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Enhancing the Small-Scale Screenable Biological Space beyond Known Chemogenomics Libraries with Gray Chemical Matter-Compounds with Novel Mechanisms from High-Throughput Screening Profiles Thomas, Jason R.; Shelton, Claude; Murphy, Jason; Brittain, Scott; Bray, Mark-Anthony; Aspesi, Peter; Concannon, John; King, Frederick J.; Ihry, Robert J.; Ho, Daniel J.; Henault, Martin; Hadjikyriacou, Andrea; Neri, Marilisa; Sigoillot, Frederic D.; Pham, Helen T.; Shum, Matthew; Barys, Louise; Jones, Michael D.; Martin, Eric J.; Blechschmidt, Anke; Rieffel, Sebastien; Troxler, Thomas J.; Mapa, Felipa A.; Jenkins, Jeremy L.; Jain, Rishi K.; Kutchukian, Peter S.; Schirle, Markus; Renner, Steffen 分享 收藏
Screening in serum-derived medium reveals differential response to compounds targeting metabolism Abbott, Keene L.; Ali, Ahmed; Casalena, Dominick; Do, Brian T.; Ferreira, Raphael; Cheah, Jaime H.; Soule, Christian K.; Deik, Amy; Kunchok, Tenzin; Schmidt, Daniel R.; Renner, Steffen; Honeder, Sophie E.; Wu, Michelle; Chan, Sze Ham; Tseyang, Tenzin; Stoltzfus, Andrew T.; Michel, Sarah L. J.; Greaves, Daniel; Hsu, Peggy P.; Ng, Christopher W.; Zhang, Chelsea J.; Farsidjani, Ali; Kent, Johnathan R.; Madariaga, Maria Lucia L.; Gramatikov, Iva Monique T.; Matheson, Nicholas J.; Lewis, Caroline A.; Clish, Clary B.; Rees, Matthew G.; Roth, Jennifer A.; Griner, Lesley Mathews; Muir, Alexander; Auld, Douglas S.; Heiden, Matthew G. Vander 分享 收藏
Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis Neuwirt, Emilia; Magnani, Giovanni; Cikovic, Tamara; Woehrle, Svenja; Fischer, Larissa; Kostina, Anna; Flemming, Stephan; Fischenich, Nora J.; Saller, Benedikt S.; Gorka, Oliver; Renner, Steffen; Agarinis, Claudia; Parker, Christian N.; Boettcher, Andreas; Farady, Christopher J.; Kesselring, Rebecca; Berlin, Christopher; Backofen, Rolf; Rodriguez-Franco, Marta; Kreutz, Clemens; Prinz, Marco; Tholen, Martina; Reinheckel, Thomas; Ott, Thomas; Gross, Christina J.; Jost, Philipp J.; Gross, Olaf 分享 收藏
DRUG-seq Provides Unbiased Biological Activity Readouts for Neuroscience Drug Discovery Li, Jingyao; Ho, Daniel J.; Henault, Martin; Yang, Chian; Neri, Marilisa; Ge, Robin; Renner, Steffen; Mansur, Leandra; Lindeman, Alicia; Kelly, Brian; Tumkaya, Tayfun; Ke, Xiaoling; Soler-Llavina, Gilberto; Shanker, Gopi; Russ, Carsten; Hild, Marc; Keller, Caroline Gubser; Jenkins, Jeremy L.; Worringer, Kathleen A.; Sigoillot, Frederic D.; Ihry, Robert J. 分享 收藏
BET bromodomain inhibitors regulate keratinocyte plasticity Schutzius, Gabi; Kolter, Christian; Bergling, Sebastian; Tortelli, Federico; Fuchs, Florian; Renner, Steffen; Guagnano, Vito; Cotesta, Simona; Rueeger, Heinrich; Faller, Michael; Bouchez, Laure; Salathe, Adrian; Nigsch, Florian; Richards, Shola M.; Louis, Malvina; Gruber, Viktoria; Aebi, Alexandra; Turner, Jonathan; Grandjean, Frederic; Li, Jun; Dimitri, Chris; Thomas, Jason R.; Schirle, Markus; Blank, Jutta; Drueckes, Peter; Vaupel, Andrea; Tiedt, Ralph; Manley, Paul W.; Klopp, Julia; Hemmig, Rene; Zink, Florence; Leroy, Nelly; Carbone, Walter; Roma, Guglielmo; Keller, Caroline Gubser; Dales, Natalie; Beyerbach, Armin; Zimmerlin, Alfred; Bonenfant, Debora; Terranova, Remi; Berwick, Amy; Sahambi, Sukhdeep; Reynolds, Aimee; Jennings, Lori L.; Ruffner, Heinz; Tarsa, Peter; Bouwmeester, Tewis; Driver, Vickie; Frederiksen, Mathias; Lohmann, Felix; Kirkland, Susan 分享 收藏
