David Marcoux

triana biomedicines

H指数:15

被引数:1,018

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TRI-611, a selective, brain-penetrant molecular glue degrader of ALK

TRI-611，一种选择性、可透过血脑屏障的ALK分子胶降解剂

Nature

IF48.5

2026-09-090

PRE

Discovery of Non-prostanoid EP4 Agonists for the Treatment of Inflammatory Bowel Disease

非前列腺素类EP4激动剂的发现及其在炎症性肠病治疗中的应用

Journal of Medicinal Chemistry

IF6.8

2026-04-030

PRE

Heidi L. Perez; Sunita Dewnani; Steven A. Spronk; Hai-Yun Xiao; Ling Li; Mojgan Abousleiman; Chi Shing Sum; Margarita Garcia-Calvo; Fei Yu; Brian Anderson; Brian J. Arey; Riyaz Khan; Chandra Sekhar Bokka; Yazh Muthukumar; Kaushik Ghosh; Tao Wang; Carol M. Krause; Judith Murray; Trevor Vernon; Ramakrishna Chandran; Mary T. Obermeier; Victor R. Guarino; Tamara King; Julia Li; Laura Armstrong; Purnima Khandelwal; Margaret Prack; David Marcoux; Samuel Gerritz; William J. Pitts; Alaric J. Dyckman; Robert M. Borzilleri; Carolyn Dzierba; Jenny H. Xie; Mary Struthers; Patrick Shaw; Derek Holmes; Amy C. Hart; Trevor C. Sherwood

Tricyclic-Carbocyclic RORγt Inverse Agonists-Discovery of BMS-986313

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-02-1612

PREAI

Discovery of Annulating Reagents Enabling the One-Step and Highly Stereoselective Synthesis of Cyclopentyl and Cyclohexyl Cores

ORGANIC LETTERS

IF5

2020-12-223

PREAI

Aryl Ether-Derived Sphingosine-1-Phosphate Receptor (S1P1) Modulators: Optimization of the PK, PD, and Safety Profiles

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2020-08-115

OAAI

Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2020-03-3137

OAAI

Cherney, Robert J.; Cornelius, Lyndon A. M.; Srivastava, Anurag; Weigelt, Carolyn A.; Marcoux, David; Duan, James J-W; Shi, Qing; Batt, Douglas G.; Liu, Qingjie; Yip, Shiuhang; Wu, Dauh-Rurng; Ruzanov, Max; Sack, John; Khan, Javed; Wang, Jinhong; Yarde, Melissa; Cvijic, Mary Ellen; Mathur, Arvind; Li, Sha; Shuster, David; Khandelwal, Purnima; Borowski, Virna; Xie, Jenny; Obermeier, Mary; Fura, Aberra; Stefanski, Kevin; Cornelius, Georgia; Tino, Joseph A.; Macor, John E.; Salter-Cid, Luisa; Denton, Rex; Zhao, Qihong; Carter, Percy H.; Dhar, T. G. Murali

One-Step Diastereoselective Pyrrolidine Synthesis Using a Sulfinamide Annulating Reagent

ORGANIC LETTERS

IF5

2019-10-2414

PREAI

Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt-Identification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2019-10-2233

PREAI

Marcoux, David; Duan, James J. -W.; Shi, Qing; Cherney, Robert J.; Srivastava, Anurag S.; Cornelius, Lyndon; Batt, Douglas G.; Liu, Qingjie; Beaudoin-Bertrand, Myra; Weigelt, Carolyn A.; Khandelwal, Purnima; Vishwakrishnan, Sureshbabu; Selvakumar, Kumaravel; Karmakar, Ananta; Gupta, Arun Kumar; Basha, Mushkin; Ramlingam, Sridharan; Manjunath, Naveen; Vanteru, Sridhar; Karmakar, Sukhen; Maddala, Nageswara; Vetrichelvan, Muthalagu; Gupta, Anuradha; Rainpulla, Richard A.; Mathur, Arvind; Yip, Shiuhang; Li, Peng; Wu, Dauh-Rurng; Khan, Javed; Ruzanov, Max; Sack, John S.; Wang, Jinhong; Yarde, Melissa; Cvijic, Mary Ellen; Li, Sha; Shuster, David J.; Borowski, Virna; Xie, Jenny H.; McIntyre, Kim W.; Obermeier, Mary T.; Fura, Aberra; Stefanski, Kevin; Cornelius, Georgia; Hynes, John, Jr.; Tino, Joseph A.; Macor, John E.; Salter-Cid, Luisa; Denton, Rex; Zhao, Qihong; Carter, Percy H.; Dhare, T. G. Murali

