo; Pfaltz, Andreas; Denmark, Scott E.; Hildbrand, Stefan; Gosselin, Francis

Enantiospecific Synthesis of ortho-Substituted 1,1-Diarylalkanes by a 1,2-Metalate Rearrangement/anti-SN2′ Elimination/Rearomatizing Allylic Suzuki-Miyaura Reaction Sequence 通过1，2-金属化物重排/anti-SN2 '消除/重排烯丙基suzuki-miyaura反应序列对邻位取代的1，1-二芳基烷烃的对映体特异性合成

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2018-12-21

OAAI

Rubial, Belen; Collins, Beatrice S. L.; Bigler, Raphael; Aichhorn, Stefan; Noble, Adam; Aggarwal, Varinder K.

ortho-Directing Chromium Arene Complexes as Efficient Mediators for Enantiospecific C(sp2)-C(sp3) Cross-Coupling Reactions

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2018-01-03

OAAI

Bigler, Raphael; Aggarwal, Varinder K.