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A

Alan Ashworth

University of California San Francisco
H指数:121
被引数:6.6万

个人简介

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教育背景

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工作经历

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荣誉奖项

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Development of a random background to understand ligand optimization

开发随机背景以理解配体优化

Nature
IF48.5
2026-09-160
OAAI
Xinyu Xu; Olivier Mailhot; Galen J. Correy; Xi-Ping Huang; Joao M. Braz; Da Shi; Karthik Srinivasan; Kara Zielinski; Yuliia Holota; Yuliia Kuziv; Christos Iliopoulos-Tsoutsouvas; Nathan D. Levinzon; Yagmur U. Doruk; Moira M. Rachman; Morgan E. Diolaiti; Maisie G. V. Stevens; Fangyu Liu; Katie L. Holland; Harald Hübner; Jing Wang; Yujin Wu; Alan Ashworth; Alexandros Makriyannis; Yuqi Zhang; Yurii S. Moroz; Peter Gmeiner; Robert Abel; Aashish Manglik; Allan I. Basbaum; Bryan L. Roth; James S. Fraser; Brian K. Shoichet
Publisher Correction: Targeting cancer-specific mutations with RNA-triggered chromatin shredding

Publisher Correction: 靶向癌症特异性突变，利用RNA触发的染色质切碎

Nature
IF48.5
2026-08-140
PRE
Jingkun Zeng; Zhiyuan Cheng; Huadong Chen; Zhaojun Wang; Jared Thompson; Kadin T. Crosby; Hesong Han; Arushi Singhal; Wayne Ngo; Chenglong Xia; Daniel Rosas-Rivera; Zeyuan Zhang; Min Hyung Kang; Ying Mao; Morgan E. Diolaiti; Giselle C. Lee; John F. X. Diffley; Yixuan Song; Longhui Qiu; Nathan M. Krah; Niren Murthy; Ryan N. Jackson; Yang Liu; Alan Ashworth; Jennifer A. Doudna
Targeting Cancer-Specific Mutations with RNA-Triggered Chromatin Shredding

利用RNA触发的染色质降解靶向癌症特异性突变

Nature
IF48.5
2026-06-080
PRE
Jingkun Zeng; Zhiyuan Cheng; Huadong Chen; Zhaojun Wang; Jared Thompson; Kadin T. Crosby; Hesong Han; Arushi Singhal; Wayne Ngo; Chenglong Xia; Daniel Rosas-Rivera; Zeyuan Zhang; Min Hyung Kang; Ying Mao; Morgan E. Diolaiti; Giselle C. Lee; John F. X. Diffley; Yixuan Song; Longhui Qiu; Nathan M. Krah; Niren Murthy; Ryan N. Jackson; Yang Liu; Alan Ashworth; Jennifer A. Doudna
Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy In Vivo
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-12-010
PRE
Jaishankar, Priyadarshini; Correy, Galen J.; Matsui, Yusuke; Togo, Takaya; Rachman, Moira M.; Stevens, Maisie G. V.; Hantz, Eric R.; Zheng, Jeffrey; Diolaiti, Morgan E.; Montano, Mauricio; Taha, Taha Y.; Rosecrans, Julia; Pampel, Julius; Krogan, Nevan J.; Shoichet, Brian K.; Ashworth, Alan; Ott, Melanie; Fraser, James S.; Renslo, Adam R.
The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2

Mac1 ADP-核糖基水解酶是SARS-CoV-2的 therapeutic target。

ELIFE
IF0
2025-11-191
OA
Suryawanshi, Rahul K.; Jaishankar, Priyadarshini; Correy, Galen J.; Rachman, Moira M.; O'leary, Patrick C.; Taha, Taha Y.; Matsui, Yusuke; Zapatero-Belinchon, Francisco J.; Mccavitt-Malvido, Maria; Doruk, Yagmur U.; Stevens, Maisie Gv; Diolaiti, Morgan E.; Jogalekar, Manasi P.; Chen, Huadong; Richards, Alicia L.; Kongpracha, Pornparn; Bali, Sofia; Montano, Mauricio; Rosecrans, Julia; Matthay, Michael; Togo, Takaya; Gonciarz, Ryan L.; Gopalkrishnan, Saumya; Neitz, R. Jeffrey; Krogan, Nevan J.; Swaney, Danielle L.; Shoichet, Brian K.; Ott, Melanie; Renslo, Adam R.; Ashworth, Alan; Fraser, James S.
Coordinated protein modules define DNA damage responses to carboplatin at single-cell resolution in human ovarian carcinoma models

协调的蛋白质模块在人类卵巢癌模型中定义了卡铂诱导的DNA损伤反应的单细胞分辨率。

Cell Reports Medicine
IF10.6
2025-08-220
OAAI
Jacob S. Bedia; Antonio Delgado-Gonzalez; Ying-Wen Huang; Veronica D. Gonzalez; Ionut-Gabriel Funingana; Zainab Rahil; Alyssa Mike; Alexis Lowber; Maria Vias; Alan Ashworth; James D. Brenton; Wendy J. Fantl
Correction: Assessing the Value of New Antimicrobials: Evaluations of Cefiderocol and Ceftazidime-Avibactam to Inform Delinked Payments by the NHS in England

更正：评估新抗菌药物的价值：评估铁载体头孢菌素(Cefiderocol)和头孢他啶-阿维巴坦(Ceftazidime-Avibactam)以供英格兰国家医疗服务体系(NHS)进行脱钩支付决策

Applied Health Economics and Health Policy
IF3.3
2025-06-020
OAAI
Beth Woods; Ben Kearns; Laetitia Schmitt; Dina Jankovic; Claire Rothery; Sue Harnan; Jean Hamilton; Alison Scope; Shijie Ren; Laura Bojke; Mark Wilcox; William Hope; Colm Leonard; Philip Howard; David Jenkins; Alan Ashworth; Andrew Bentley; Mark Sculpher
Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy
CANCER DISCOVERY
IF33.3
2024-05-101
PRE
Choudhury, Abrar; Cady, Martha A.; Lucas, Calixto-Hope G.; Najem, Hinda; Phillips, Joanna J.; Palikuqi, Brisa; Zakimi, Naomi; Joseph, Tara; Birrueta, Janeth O.; Chen, William C.; Bush, Nancy A. Oberheim; Hervey-Jumper, Shawn L.; Klein, Ophir D.; Toedebusch, Christine M.; Horbinski, Craig M.; Magill, Stephen T.; Bhaduri, Aparna; Perry, Arie; Dickinson, Peter J.; Heimberger, Amy B.; Ashworth, Alan; Crouch, Elizabeth E.; Raleigh, David R.
Generation and comparative analysis of an Itga8-CreERT2 mouse with preferential activity in vascular smooth muscle cells (vol 1, pg 1084, 2022)
cardiovascular research
IF10.8
2023-06-090
OA
Warthi, Ganesh; Faulkner, Jessica L.; Doja, Jaser; Ghanam, Amr R.; Gao, Pan; Yang, Allison C.; Slivano, Orazio J.; Barris, Candee T.; Kress, Taylor C.; Zawieja, Scott D.; Griffin, Susan H.; Xie, Xiaoling; Ashworth, Alan; Christie, Christine K.; Bryant, William B.; Kumar, Ajay; Davis, Michael J.; Long, Xiaochun; Gan, Lin; de Chantemele, Eric J. Belin; Lyu, Qing R.; Miano, Joseph M.

研究方向

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R
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James Campbell
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M
Morgan E. Diolaiti
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