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S

Sharon Tentarelli

AstraZeneca
H指数:12
被引数:1,089

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Discovery of (2R,4R)-4-((S)-2-Amino-3-methylbutanamido)-2-(4-boronobutyl)pyrrolidine-2-carboxylic Acid (AZD0011), an Actively Transported Prodrug of a Potent Arginase Inhibitor to Treat Cancer
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-11-210
PRE
Mlynarski, Scott N.; Aquila, Brian M.; Cantin, Susan; Cook, Steve; Doshi, Aatman; Finlay, M. Raymond V.; Gangl, Eric T.; Grebe, Tyler; Gu, Chungang; Kawatkar, Sameer P.; Petersen, Jens; Pop-Damkov, Petar; Schuller, Alwin G.; Shao, Wenlin; Shields, Jason D.; Simpson, Iain; Tavakoli, Siavash; Tentarelli, Sharon; Throner, Scott; Wang, Haixia; Wang, Jianyan; Wu, Dedong; Ye, Qing
Optimization of Potent, Efficacious, Selective and Blood-Brain Barrier Penetrating Inhibitors Targeting EGFR Exon20 Insertion Mutations
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-09-280
PRE
Thomson, Clare; Braybrooke, Erin; Colclough, Nicola; Davies, Nichola L.; Floc'h, Nicolas; Greenwood, Ryan; Guerot, Carine; Hargreaves, David; Johnstrom, Peter; Khurana, Puneet; Kostomiris, Demetrios H.; Li, Songlei; Lister, Andrew; Lorthioir, Olivier; Martin, Scott; Mccoull, William; Mclean, Neville J.; Mcwilliams, Lisa; Orme, Jonathan P.; Packer, Martin J.; Pearson, Stuart; Swaih, Aisha M.; Tentarelli, Sharon; Tucker, Michael J.; Ward, Richard A.; Wilkinson, Stephen; Winlow, Poppy; Wood, Isabel L.
Development of a Series of Pyrrolopyridone MAT2A Inhibitors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-03-113
PRE
Atkinson, Stephen J.; Bagal, Sharan K.; Argyrou, Argyrides; Askin, Sean; Cheung, Tony; Chiarparin, Elisabetta; Coen, Muireann; Collie, Iain T.; Dale, Ian L.; De Fusco, Claudia; Dillman, Keith; Evans, Laura; Feron, Lyman J.; Foster, Alison J.; Grondine, Michael; Kantae, Vasudev; Lamont, Gillian M.; Lamont, Scott; Lynch, James T.; Lill, Sten Nilsson; Robb, Graeme R.; Saeh, Jamal; Schimpl, Marianne; Scott, James S.; Smith, James; Srinivasan, Bharath; Tentarelli, Sharon; Vazquez-Chantada, Mercedes; Wagner, David; Walsh, Jarrod J.; Watson, David; Williamson, Beth
Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners
MOLECULAR CANCER THERAPEUTICS
IF5.5
2023-03-134
OA
Doshi, Aatman S.; Cantin, Susan; Hernandez, Marylens; Srinivasan, Srimathi; Tentarelli, Sharon; Griffin, Matthew; Wang, Yanjun; Pop-Damkov, Petar; Prickett, Laura B.; Kankkonen, Cecilia; Shen, Minhui; Martin, Maryann San; Wu, Song; Castaldi, M. Paola; Ghadially, Hormas; Varnes, Jeffrey; Gales, Sonya; Henry, David; Hoover, Clare; Mele, Deanna A.; Simpson, Iain; Gangl, Eric T.; Mlynarski, Scott N.; Finlay, M. Raymond V.; Drew, Lisa; Fawell, Stephen E.; Shao, Wenlin; Schuller, Alwin G.
Optimization of an Imidazo[1,2-a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-09-0319
PRE
McCoull, William; Boyd, Scott; Brown, Martin R.; Coen, Muireann; Collingwood, Olga; Davies, Nichola L.; Doherty, Ann; Fairley, Gary; Goldberg, Kristin; Hardaker, Elizabeth; He, Guang; Hennessy, Edward J.; Hopcroft, Philip; Hodgson, George; Jackson, Anne; Jiang, Xiefeng; Karmokar, Ankur; Laine, Anne-Laure; Lindsay, Nicola; Mao, Yumeng; Markandu, Roshini; McMurray, Lindsay; McLean, Neville; Mooney, Lorraine; Musgrove, Helen; Nissink, J. Willem M.; Pflug, Alexander; Reddy, Venkatesh Pilla; Rawlins, Philip B.; Rivers, Emma; Schimpl, Marianne; Smith, Graham F.; Tentarelli, Sharon; Travers, Jon; Troup, Robert, I; Walton, Josephine; Wang, Cheng; Wilkinson, Stephen; Williamson, Beth; Winter-Holt, Jon; Yang, Dejian; Zheng, Yuting; Zhu, Qianxiu; Smith, Paul D.
Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-04-2628
OAAI
De Fusco, Claudia; Schimpl, Marianne; Borjesson, Ulf; Cheung, Tony; Collie, Iain; Evans, Laura; Narasimhan, Priyanka; Stubbs, Christopher; Vazquez-Chantada, Mercedes; Wagner, David J.; Grondine, Michael; Sanders, Matthew G.; Tentarelli, Sharon; Underwood, Elizabeth; Argyrou, Argyrides; Smith, James M.; Lynch, James T.; Chiarparin, Elisabetta; Robb, Graeme; Bagal, Sharan K.; Scott, James S.

研究方向

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E
Eric T. Gangl
H 指数:22论文数:161被引数:2,090
S
Scott N. Mlynarski
H 指数:9论文数:75被引数:1,178
B
Brian Aquila
H 指数:16论文数:50被引数:2,082
李莎 封面图
李莎
H 指数:32论文数:159被引数:3,800
P
Petar Pop-Damkov
H 指数:9论文数:88被引数:813
M
Marianne Schimpl
H 指数:26论文数:86被引数:2,047
A
Alwin G. Schuller
H 指数:37论文数:267被引数:5,361
S
Susan Cantin
H 指数:5论文数:116被引数:278
A
Aatman S. Doshi
H 指数:4论文数:56被引数:50
王海霞 封面图
王海霞
H 指数:64论文数:722被引数:1.6万