Q1291H-CFTR molecular dynamics simulations and ex vivo theratyping in nasal epithelial models and clinical response to elexacaftor/tezacaftor/ivacaftor in a Q1291H/F508del patientFRONTIERS IN MOLECULAR BIOSCIENCESIF42023-06-011OAAI
Computational Evaluation of N-Based Transannular Interactions in Some Model Fused Medium-Sized Heterocyclic Systems and Implications for Drug DesignMOLECULESIF4.62023-02-083OAAI
Molecular Dynamics and Theratyping in Airway and Gut Organoids Reveal R352Q-CFTR Conductance Defect气道和肠道类器官的分子动力学和热异常揭示了R352Q-CFTR电导缺陷AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGYIF5.32022-07-018OAAI
Discovery of neuroprotective agents that inhibit human prolyl hydroxylase PHD2BIOORGANIC & MEDICINAL CHEMISTRYIF32021-05-015OAAI
Exploration of the Differences between Amine and Thiolate Addition to AcetylenedicarboxylatesJOURNAL OF ORGANIC CHEMISTRYIF3.62019-10-160PREAI
Molecular targeting for treatment of human T-lymphotropic virus type 1 infection分子靶向治疗人类T淋巴病毒1型感染BIOMEDICINE & PHARMACOTHERAPYIF7.52019-01-0126OAAI
Design and Synthesis of Lactams Derived from Mucochloric and Mucobromic Acids as Pseudomonas aeruginosa Quorum Sensing InhibitorsMOLECULESIF4.62018-05-0720OAAI
Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye DiseaseACS CHEMICAL BIOLOGYIF3.82017-02-0683OAAI
Synthesis of antimicrobial glucosamides as bacterial quorum sensing mechanism inhibitorsBIOORGANIC & MEDICINAL CHEMISTRYIF32017-02-0116PREAI
FMS-like tyrosine kinase 3 (FLT3) inhibitors: Molecular docking and experimental studiesEUROPEAN JOURNAL OF PHARMACOLOGYIF4.72016-04-0121PREAI
From indole to pyrrole, furan, thiophene and pyridine: Search for novel small molecule inhibitors of bacterial transcription initiation complex formationBIOORGANIC & MEDICINAL CHEMISTRYIF32016-03-0120PREAI
Synthesis and biological activity of novel mono-indole and mono-benzofuran inhibitors of bacterial transcription initiation complex formationBIOORGANIC & MEDICINAL CHEMISTRYIF32015-04-0135PREAI
Human α1-adrenoceptor subtype selectivity of substituted homobivalent 4-aminoquinolinesBIOORGANIC & MEDICINAL CHEMISTRYIF32014-11-011PREAI
An aspartate in the second extracellular loop of the α1B adrenoceptor regulates agonist bindingEUROPEAN JOURNAL OF PHARMACOLOGYIF4.72014-06-018PREAI
Stereoselective Fluorination Alters the Geometry of a Cyclic Peptide: Exploration of Backbone-Fluorinated Analogues of Unguisin AANGEWANDTE CHEMIE-INTERNATIONAL EDITIONIF16.92014-05-2159OAAI
Synthesis and biological evaluation of 2,5-di(7-indolyl)-1,3, 4-oxadiazoles, and 2-and 7-indolyl 2-(1,3,4-thiadiazolyl)ketones as antimicrobialsBIOORGANIC & MEDICINAL CHEMISTRYIF32014-03-0123PREAI
Development of purely structure-based pharmacophores for the topoisomerase I-DNA-ligand binding pocketJOURNAL OF COMPUTER-AIDED MOLECULAR DESIGNIF3.12013-12-019OA
Inhibitors of Bacterial Transcription Initiation Complex FormationACS CHEMICAL BIOLOGYIF3.82013-07-0561OA
α1-Adrenoceptor and serotonin 5-HT1A receptor affinity of homobivalent 4-aminoquinoline compounds: An investigation of the effect of linker lengthBIOCHEMICAL PHARMACOLOGYIF5.62013-05-017PREAI
5-HT1A receptor pharmacophores to screen for off-target activity of α1-adrenoceptor antagonistsJOURNAL OF COMPUTER-AIDED MOLECULAR DESIGNIF3.12013-04-278PREAI