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R

Rab K. Prinjha

GlaxoSmithKline
H指数:64
被引数:1.9万

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荣誉奖项

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Differential BET protein recruitment to IL6 and IL8 promoters and suppression of inflammatory and cell cycle genes by BET inhibitor in keratinocytes

角化细胞中BET蛋白对IL6和IL8启动子的差异性募集以及BET抑制剂对炎症和细胞周期基因的抑制作用

Journal of Investigative Dermatology
IF5.7
2026-09-130
PRE
Keith C.P. Wu; Nicola R. Harker; Simon J. Cockell; John Casement; Michael J. Donaldson; Erika Cule; Paul A. Wilson; Rab K. Prinjha; Mary A. Morse; Nick J. Reynolds
SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry
Nature Genetics
IF29
2026-07-210
PRE
Brian J. Liddicoat; Jesse J. Balic; Wendy Jia; Andrea Gillespie; Andrew B. Das; Laura Scolamiero; Naiara G. Bediaga; Yih-Chih Chan; Christa van der Maarel; Andrew A. Guirguis; Kelsy Prest; Oliver J. Sinclair; Laure Talarmain; Cassandra Litchfield; Enid Y. N. Lam; Sebastian Hollizeck; John R. Horton; Benjamin Kroeger; Tao Wang; Francesca Zappacosta; Roland S. Annan; Rab K. Prinjha; Melissa B. Pappalardi; Michael T. McCabe; Ching-Seng Ang; Matthew S. Graus; Mathias Francois; Kieran F. Harvey; Sarah-Jane Dawson; Xiaodong Cheng; Mark A. Dawson
NLRP3 inflammasome–driven hemophagocytic lymphohistiocytosis occurs independent of IL-1β and IL-18 and is targetable by BET inhibitors

NLRP3炎性小体驱动的噬血细胞性淋巴组织细胞增多症的发生与IL-1β和IL-18无关，且可被BET抑制剂靶向治疗。

Science Advances
IF12.5
2025-07-090
PREAI
Farzaneh Shojaee; Esmaeel Azadian; Min Xian Wong; Xiuquan Ma; James Rickard; Jiyi Pang; Catherine Hall; Andrew J. Kueh; Seth L. Masters; Inmaculada Rioja; Rab K. Prinjha; Marcel Doerflinger; Kate E. Lawlor; Maryam Rashidi; James E. Vince
Acute Resistance to BET Inhibitors Remodels Compensatory Transcriptional Programs Via p300 Co-Activation

