Jorge Esquivias

janssen pharmaceutica

H指数:18

被引数:1,655

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The role of cytochrome bc1 inhibitors in future tuberculosis treatment regimens

细胞色素bc1抑制剂的未来结核病治疗方案中的作用

Nature Communications

IF15.7

2025-10-220

OAAI

Clara Aguilar-Pérez; Anne J. Lenaerts; Cristina Villellas; Jerome Guillemont; John Dallow; Hannah Painter; Nicole C. Ammerman; Anis Hassan; Guillaume Golovkine; Laure Brock; Sylvie Sordello; Aurélie Chauffour; Alexandra Aubry; Thi Cuc Mai; Sarah Wong; Taane G. Clark; Kiyean Nam; Jeongjun Kim; Jinho Choi; Marjolein Crabbe; Jorge Esquivias; Nacer Lounis; Bart Stoops; Katie Amssoms; Jose M. Bartolome-Nebreda; Veronica Gruppo; Gregory T. Robertson; Nicolas Veziris; Anna M. Upton; Eric L. Nuermberger; Vivian Cox; Lluis Ballell; Benny Baeten; Anil Koul; Alexander S. Pym; Richard J. Wall; Dirk A. Lamprecht

Targeting de novo purine biosynthesis for tuberculosis treatment

靶向从头嘌呤生物合成以治疗结核病

Nature

IF48.5

2025-06-180

OAAI

Dirk A. Lamprecht; Richard J. Wall; Annelies Leemans; Barry Truebody; Joke Sprangers; Patricia Fiogbe; Cadi Davies; Jennefer Wetzel; Stijn Daems; William Pearson; Vanessa Pillay; Samantha Saylock; M. Daniel Ricketts; Ellie Davis; Adam Huff; Tsehai Grell; Shiming Lin; Michelle Gerber; Ann Vos; John Dallow; Sam J. Willcocks; Christine Roubert; Stéphanie Sans; Amandine Desorme; Nicolas Chappat; Aurélie Ray; Mariana Pereira Moraes; Tracy Washington; Hope D’Erasmo; Pavankumar Sancheti; Melissa Everaerts; Mario Monshouwer; Jorge Esquivias; Gerald Larrouy-Maumus; Ruxandra Draghia Akli; Helen Fletcher; Alexander S. Pym; Bree B. Aldridge; Jansy P. Sarathy; Kathleen W. Clancy; Bart Stoops; Neeraj Dhar; Adrie J. C. Steyn; Paul Jackson; Clara Aguilar-Pérez; Anil Koul

GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2022-06-2128

Nuermberger, Eric L.; Martinez-Martinez, Maria Santos; Sanz, Olalla; Urones, Beatriz; Esquivias, Jorge; Soni, Heena; Tasneen, Rokeya; Tyagi, Sandeep; Li, Si-Yang; Converse, Paul J.; Boshoff, Helena I.; Robertson, Gregory T.; Besra, Gurdyal S.; Abrahams, Katherine A.; Upton, Anna M.; Mdluli, Khisimuzi; Boyle, Gary W.; Turner, Sam; Fotouhi, Nader; Cammack, Nicholas C.; Siles, Juan Miguel; Alonso, Marta; Escribano, Jaime; Lelievre, Joel; Rullas-Trincado, Joaquin; Perez-Herran, Esther; Bates, Robert H.; Maher-Edwards, Gareth; Barros, David; Ballell, Lluis; Jimenez, Elena

Lack of Specificity of Phenotypic Screens for Inhibitors of the Mycobacterium tuberculosis FAS-II System

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2020-12-161

OAAI

Exploring the SAR of the β-Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite

ACS INFECTIOUS DISEASES

IF3.8

2020-03-2015

PREAI

Easy-To-Synthesize Spirocyclic Compounds Possess Remarkable in Vivo Activity against Mycobacterium tuberculosis

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-11-2022

OAAI

Guardia, Ana; Baiget, Jessica; Cacho, Monica; Perez, Arancha; Ortega-Guerra, Montserrat; Nxumalo, Winston; Khanye, Setshaba D.; Rullas, Joaquin; Ortega, Fatima; Jimenez, Elena; Perez-Herran, Esther; Fraile-Gabaldon, Maria Teresa; Esquivias, Jorge; Fernandez, Raquel; Porras-De Francisco, Esther; Encinas, Lourdes; Alonso, Marta; Giordano, Ilaria; Rivero, Cristina; Miguel-Siles, Juan; Osende, Javier G.; Badiola, Katrina A.; Rutledge, Peter J.; Todd, Matthew H.; Remuinan, Modesto; Alemparte, Carlos

Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface

SCIENTIFIC REPORTS

IF3.9

2017-08-2553

OAAI

Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen

SCIENTIFIC REPORTS

IF3.9

2016-12-1627

OAAI

Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

JOURNAL OF MEDICINAL CHEMISTRY