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P

P. G. Humphreys

University of Oxford
H指数:21
被引数:1,701

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Chemist-aligned retrosynthesis by ensembling diverse inductive bias models

通过集成多样化的归纳偏置模型实现化学家对齐的逆向合成

Nature
IF48.5
2026-09-210
PRE
Krzysztof Maziarz; Guoqing Liu; Felix Pultar; John Gardner; Tobias Gensch; Jean Helie; Hubert Misztela; Austin Tripp; Junren Li; Aleksei Kornev; Piotr Gaiński; Holger Hoefling; Mike Fortunato; Rishi Gupta; Andrew Baxter; Darren L. Poole; Jennifer M. Elward; Adrian Krzyzanowski; Peter Pogány; Stephen D. Pickett; Ian D. Wall; Christopher M. Bishop; Philip G. Humphreys; James A. Lumley; Mario P. Wiesenfeldt; Marwin H. S. Segler
Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-06-120
PRE
Hirst, David J.; Bamborough, Paul; Al-Mahdi, Niam; Angell, Davina C.; Barnett, Heather A.; Baxter, Andrew; Bit, Rino A.; Brown, Jack A.; Chung, Chun-wa; Craggs, Peter D.; Davis, Robert P.; Demont, Emmanuel H.; Ferrie, Alan; Gordon, Laurie J.; Harada, Isobel; Ho, Tim C. T.; Holyer, Ian D.; Hooper-Greenhill, Edward; Jones, Katherine L.; Lindon, Matthew J.; Lovatt, Cerys; Lugo, David; Maller, Claire; Mcgonagle, Grant; Messenger, Cassie; Mitchell, Darren J.; Pascoe, David D.; Patel, Vipulkumar K.; Patten, Christopher; Poole, Darren L.; Shah, Rishi R.; Rioja, Inmaculada; Stafford, Kayleigh A. J.; Tape, Daniel; Taylor, Simon; Theodoulou, Natalie H.; Tomlinson, Laura; Wall, Ian D.; Wellaway, Christopher R.; White, Gemma; Prinjha, Rab K.; Humphreys, Philip G.
Identification and Optimization of a Ligand-Efficient Benzoazepinone Bromodomain and Extra Terminal (BET) Family Acetyl-Lysine Mimetic into the Oral Candidate Quality Molecule I-BET432
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-11-158
OA
Humphreys, Philip G.; Anderson, Niall A.; Bamborough, Paul; Baxter, Andrew; Chung, Chun-wa; Cookson, Rosa; Craggs, Peter D.; Dalton, Toryn; Fournier, Julie C. L.; Gordon, Laurie J.; Gray, Heather F.; Gray, Matthew W.; Gregory, Richard; Hirst, David J.; Jamieson, Craig; Jones, Katherine L.; Kessedjian, Hripsimee; Lugo, David; McGonagle, Grant; Patel, Vipulkumar K.; Patten, Christopher; Poole, Darren L.; Prinjha, Rab K.; Ramirez-Molina, Cesar; Rioja, Inmaculada; Seal, Gail; Stafford, Kayleigh A. J.; Shah, Rishi R.; Tape, Daniel; Theodoulou, Natalie H.; Tomlinson, Laura; Ukuser, Sabri; Wall, Ian D.; Wellaway, Natalie; White, Gemma
Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-01-0719
OA
Humphreys, Philip G.; Atkinson, Stephen J.; Bamborough, Paul; Bit, Rino A.; Chung, Chun-Wa; Craggs, Peter D.; Cutler, Leanne; Davis, Rob; Ferrie, Alan; Gong, GangLi; Gordon, Laurie J.; Gray, Matthew; Harrison, Lee A.; Hayhow, Thomas G.; Haynes, Andrea; Henley, Nick; Hirst, David J.; Holyer, Ian D.; Lindon, Matthew J.; Lovatt, Cerys; Lugo, David; McCleary, Scott; Molnar, Judit; Osmani, Qendresa; Patten, Chris; Preston, Alex; Rioja, Inmaculada; Seal, Jonathan T.; Smithers, Nicholas; Sun, Fenglai; Tang, Dalin; Taylor, Simon; Theodoulou, Natalie H.; Thomas, Clare; Watson, Robert J.; Wellaway, Christopher R.; Zhu, Linrong; Tomkinson, Nicholas C. O.; Prinjha, Rab K.
Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-05-1530
OAAI
Clegg, Michael A.; Bamborough, Paul; Chung, Chun-wa; Craggs, Peter D.; Gordon, Laurie; Grandi, Paola; Leveridge, Melanie; Lindon, Matthew; Liwicki, Gemma M.; Michon, Anne-Marie; Molnar, Judit; Rioja, Inmaculada; Soden, Peter E.; Theodoulou, Natalie H.; Werner, Thilo; Tomkinson, Nicholas C. O.; Prinjha, Rab K.; Humphreys, Philip G.
Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-01-0648
PREAI
Wellaway, Christopher R.; Amans, Dominique; Bamborough, Paul; Barnett, Heather; Bit, Rino A.; Brown, Jack A.; Carlson, Neil R.; Chung, Chun-wa; Cooper, Anthony W. J.; Craggs, Peter D.; Davis, Robert P.; Dean, Tony W.; Evans, John P.; Gordon, Laurie; Harada, Isobel L.; Hirst, David J.; Humphreys, Philip G.; Jones, Katherine L.; Lewis, Antonia J.; Lindon, Matthew J.; Lugo, Dave; Mahmood, Mahnoor; McCleary, Scott; Medeiros, Patricia; Mitchell, Darren J.; O'Sullivan, Michael; Le Gall, Armelle; Patel, Vipulkumar K.; Patten, Chris; Poole, Darren L.; Shah, Rishi R.; Smith, Jane E.; Stafford, Kayleigh A. J.; Thomas, Pamela J.; Vimal, Mythily; Wall, Ian D.; Watson, Robert J.; Wellaway, Natalie; Yao, Gang; Prinjha, Rab K.
Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach

