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Structure-Guided Design of Potent Coronavirus Inhibitors with a 2-Pyrrolidone Scaffold: Biochemical, Crystallographic, and Virological Studies Dampalla, Chamandi S.; Kim, Yunjeong; Zabiegala, Alexandria; Howard, Dennis J.; Nguyen, Harry Nhat; Madden, Trent K.; Thurman, Hayden A.; Cooper, Anne; Liu, Lijun; Battaile, Kevin P.; Lovell, Scott; Chang, Kyeong-Ok; Groutas, William C. 分享 收藏
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Potent 3CLpro inhibitors effective against SARS-CoV-2 and MERS-CoV in animal models by therapeutic treatment Li, Pengfei; Kim, Yunjeong; Dampalla, Chamandi S.; Nhat Nguyen, Harry; Meyerholz, David K.; Johnson, David K.; Lovell, Scott; Groutas, William C.; Perlman, Stanley; Chang, Kyeong-Ok 分享 收藏
The smallest functional antibody fragment: Ultralong CDR H3 antibody knob regions potently neutralize SARS-CoV-2 Huang, Ruiqi; Jenkins, Gabrielle Warner; Kim, Yunjeong; Stanfield, Robyn L.; Singh, Amrinder; Martinez-Yamout, Maria; Kroon, Gerard J.; Torres, Jonathan L.; Jackson, Abigail M.; Kelley, Abigail; Shaabani, Namir; Zeng, Baisen; Bacica, Michael; Chen, Wen; Warner, Christopher; Radoicic, Jasmina; Joh, Joongho; Perera, Krishani Dinali; Sang, Huldah; Kim, Tae; Yao, Jianxiu; Zhao, Fangzhu; Sokd, Devin; Burton, Dennis R.; Allen, Jeff; Harriman, William; Mwangi, Waithaka; Chung, Donghoon; Teijaro, John R.; Ward, Andrew B.; Dyson, H. Jane; Wright, Peter E.; Wilson, Ian A.; Chang, Kyeong-Ok; Mcgregor, Duncan; Smider, Vaughn V. 分享 收藏
Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and middle east respiratory syndrome coronavirus (MERS-CoV) Dampalla, Chamandi S.; Miller, Matthew J.; Kim, Yunjeong; Zabiegala, Alexandria; Nguyen, Harry Nhat; Madden, Trent K.; Thurman, Hayden A.; Machen, Alexandra J.; Cooper, Anne; Liu, Lijun; Battaile, Kevin P.; Lovell, Scott; Chang, Kyeong-Ok; Groutas, William C. 分享 收藏
SARS-CoV-2 Omicron (B.1.1.529) Infection of Wild White-Tailed Deer in New York City 纽约市野生白尾鹿的SARS-CoV-2 Omicron (B.1.1.529) 感染 Vandegrift, Kurt J.; Yon, Michele; Surendran Nair, Meera; Gontu, Abhinay; Ramasamy, Santhamani; Amirthalingam, Saranya; Neerukonda, Sabarinath; Nissly, Ruth H.; Chothe, Shubhada K.; Jakka, Padmaja; LaBella, Lindsey; Levine, Nicole; Rodriguez, Sophie; Chen, Chen; Sheersh Boorla, Veda; Stuber, Tod; Boulanger, Jason R.; Kotschwar, Nathan; Aucoin, Sarah Grimke; Simon, Richard; Toal, Katrina L.; Olsen, Randall J.; Davis, James J.; Bold, Dashzeveg; Gaudreault, Natasha N.; Dinali Perera, Krishani; Kim, Yunjeong; Chang, Kyeong-Ok; Maranas, Costas D.; Richt, Juergen A.; Musser, James M.; Hudson, Peter J.; Kapur, Vivek; Kuchipudi, Suresh V. 分享 收藏
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Effects of Spike Mutations in SARS-CoV-2 Variants of Concern on Human or Animal ACE2-Mediated Virus Entry and Neutralization Kim, Yunjeong; Gaudreault, Natasha N.; Meekins, David A.; Perera, Krishani D.; Bold, Dashzeveg; Trujillo, Jessie D.; Morozov, Igor; McDowell, Chester D.; Chang, Kyeong-Ok; Richt, Juergen A. 分享 收藏
