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C

Cheol K. Chung

merck and co
H指数:20
被引数:1,299

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Biocatalytic cascades enable manufacture of the macrocyclic peptide enlicitide

生物催化级联实现大环肽enlicitide的制造

Science
IF45.8
2026-05-070
PRE
Pilot-Scale Operation and Characterization of an Organolithium-Mediated Coupling Reaction in Flow to Form a Ketone Intermediate on the Route to Nemtabrutinib
2024-05-091
PRE
Development of a Green and Sustainable Manufacturing Process for a Key Intermediate to Nemtabrutinib (MK-1026): Sequential Deprotonation-Lithiation as a Batch-Flow Process
2024-05-090
PRE
Use of a Dynamic Flow Platform To Translate a Batch Immobilized Transaminase Process to a Packed Bed Reactor for the Synthesis of an Intermediate of Nemtabrutinib

使用动态流动平台将分批固定化转氨酶过程转化为填充床反应器,以合成内姆他布替尼中间体

2023-12-154
PRE
Manufacturing Process Development for the Biaryl Ether Fragment of Nemtabrutinib (MK-1026)

Nemtabrutinib (MK-1026) 的联芳基醚片段的制造工艺开发

2023-10-242
PRE
Leveraging Synergistic Solubility in the Development of a Direct Isolation Process for Nemtabrutinib

在开发Nemtabrutinib的直接隔离过程中利用协同溶解度

2023-03-107
PRE
Diverse Catalytic Reactions for the Stereoselective Synthesis ofCyclic Dinucleotide MK-1454
2022-03-2530
PRE
Efficient Manufacturing Process for the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant) via a Crystallization-Driven Diastereoselective Pictet-Spengler Condensation

通过结晶驱动的非对映选择性pictet-spengler缩合的选择性雌激素受体降解GDC-9545 (giedestrant) 的有效制造工艺

2021-11-095
PREAI
First-Generation Asymmetric Synthesis of the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant) Featuring a Highly Efficient Pictet-Spengler Reaction and a C-N Coupling Reaction

选择性雌激素受体降解GDC-9545 (Giredestrant) 的第一代不对称合成,具有高效的pictet-spengler反应和c-n偶联反应

2021-11-053
PREAI