急性对BET抑制剂的耐药性通过p300协同激活重塑补偿性转录程序

BLOOD
IF23.1
2024-11-050
PRE
Shah, Viral; Giotopoulos, George; Osaki, Hikari; Meyerhoefer, Markus; Meduri, Eshwar; Gallego-Crespo, Aaron; Behrendt, Malte Andreas; Saura-Panella, Maria; Schubert, Benedict; Yun, Haiyang; Horton, Sarah J.; Singh, Shuchi Agrawal; Haehnel, Patricia S.; Basheer, Faisal; Lugo, Dave; Kuehn, Michael; Guezguez, Borhane; Theobald, Matthias; Kindler, Thomas; Gallipoli, Paolo; Yeh, Paul; Dawson, Mark A.; Prinjha, Rab; Huntly, Brian J. P.; Sasca, Daniel
Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-06-120
PRE
Hirst, David J.; Bamborough, Paul; Al-Mahdi, Niam; Angell, Davina C.; Barnett, Heather A.; Baxter, Andrew; Bit, Rino A.; Brown, Jack A.; Chung, Chun-wa; Craggs, Peter D.; Davis, Robert P.; Demont, Emmanuel H.; Ferrie, Alan; Gordon, Laurie J.; Harada, Isobel; Ho, Tim C. T.; Holyer, Ian D.; Hooper-Greenhill, Edward; Jones, Katherine L.; Lindon, Matthew J.; Lovatt, Cerys; Lugo, David; Maller, Claire; Mcgonagle, Grant; Messenger, Cassie; Mitchell, Darren J.; Pascoe, David D.; Patel, Vipulkumar K.; Patten, Christopher; Poole, Darren L.; Shah, Rishi R.; Rioja, Inmaculada; Stafford, Kayleigh A. J.; Tape, Daniel; Taylor, Simon; Theodoulou, Natalie H.; Tomlinson, Laura; Wall, Ian D.; Wellaway, Christopher R.; White, Gemma; Prinjha, Rab K.; Humphreys, Philip G.
Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells
CLINICAL EPIGENETICS
IF4.4
2023-04-152
OAAI
Quintela, Marcos; James, David W.; Pociute, Agne; Powell, Lydia; Edwards, Kadie; Coombes, Zoe; Garcia, Jetzabel; Garton, Neil; Das, Nagindra; Lutchman-Singh, Kerryn; Margarit, Lavinia; Beynon, Amy L.; Rioja, Inmaculada; Prinjha, Rab K.; Harker, Nicola R.; Gonzalez, Deyarina; Conlan, R. Steven; Francis, Lewis W.
Identification and Optimization of a Ligand-Efficient Benzoazepinone Bromodomain and Extra Terminal (BET) Family Acetyl-Lysine Mimetic into the Oral Candidate Quality Molecule I-BET432
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-11-158
OA
Humphreys, Philip G.; Anderson, Niall A.; Bamborough, Paul; Baxter, Andrew; Chung, Chun-wa; Cookson, Rosa; Craggs, Peter D.; Dalton, Toryn; Fournier, Julie C. L.; Gordon, Laurie J.; Gray, Heather F.; Gray, Matthew W.; Gregory, Richard; Hirst, David J.; Jamieson, Craig; Jones, Katherine L.; Kessedjian, Hripsimee; Lugo, David; McGonagle, Grant; Patel, Vipulkumar K.; Patten, Christopher; Poole, Darren L.; Prinjha, Rab K.; Ramirez-Molina, Cesar; Rioja, Inmaculada; Seal, Gail; Stafford, Kayleigh A. J.; Shah, Rishi R.; Tape, Daniel; Theodoulou, Natalie H.; Tomlinson, Laura; Ukuser, Sabri; Wall, Ian D.; Wellaway, Natalie; White, Gemma
A BET Protein Inhibitor Targeting Mononuclear Myeloid Cells Affects Specific Inflammatory Mediators and Pathways in Crohn's Disease
CELLS
IF5.2
2022-09-123
OAAI
Elfiky, Ahmed M., I; Hageman, Ishtu L.; Becker, Marte A. J.; Verhoeff, Jan; Li Yim, Andrew Y. F.; Joustra, Vincent W.; Mulders, Lieven; Fung, Ivan; Rioja, Inmaculada; Prinjha, Rab K.; Smithers, Nicholas N.; Furze, Rebecca C.; Mander, Palwinder K.; Bell, Matthew J.; Buskens, Christianne J.; D'Haens, Geert R.; Wildenberg, Manon E.; de Jonge, Wouter J.

研究方向

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C
Chun‐wa Chung
H 指数:48论文数:141被引数:1.2万
I
Inmaculada Rioja
H 指数:27论文数:63被引数:2,285
P
Paul Bamborough
H 指数:41论文数:121被引数:6,007
E
Emmanuel H. Demont
H 指数:29论文数:107被引数:2,820
P
Paola Grandi
H 指数:40论文数:139被引数:1.5万
L
Laurie Gordon
H 指数:28论文数:81被引数:2,365
R
Robert J. Watson
H 指数:46论文数:208被引数:6,528
D
Darren J. Mitchell
H 指数:22论文数:58被引数:1,126
P
P. G. Humphreys
H 指数:21论文数:138被引数:1,699
S
S. Taylor
H 指数:54论文数:308被引数:1.0万