Gene-signature-derived IC50s/EC50s reflect the potency of causative upstream targets and downstream phenotypes Renner, Steffen; Bergsdorf, Christian; Bouhelal, Rochdi; Koziczak-Holbro, Magdalena; Amati, Andrea Marco; Techer-Etienne, Valerie; Flotte, Ludivine; Reymann, Nicole; Kapur, Karen; Hoersch, Sebastian; Oakeley, Edward James; Schuffenhauer, Ansgar; Gubler, Hanspeter; Lounkine, Eugen; Farmer, Pierre 分享 收藏
DRUG-seq for miniaturized high-throughput transcriptome profiling in drug discovery Ye, Chaoyang; Ho, Daniel J.; Neri, Marilisa; Yang, Chian; Kulkarni, Tripti; Randhawa, Ranjit; Henault, Martin; Mostacci, Nadezda; Farmer, Pierre; Renner, Steffen; Ihry, Robert; Mansur, Leandra; Keller, Caroline Gubser; McAllister, Gregory; Hild, Marc; Jenkins, Jeremy; Kaykas, Ajamete 分享 收藏
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Development of Highly Potent Inhibitors of the Ras-Targeting Human Acyl Protein Thioesterases Based on Substrate Similarity Design Hedberg, Christian; Dekker, Frank J.; Rusch, Marion; Renner, Steffen; Wetzel, Stefan; Vartak, Nachiket; Gerding-Reimers, Claas; Bon, Robin S.; Bastiaens, Philippe I. H.; Waldmann, Herbert 分享 收藏
Ask the experts: focus on computational chemistry Bajorath, Juergen; Barreca, Maria Letizia; Bender, Andreas; Bryce, Richard; Hutter, Michael; Laggner, Christian; Laughton, Charles; Martin, Yvonne; Mitchell, John; Padova, Alessandro; Renner, Steffen; Selzer, Paul M.; Sherman, Woody; Sippl, Wolfgang; Taft, Carlton; Tuccinardi, Tiziano; Vistoli, Giulio; Willett, Peter 分享 收藏
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Anticancer Properties of an Important Drug Lead Podophyllotoxin Can Be Efficiently Mimicked by Diverse Heterocyclic Scaffolds Accessible via One-Step Synthesis Magedov, Igor V.; Frolova, Liliya; Manpadi, Madhuri; Bhoga, Uma Devi; Tang, Hong; Evdoldmov, Nikolai M.; George, Olivia; Georgiou, Kathy Hadje; Renner, Steffen; Getlik, Matthaeus; Kinnibrugh, Tiffany L.; Fernandes, Manuel A.; Van Slambrouck, Severine; Steelant, Wim F. A.; Shuster, Charles B.; Rogelj, Snezna; van Otterlo, Willem A. L.; Kornienko, Alexander 分享 收藏
Recent trends and observations in the design of high-quality screening collections Renner, Steffen; Popov, Maxim; Schuffenhauer, Ansgar; Roth, Hans-Joerg; Breitenstein, Werner; Marzinzik, Andreas; Lewis, Ian; Krastel, Philipp; Nigsch, Florian; Jenkins, Jeremy; Jacoby, Edgar 分享 收藏
A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-Pyrones Wetzel, Stefan; Wilk, Wolfram; Chammaa, Samy; Sperl, Bianca; Roth, Anke G.; Yektaoglu, Aybike; Renner, Steffen; Berg, Thorsten; Arenz, Christoph; Giannis, Athanassios; Oprea, Tudor I.; Rauh, Daniel; Kaiser, Markus; Waldmann, Herbert 分享 收藏
Small-molecule inhibition of APT1 affects Ras localization and signaling Dekker, Frank J.; Rocks, Oliver; Vartak, Nachiket; Menninger, Sascha; Hedberg, Christian; Balamurugan, Rengarajan; Wetzel, Stefan; Renner, Steffen; Gerauer, Marc; Schoelermann, Beate; Rusch, Marion; Kramer, John W.; Rauh, Daniel; Coates, Geoffrey W.; Brunsveld, Luc; Bastiaens, Philippe I. H.; Waldmann, Herbert 分享 收藏
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