Structure-Guided Design of Potent Spirocyclic Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3C-like Protease Dampalla, Chamandi S.; Rathnayake, Athri D.; Kankanamalage, Anushka C. Galasiti; Kim, Yunjeong; Perera, Krishani Dinali; Nguyen, Harry Nhat; Miller, Matthew J.; Madden, Trent K.; Picard, Hunter R.; Thurman, Hayden A.; Kashipathy, Maithri M.; Liu, Lijun; Battaile, Kevin P.; Lovell, Scott; Chang, Kyeong-Ok; Groutas, William C. 分享 收藏
Structure-Guided Design of Potent Inhibitors of SARS-CoV-2 3CL Protease: Structural, Biochemical, and Cell-Based Studies Dampalla, Chamandi S.; Rathnayake, Athri D.; Perera, Krishani Dinali; Jesri, Abdul-Rahman M.; Nguyen, Harry Nhat; Miller, Matthew J.; Thurman, Hayden A.; Zheng, Jian; Kashipathy, Maithri M.; Battaile, Kevin P.; Lovell, Scott; Perlman, Stanley; Kim, Yunjeong; Groutas, William C.; Chang, Kyeong-Ok 分享 收藏
Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3CL Protease Dampalla, Chamandi S.; Kim, Yunjeong; Bickmeier, Naemi; Rathnayake, Athri D.; Nguyen, Harry Nhat; Zheng, Jian; Kashipathy, Maithri M.; Baird, Matthew A.; Battaile, Kevin P.; Lovell, Scott; Perlman, Stanley; Chang, Kyeong-Ok; Groutas, William C. 分享 收藏
Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection 用蛋白酶抑制剂进行感染后治疗可提高致死性SARS-CoV-2感染小鼠的存活率 Dampalla, Chamandi S.; Zheng, Jian; Perera, Krishani Dinali; Wong, Lok-Yin Roy; Meyerholz, David K.; Nguyen, Harry Nhat; Kashipathy, Maithri M.; Battaile, Kevin P.; Lovell, Scott; Kim, Yunjeong; Perlman, Stanley; Groutas, William C.; Chang, Kyeong-Ok 分享 收藏
Structure-Guided Optimization of Dipeptidyl Inhibitors of Norovirus 3CL Protease Rathnayake, Athri D.; Kim, Yunjeong; Dampalla, Chamandi S.; Nguyen, Harry Nhat; Jesri, Abdul-Rahman M.; Kashipathy, Maithri M.; Lushington, Gerald H.; Battaile, Kevin P.; Lovell, Scott; Chang, Kyeong-Ok; Groutas, William C. 分享 收藏
3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice Rathnayake, Athri D.; Zheng, Jian; Kim, Yunjeong; Perera, Krishani Dinali; Mackin, Samantha; Meyerholz, David K.; Kashipathy, Maithri M.; Battaile, Kevin P.; Lovell, Scott; Perlman, Stanley; Groutas, William C.; Chang, Kyeong-Ok 分享 收藏
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Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element Kankanamalage, Anushka C. Galasiti; Kim, Yunjeong; Damalanka, Vishnu C.; Rathnayake, Athri D.; Fehr, Anthony R.; Mehzabeen, Nurjahan; Battaile, Kevin P.; Lovell, Scott; Lushington, Gerald H.; Perlman, Stanley; Chang, Kyeong-Ok; Groutas, William C. 分享 收藏
Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease Damalanka, Vishnu C.; Kim, Yunjeong; Kankanamalage, Anushka C. Galasiti; Rathnayake, Athri D.; Mehzabeen, Nurjahan; Battaile, Kevin P.; Lovell, Scott; Harry Nhat Nguyen; Lushington, Gerald H.; Chang, Kyeong-Ok; Groutas, William C. 分享 收藏
Design, Synthesis, and Evaluation of Novel Prodrugs of Transition State Inhibitors of Norovirus 3CL Protease Kankanamalage, Anushka C. Galasiti; Kim, Yunjeong; Rathnayake, Athri D.; Alliston, Kevin R.; Butler, Michelle M.; Cardinale, Steven C.; Bowlin, Terry L.; Groutas, William C.; Chang, Kyeong-Ok 分享 收藏
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