未登录 分享 收藏
分享 收藏
分享 收藏
分享 收藏
Discovery of ATP competitive PDHK1/2 dual inhibitors ATP竞争性PDHK1/2双靶点抑制剂的发现 Xu, Hongtao; Ding, Dong; Han, Xingchun; Miao, Kun; Liang, Chungen; Yun, Hongying; Zhu, Wei; Dey, Fabian; Zhao, Dan; Wu, Yao; Reutlinger, Michael; Yang, June; Zhai, Guanglei; Lin, Zhaohu; Li, Chiho; Wu, Waikong; Xu, Bruce; Han, Li; Chen, Shuai; Huang, Xinyi; Casagrande, Fabio; Hilbert, Manuel; Strebel, Quentin; Wichert, Moreno; Westwood, Paul; Schafer, Ramona; Roth, Doris; Heer, Dominik; Tian, Xiaojun; Ma, Tiantian; Zhang, Tong; Zhao, Jie; Urich, Eduard; Xia, Guliang; Lassen, Kara; Shen, Hong C.; Zou, Ge 分享 收藏
Discovery of Naphthyridinone Derivatives as Selective and Potent PKMYT1 Inhibitors with Antitumor Efficacy 作为选择性且高效的PKMYT1抑制剂并具有抗肿瘤活性的萘啶酮衍生物的发现 Chen, Bo; Liu, Xiaofeng; Mu, Tong; Xu, Jiasu; Zhao, Dan; Dey, Fabian; Tang, Yang; Xu, Zhiheng; Yang, June; Huang, Ke; Li, Chiho; Chen, Shuai; Zhu, Sining; Wang, Summer; Yao, Xiangyu; Yan, Zhipeng; Tu, Yifan; Dai, Yu; Qiu, Hongxia; Yang, Juhao; Jiang, Tianyi; Qi, Yunyue; Li, Yi; Shen, Hong C.; Zhu, Wei; Tan, Xuefei; Wu, Jun 分享 收藏
Discovery of 4,5,6,7-Tetrahydropyrazolo[1.5-a]pyrizine Derivatives as Core Protein Allosteric Modulators (CpAMs) for the Inhibition of Hepatitis B Virus Kou, Buyu; Zhang, Zhisen; Han, Xingchun; Zhou, Zheng; Xu, Zhiheng; Zhou, Xue; Shen, Fang; Zhou, Yuan; Tian, Xiaojun; Yang, Guang; Young, John A. T.; Qiu, Hongxia; Ottaviani, Giorgio; Mayweg, Alexander; Zhu, Wei; Shen, Hong C.; Liu, Haixia; Hu, Taishan 分享 收藏
Discovery of Linvencorvir (RG7907), a Hepatitis B Virus Core Protein Allosteric Modulator, for the Treatment of Chronic HBV Infection Zhang, Weixing; Guo, Lei; Liu, Haixia; Wu, Guolong; Shi, Houguang; Zhou, Mingwei; Zhang, Zhisen; Kou, Buyu; Hu, Taishan; Zhou, Zheng; Xu, Zhiheng; Zhou, Xue; Zhou, Yuan; Tian, Xiaojun; Yang, Guang; Young, John A. T.; Qiu, Hongxia; Ottaviani, Giorgio; Xie, Jianxun; Mayweg, Alexander, V; Shen, Hong C.; Zhu, Wei 分享 收藏
分享 收藏
Discovery of Novel cccDNA Reducers toward the Cure of Hepatitis B Virus Infection Chen, Dongdong; Tan, Xuefei; Chen, Wenming; Liu, Yongfu; Li, Chao; Wu, Jun; Zheng, Jiamin; Shen, Hong C.; Zhang, Meifang; Wu, Waikwong; Wang, Lin; Xiong, Jing; Dai, Jieyu; Sun, Kai; Zhang, Jitao David; Xiang, Kunlun; Li, Baocun; Ni, XiaoJu; Zhu, Qihui; Gao, Lu; Wang, Li; Feng, Song 分享 收藏
Discovery of Pyrido[2,3-b]indole Derivatives with Gram-Negative Activity Targeting Both DNA Gyrase and Topoisomerase IV Hu, Yimin; Shi, Houguang; Zhou, Mingwei; Ren, Qingcheng; Zhu, Wei; Zhang, Weixing; Zhang, Zhiwei; Zhou, Chengang; Liu, Yongqiang; Ding, Xiao; Shen, Hong C.; Yan, S. Frank; Dey, Fabian; Wu, Waikwong; Zhai, Guanglei; Zhou, Zheng; Xu, Zhiheng; Ji, Ying; Lv, Hua; Jiang, Tianyi; Wang, Wen; Xu, Yunhua; Vercruysse, Maarten; Yao, Xiangyu; Mao, Yi; Yu, Xiaomin; Bradley, Kenneth; Tan, Xuefei 分享 收藏
Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors Liu, Yongfu; Wu, Jun; Zhou, Mingwei; Chen, Wenming; Li, Dongbo; Wang, Zhanguo; Hornsperger, Benoit .; Aebi, Johannes D.; Marki, Hans-Peter; Kuhn, Bernd; Wang, Lisha; Kuglstatter, Andreas; Benz, Jorg; Muller, Stephan; Hochstrasser, Remo; Ottaviani, Giorgio; Xin, Jian; Kirchner, Stephan; Mohr, Susanne; Verry, Philippe; Riboulet, William; Shen, Hong C.; Mayweg, Alexander V.; Amrein, Kurt; Tan, Xuefei 分享 收藏
Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling Holden, Jeffrey K.; Crawford, James J.; Noland, Cameron L.; Schmidt, Stephen; Zbieg, Jason R.; Lacap, Jennifer A.; Zang, Richard; Miller, Gregory M.; Zhang, Yue; Beroza, Paul; Reja, Rohit; Lee, Wendy; Tom, Jeffrey Y. K.; Fong, Rina; Steffek, Micah; Clausen, Saundra; Hagenbeek, Thjis J.; Hu, Taishan; Zhou, Zheng; Shen, Hong C.; Cunningham, Christian N. 分享 收藏
分享 收藏
A New Approach of Mitigating CYP3A4 Induction Led to the Discovery of Potent Hepatitis B Virus (HBV) Capsid Inhibitor with Optimal ADMET Profiles Lin, Xianfeng; Shi, Houguang; Zhang, Weixing; Qiu, Zongxing; Zhou, Zheng; Dey, Fabian; Zhong, Sheng; Qiu, Hongxia; Xie, Jianxun; Zhou, Xue; Yang, Guang; Tang, Guozhi; Shen, Hong C.; Zhu, Wei 分享 收藏
Discovery of Ziresovir as a Potent, Selective, and Orally Bioavailable Respiratory Syncytial Virus Fusion Protein Inhibitor Zheng, Xiufang; Gao, Lu; Wang, Lisha; Liang, Chungen; Wang, Baoxia; Liu, Yongfu; Feng, Song; Zhang, Bo; Zhou, Mingwei; Yu, Xin; Xiang, Kunlun; Chen, Li; Guo, Tao; Shen, Hong C.; Zou, Gang; Wu, Jim Zhen; Yun, Hongying 分享 收藏
De novo synthesis, structural assignment and biological evaluation of pseudopaline, a metallophore produced by Pseudomonas aeruginosa Zhang, Jian; Zhao, Tianhu; Yang, Rongwen; Siridechakorn, Ittipon; Wang, Sanshan; Guo, Qianqian; Bai, Yingjie; Shen, Hong C.; Lei, Xiaoguang 分享 收藏
Discovery of Benzoazepinequinoline (BAQ) Derivatives as Novel, Potent, Orally Bioavailable Respiratory Syncytial Virus Fusion Inhibitors Zheng, Xiufang; Liang, Chungen; Wang, Lisha; Wang, Baoxia; Liu, Yongfu; Feng, Song; Wu, Jim Zhen; Gao, Lu; Feng, Lichun; Chen, Li; Guo, Tao; Shen, Hong C.; Yun, Hongying 分享 收藏
Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action Han, Xingchun; Zhou, Chengang; Jiang, Min; Wang, Yongguang; Wang, Jianhua; Cheng, Zhanling; Wang, Min; Liu, Yongqiang; Liang, Chungen; Wang, Jianping; Wang, Zhanguo; Weikert, Robert; Lv, Wenzhe; Xie, Jianxun; Yu, Xin; Zhou, Xue; Luangsay, Souphalone; Shen, Hong C.; Mayweg, Alexander V.; Javanbakht, Hassan; Yang, Song 分享 收藏
Potassium Iodide-Promoted One-Pot Synthesis of Fluoroalkylated Quinoxalines via a Tandem Michael Addition/Azidation/Cycloamination Approach Wu, Jun; Zhang, Hui; Ding, Xiao; Tan, Xuefei; Chen, Jie; He, Weimin; Deng, Hongmei; Song, Liping; Shen, Hong C.; Cao, Weiguo 分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