Protected Chloroethyl and Chloropropyl Amines as Conformationally Unrestricted Annulating Reagents

ORGANIC LETTERS

IF5

2017-12-2810

PREAI

Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (P13Kδ) Inhibitor for the Treatment of Immunological Disorders

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-06-0517

PREAI

Liu, Qingjie; Shi, Qing; Marcoux, David; Batt, Douglas G.; Cornelius, Lyndon; Qin, Lan-Ying; Ruan, Zheming; Neels, James; Beaudoin-Bertrand, Myra; Srivastava, Anurag S.; Li, Ling; Cherney, Robert J.; Gong, Hua; Watterson, Scott H.; Weigelt, Carolyn; Gillooly, Kathleen M.; McIntyre, Kim W.; Xie, Jenny H.; Obermeier, Mary T.; Fura, Aberra; Sleczka, Bogdan; Stefanski, Kevin; Fancher, R. M.; Padmanabhan, Shweta; Thatipamula, R. P.; Kundu, Ipsit; Rajareddy, Kallem; Smith, Rodney; Herman, James K.; Xing, Dezhi; Fan, Jingsong; Levesque, Paul C.; Ruan, Qian; Pitt, Sidney; Zhang, Rosemary; Pedicord, Donna; Pan, Jie; Yarde, Melissa; Lu, Hao; Lippy, Jonathan; Goldstine, Christine; Skala, Stacey; Rampulla, Richard A.; Mathur, Arvind; Gupta, Anuradha; Arunachalam, Pirama Nayagam; Sack, John S.; Muckelbauer, Jodi K.; Cvijic, Mary Ellen; Salter-Cid, Luisa M.; Bhide, Rajeev S.; Poss, Michael A.; Hynes, John; Carter, Percy H.; Macor, John E.; Ruepp, Stefan; Schieven, Gary L.; Tino, Joseph A.

Asymmetric Hydroboration Approach to the Scalable Synthesis of ((1R,3S)-1-Amino-34(R)-6-hexy1-5,6,7,8-tetrahydronaphthalen-2yl)cyclopentyl)methanol (BMS-986104) as a Potent S1P1 Receptor Modulator

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2016-12-0710

PREAI

Yang, Michael G.; Xiao, Zili; Dhar, T. G. Murali; Xiao, Hai-Yun; Gilmore, John L.; Marcoux, David; Xie, Jenny H.; McIntyre, Kim W.; Taylor, Tracy L.; Borowski, Virna; Heimrich, Elizabeth; Li, Yu-Wen; Feng, Jianlin; Fernandes, Alda; Yang, Zheng; Balimane, Praveen; Marino, Anthony M.; Cornelius, Georgia; Warrack, Bethanne M.; Mathur, Arvind; Wu, Dauh-Rurng; Li, Peng; Gupta, Anuradha; Pragalathan, Bala; Shen, Ding Ren; Cvijic, Mary Ellen; Lehman-McKeeman, Lois D.; Salter-Cid, Luisa; Barrish, Joel C.; Carter, Percy H.; Dyckman, Alaric J.

Effect of Counterion Structure on Rates and Diastereoselectivities in α,β-Unsaturated Iminium-Ion Diels-Alder Reactions

ORGANIC LETTERS

IF5

2011-06-1633