未登录 Discovery of ARID1A loss as a patient biomarker for NXP800-A developmental activator of the integrated stress response (ISR) and inhibitor of the HSF1 pathway in ovarian cancer te Poele, Robert H.; Powers, Marissa; Sharp, Swee; de Billy, Emmanuel; Taskinen, Maria; Pellegrino, Loredana; Gowan, Sharon; Miah, Asadh; Hayes, Angela; Cheeseman, Matthew; Jones, Keith; Eccles, Suzanne; Raynaud, Florence; Clarke, Paul; Workman, Paul 分享 收藏
Using acquired resistance to explore the mechanism of action of the integrated stress response/GCN2 activator NXP800-A new developmental agent for platinum-resistant ARID1A mutant ovarian cancer Powers, Marissa V.; Hodgson, Rachel; Sharp, Swee Y.; Roe, Toby; Allen, K. Elizabeth; Campbell, Susan; te Poele, Robert; Cheeseman, Matthew; Jones, Keith; Clarke, Paul A.; Workman, Paul 分享 收藏
Activation of the integrated stress response by NXP800, an orally available, clinical-stage, investigational agent in ARID1A-mutated, platinum resistant ovarian cancer Powers, Marissa V.; Swap, Swee Y.; te Poele, Robert; Lampraki, Eirini-Maria; Roe, Toby; Pellegrino, Loredana; Taskinen, Maria; Eccles, Suzenne; Raynaud, Florence; Cheeseman, Matthew; Jones, Keith; Clarke, Paul A.; Workman, Paul 分享 收藏
Activation of the integrated stress response by the developmental HSF1 pathway inhibitor NXP800 Powers, Marissa V.; Sharp, Swee Y.; Lampraki, Eirini-Maria; Roe, Toby; Pellegrino, Loredana; Taskinen, Maria; Poele, Robert Te; Raynaud, Florence; Eccles, Suzanne; Cheeseman, Matthew; Jones, Keith; Clarke, Paul A.; Workman, Paul 分享 收藏
HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies Pasqua, A. Elisa; Sharp, Swee Y.; Chessum, Nicola E. A.; Hayes, Angela; Pellegrino, Loredana; Tucker, Michael J.; Miah, Asadh; Wilding, Birgit; Evans, Lindsay E.; Rye, Carl S.; Mok, N. Yi; Liu, Manjuan; Henley, Alan T.; Gowan, Sharon; De Billy, Emmanuel; te Poele, Robert; Powers, Marissa; Eccles, Suzanne A.; Clarke, Paul A.; Raynaud, Florence I.; Workman, Paul; Jones, Keith; Cheeseman, Matthew D. 分享 收藏
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A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D (vol 27, pg 1036, 2008) Rayter, S.; Elliott, R.; Travers, J.; Rowlands, M. G.; Richardson, T. B.; Boxall, K.; Jones, K.; Linardopoulos, S.; Workman, P.; Aherne, W.; Lord, C. J.; Ashworth, A. 分享 收藏
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Privileged Structures and Polypharmacology within and between Protein Families Meyers, Joshua; Chessum, Nicola E. A.; Ali, Salyha; Mok, N. Yi; Wilding, Birgit; Pasqua, A. Elisa; Rowlands, Martin; Tucker, Michael J.; Evans, Lindsay E.; Rye, Carl S.; O'Fee, Lisa; Le Bihan, Yann-Vai; Burke, Rosemary; Carter, Michael; Workman, Paul; Blagg, Julian; Brown, Nathan; van Montfort, Rob L. M.; Jones, Keith; Cheeseman, Matthew D. 分享 收藏
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Confirmation of in-cell target engagement using the proteolysis targeting chimeras (PROTACs) against pirin Sharp, Swee Y.; Chessum, Nicola E.; Caldwell, John J.; Powers, Marissa V.; Pasqua, A. Elisa; Wilding, Birgit; Collins, Ian; Ozer, Bugra; Rowlands, Martin; Stubbs, Mark; Burke, Rosemary; van Montfort, Rob L.; Cheeseman, Matthew D.; Clarke, Paul A.; Workman, Paul; Jones, Keith 分享 收藏
HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target Fok, Jacqueline H. L.; Hedayat, Somaieh; Zhang, Lei; Aronson, Lauren I.; Mirabella, Fabio; Pawlyn, Charlotte; Bright, Michael D.; Wardell, Christopher P.; Keats, Jonathan J.; De Billy, Emmanuel; Rye, Carl S.; Chessum, Nicola E. A.; Jones, Keith; Morgan, Gareth J.; Eccles, Suzanne A.; Workman, Paul; Davies, Faith E. 分享 收藏
Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766) Chessum, Nicola E. A.; Sharp, Swee Y.; Caldwell, John J.; Pasqua, A. Elisa; Wilding, Birgit; Colombano, Giampiero; Collins, Ian; Ozer, Bugra; Richards, Meirion; Rowlands, Martin; Stubbs, Mark; Burke, Rosemary; McAndrew, P. Craig; Clarke, Paul A.; Workman, Paul; Cheeseman, Matthew D.; Jones, Keith 分享 收藏
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Discovery of chemical probe CCT251236: An orally bioavailable efficacious pirin ligand from an HSF1 phenotypic screen Cheeseman, Matthew D.; Chessum, Nicola E.; Rye, Carl S.; Pasqua, Elisa A.; Tucker, Michael J.; Wilding, Birgit; Evans, Lindsay E.; Lepri, Susan; Richards, Meirion; Sharp, Swee Y.; Ali, Salyha; Rowlands, Martin; O'Fee, Lisa; Miah, Asadh; Hayes, Angela; Henley, Alan T.; Powers, Marissa; te Poele, Robert; De Billy, Emmanuel; Pellegrino, Loredana; Raynaud, Florence; Burke, Rosemary; van Montfort, Robert L.; Eccles, Suzanne A.; Jones, Keith; Workman, Paul 分享 收藏
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Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen Cheeseman, Matthew D.; Chessum, Nicola E. A.; Rye, Carl S.; Pasqua, A. Elisa; Tucker, Michael J.; Wilding, Birgit; Evans, Lindsay E.; Lepri, Susan; Richards, Meirion; Sharp, Swee Y.; Ali, Salyha; Rowlands, Martin; O'Fee, Lisa; Miah, Asadh; Hayes, Angela; Henley, Alan T.; Powers, Marissa; te Poele, Robert; De Billy, Emmanuel; Pellegrino, Loredana; Raynaud, Florence; Burke, Rosemary; van Montfort, Rob L. M.; Eccles, Suzanne A.; Workman, Paul; Jones, Keith 分享 收藏
A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms Jones, Alan M.; Westwood, Isaac M.; Osborne, James D.; Matthews, Thomas P.; Cheeseman, Matthew D.; Rowlands, Martin G.; Jeganathan, Fiona; Burke, Rosemary; Lee, Diane; Kadi, Nadia; Liu, Manjuan; Richards, Meirion; McAndrew, Craig; Yahya, Norhakim; Dobson, Sarah E.; Jones, Keith; Workman, Paul; Collins, Ian; van Montfort, Rob L. M. 分享 收藏
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