通过PROTAC方法调节PCAF/GCN5免疫细胞功能

ACS CHEMICAL BIOLOGY
IF3.8
2018-09-10134
PREAI
Bassi, Zuni I.; Fillmore, Martin C.; Miah, Afjal H.; Chapman, Trevor D.; Maller, Claire; Roberts, Emma J.; Davis, Lauren C.; Lewis, Darcy E.; Galwey, Nicholas W.; Waddington, Kirsty E.; Parravicini, Valentino; Macmillan-Jones, Abigail L.; Gongora, Celine; Humphreys, Philip G.; Churcher, Ian; Prinjha, Rab K.; Tough, David F.
BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability
BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2018-07-0122
OAAI
Jennings, Laura E.; Schiedel, Matthias; Hewings, David S.; Picaud, Sarah; Laurin, Corentine M. C.; Bruno, Paul A.; Bluck, Joseph P.; Scorah, Amy R.; See, Larissa; Reynolds, Jessica K.; Moroglu, Mustafa; Mistry, Ishna N.; Hicks, Amy; Guzanov, Pavel; Clayton, James; Evans, Charles N. G.; Stazi, Giulia; Biggin, Philip C.; Mapp, Anna K.; Hammond, Ester M.; Humphreys, Philip G.; Filippakopoulos, Panagis; Conway, Stuart J.
Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2016-01-1564
PREAI
Westaway, Susan M.; Preston, Alex G. S.; Barker, Michael D.; Brown, Fiona; Brown, Jack A.; Campbell, Matthew; Chung, Chun-wa; Drewes, Gerard; Eagle, Robert; Garton, Neil; Gordon, Laurie; Haslam, Carl; Hayhow, Thomas G.; Humphreys, Philip G.; Joberty, Gerard; Katso, Roy; Kruidenier, Laurens; Leveridge, Melanie; Pemberton, Michelle; Rioja, Inma; Seal, Gail A.; Shipley, Tracy; Singh, Onkar; Suckling, Colin J.; Taylor, Joanna; Thomas, Pamela; Wilson, David M.; Lee, Kevin; Prinjha, Rab K.
Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2016-01-1549
PREAI
Westaway, Susan M.; Preston, Alex G. S.; Barker, Michael D.; Brown, Fiona; Brown, Jack A.; Campbell, Matthew; Chung, Chun-wa; Diallo, Hawa; Douault, Clement; Drewes, Gerard; Eagle, Robert; Gordon, Laurie; Haslam, Carl; Hayhow, Thomas G.; Humphreys, Philip G.; Joberty, Gerard; Katso, Roy; Kruidenier, Laurens; Leveridge, Melanie; Liddle, John; Mosley, Julie; Muelbaier, Marcel; Randle, Rebecca; Rioja, Inma; Rueger, Anne; Seal, Gail A.; Sheppard, Robert J.; Singh, Onkar; Taylor, Joanna; Thomas, Pamela; Thomson, Douglas; Wilson, David M.; Lee, Kevin; Prinjha, Rab K.

研究方向

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R
Rab K. Prinjha
H 指数:64论文数:229被引数:1.9万
C
Chun‐wa Chung
H 指数:48论文数:141被引数:1.2万
N
Nicholas C. O. Tomkinson
H 指数:39论文数:295被引数:5,120
L
Laurie Gordon
H 指数:28论文数:81被引数:2,367
N
Natalie H. Theodoulou
H 指数:9论文数:24被引数:518
P
Paul Bamborough
H 指数:41论文数:121被引数:6,011
P
Peter D. Craggs
H 指数:18论文数:48被引数:1,988
M
Matthew Lindon
H 指数:17论文数:23被引数:1,627
I
Inmaculada Rioja
H 指数:27论文数:63被引数:2,288
J
Jack A. Brown
H 指数:17论文数:72被引数:1,164