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A Chiral Pool Strategy for the Synthesis of a SMARCA2 Degrading PROTAC Lee, Miseon; Wu, Jiang-Ping; Lee, Jaehee; Wang, Jun; White, Jada A. H.; Rugg, Kyle W.; Sienkiewicz, Alexander; Lorenz, Jon C.; Greb, Peter; Bunner, Matthew H.; Hirsh, David A.; Gonnella, Nina C.; Nordstrom, Fredrik L.; Kofink, Christiane; Weinstabl, Harald; Reeves, Jonathan T. 分享 收藏
Development of a Scalable Synthesis toward a KRAS G12C Inhibitor Building Block Bearing an All-Carbon Quaternary Stereocenter, Part 1: From Discovery Route to Kilogram-Scale Production 开发具有全碳四元立体中心的KRAS G12C抑制剂构建块的可扩展合成，第1部分: 从发现途径到千克规模的生产 Leung, Joyce C.; Xu, Yibo; Radomkit, Suttipol; Lee, Jaehee; Kim, Wan Shin; Reeves, Jonathan T.; Dong, Weitong; Jang, Hwanjong; Hou, Xiaowen; Lorenz, Jon C.; Shao, Xiaole; Byrne, Denis; Johnson, Joe; Brundage, Anthony; Valentin, Clement; Beyer, Phouvieng; Dimeo, Susan V.; Qu, Bo; Li, Ruoshi; Sarvestani, Max; Song, Jinhua J. 分享 收藏
Practical Synthesis of Terminal Vinyl Fluorides Volchkov, Ivan; Powell, Brent V.; Zatolochnaya, Olga V.; Leung, Joyce C.; Pennino, Scott; Wu, Lifen; Gonnella, Nina C.; Bhaskararao, Bangaru; Kozlowski, Marisa C.; Reeves, Jonathan T. 分享 收藏
Process Development for the Synthesis of BI 1702135: A Concise Design Enabled by Selective Acylation of a 2-Aminobenzimidazole Intermediate Wu, Jiang-Ping; Dong, Wei-Tong; Chen, Chengsheng; Sienkiewicz, Alexander; Beyer, Phouvieng; Wang, Jun; Haddad, Nizar; Lorenz, Jon C.; Reeves, Jonathan T.; Bunner, Matthew H.; Gonnella, Nina C.; Weinstabl, Harald; Garavel, Geraldine 分享 收藏
Process Development of the BACE Inhibitors BI 1147560 BS and BI 1181181 MZ Li, Guisheng; Tan, Zhulin; Xu, Yibo; Sidhu, Kanwar P. S.; Qu, Bo; Herbage, Melissa A.; Eriksson, Magnus C.; Zeng, Xingzhong; Busacca, Carl A.; Desrosiers, Jean-Nicolas; Hampel, Thomas; Niemeier, Oliver; Reichel, Carsten; Dang, Mai Thi Quynh; Schoerer, Marvin; Kemmer, Dirk; Eick, Melanie; Werle, Holger; Kim, Soojin; Li, Zhibin; Venkatraman, Shankar; Jia, Lanqi; Claremon, David A.; Fuchs, Klaus; Heine, Niklas; Byrne, Denis; Narayanan, Bikshandarkoil; Sarvestani, Max; Johnson, Joe; Premasiri, Ajith; Nummy, Larry J.; Lorenz, Jon C.; Haddad, Nizar; Gonnella, Nina C.; Pennino, Scott; Krawiec, Mariusz; Senanayake, Chris H.; Buono, Frederic; Lee, Heewon; Hossain, Azad; Song, Jinhua J.; Reeves, Jonathan T. 分享 收藏
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Carbamoyl Anion Addition to Azirines Kerner, Michael J.; Kuttruff, Christian A.; Chevliakov, Maxim; Buono, Frederic G.; Gao, Donghong A.; Krawiec, Mariusz; Busacca, Carl A.; Senanayake, Chris H.; Wipf, Peter; Reeves, Jonathan T. 分享 收藏
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Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors Engelhardt, Harald; Boese, Dietrich; Petronczki, Mark; Scharn, Dirk; Bader, Gerd; Baum, Anke; Bergner, Andreas; Chong, Eugene; Doebel, Sandra; Egger, Georg; Engelhardt, Christian; Ettmayer, Peter; Fuchs, Julian E.; Gerstberger, Thomas; Gonnella, Nina; Grimm, Andreas; Grondal, Elisabeth; Haddad, Nizar; Hopfgartner, Barbara; Kousek, Roland; Krawiec, Mariusz; Kriz, Monika; Lamarre, Lyne; Leung, Joyce; Mayer, Moriz; Patel, Nitinchandra D.; Simov, Biljana Peric; Reeves, Jonathan T.; Schnitzer, Renate; Schrenk, Andreas; Sharps, Bernadette; Solca, Flavio; Stadtmueller, Heinz; Tan, Zhulin; Wunberg, Tobias; Zoephel, Andreas; McConnell, Darryl B. 分享 收藏
Rhodium-Catalyzed Addition of Aryl Boronic Acids to 2,2-Disubstituted Malononitriles Malapit, Christian A.; Caldwell, Donald R.; Luvaga, Irungu K.; Reeves, Jonathan T.; Volchkov, Ivan; Gonnella, Nina C.; Han, Zhengxu S.; Busacca, Carl A.; Howell, Amy R.; Senanayake, Chris H. 分享 收藏
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Development of a concise, scalable synthesis of a CCR1 antagonist utilizing a continuous flow Curtius rearrangement Marsini, Maurice A.; Buono, Frederic G.; Lorenz, Jon C.; Yang, Bing-Shiou; Reeves, Jonathan T.; Sidhu, Kanwar; Sarvestani, Max; Tan, Zhulin; Zhang, Yongda; Li, Ning; Lee, Heewon; Brazzillo, Jason; Nummy, Laurence J.; Chung, J. C.; Luvaga, Irungu K.; Narayanan, Bikshandarkoil A.; Wei, Xudong; Song, Jinhua J.; Roschangar, Frank; Yee, Nathan K.; Senanayake, Chris H. 分享 收藏
An Enantioselective Synthesis of an 11-β-HSD-1 Inhibitor via an Asymmetric Methallylation Catalyzed by (S)-3,3′-F2-BINOL Zhang, Yongda; Wu, Jiang-Ping; Li, Guisheng; Fandrick, Keith R.; Gao, Joe; Tan, Zhulin; Johnson, Joe; Li, Wenjie; Sanyal, Sanjit; Wang, Jun; Sun, Xiufeng; Lorenz, Jon C.; Rodriguez, Sonia; Reeves, Jonathan T.; Grinberg, Nelu; Lee, Heewon; Yee, Nathan; Lu, Bruce Z.; Senanayake, Chris H. 分享 收藏
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Efficient Asymmetric Synthesis of Structurally Diverse P-Stereogenic Phosphinamides for Catalyst Design Han, Zhengxu S.; Zhang, Li; Xu, Yibo; Sieber, Joshua D.; Marsini, Maurice A.; Li, Zhibin; Reeves, Jonathan T.; Fandrick, Keith R.; Patel, Nitinchandra D.; Desrosiers, Jean-Nicolas; Qu, Bo; Chen, Anji; Rudzinski, DiAndra M.; Samankumara, Lalith P.; Ma, Shengli; Grinberg, Nelu; Roschangar, Frank; Yee, Nathan K.; Wang, Guijun; Song, Jinhua J.; Senanayake, Chris H. 分享 收藏
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