logo
科言猫学术研究的AI总结
language
手机端手机端
  • Phone Feature微信小程序
简体中文简体中文
notice消息通知
博客博客
delete
arrow
返回
J

Jayakumar R. Nair

National Cancer Institute

22H指数
122论文数
1.8K被引数
收录论文 30
发表时间
logo
Durvalumab and cediranib with and without olaparib in recurrent ovarian cancer: a phase II proof-of-concept studyDurvalumab和cediranib联合或不联合olaparib治疗复发性卵巢癌：一项II期概念验证研究
errNature Communications
IF15.7
err2026-03-16
err0
errOAAI
errJunya Tabata; Tzu-Ting Huang; Elena Giudice; Kristen R. Ibanez; Jayakumar R. Nair; Aanika Balaji Warner; Britanny B. Solarz; Valentina Bolanos; Bernadette Redd; Nahoko Sato; Shraddha Rastogi; Sunmin Lee; Roshan L. Shrestha; Alexander Y. Mitrophanov; Stanley Lipkowitz; Kevin Conlon; Chien Chu Huang; Jung-Min Lee
err分享
err收藏
A Phase II Pilot Study of Anti-PD-L1, Durvalumab, and a PARP Inhibitor, Olaparib in Patients With Metastatic Triple-Negative Breast Cancer With or Without Germline BRCA Mutation一项关于抗PD-L1药物Durvalumab和PARP抑制剂Olaparib在携带或不携带胚系BRCA突变的转移性三阴性乳腺癌患者中的II期探索性研究
errCANCER MEDICINE
IF3.1
err2025-12-08
err0
errOAAI
errFujii, Takeo; Cimino-mathews, Ashley; Lipkowitz, Stanley; Lee, Min-Jung; Nair, Jayakumar; Solarz, Britanny Brooke; Zimmer, Alexandra; Redd, Bernadette; Levy, Elliot B.; Rastogi, Shraddha; Sato, Nahoko; McCoy, Ann; Steinberg, Seth M.; Lee, Jung-Min
err分享
err收藏
Poly (ADP-Ribose) Polymerase Inhibitor Olaparib-Resistant BRCA1-Mutant Ovarian Cancer Cells Demonstrate Differential Sensitivity to PARP Inhibitor Rechallenge聚 (ADP-核糖) 聚合酶抑制剂Olaparib耐药的BRCA1-Mutant卵巢癌细胞对PARP抑制剂再攻击表现出不同的敏感性
errCELLS
IF5.2
err2024-11-07
err0
errOAAI
errShih, Chi-Ting; Huang, Tzu-Ting; Nair, Jayakumar R.; Ibanez, Kristen R.; Lee, Jung-Min
err分享
err收藏
The CHK1 inhibitor prexasertib in BRCA wild-type platinum-resistant recurrent high-grade serous ovarian carcinoma: a phase 2 trial
errNATURE COMMUNICATIONS
IF15.7
err2024-03-30
err8
errOAAI
errGiudice, Elena; Huang, Tzu-Ting; Nair, Jayakumar R.; Zurcher, Grant; Mccoy, Ann; Nousome, Darryl; Radke, Marc R.; Swisher, Elizabeth M.; Lipkowitz, Stanley; Ibanez, Kristen; Donohue, Duncan; Malys, Tyler; Lee, Min-Jung; Redd, Bernadette; Levy, Elliot; Rastogi, Shraddha; Sato, Nahoko; Trepel, Jane B.; Lee, Jung-Min
err分享
err收藏
PARP inhibitor (PARPi) rechallenge shows differential sensitivity in PARPi olaparibresistant BRCA1-mutated (BRCA1m) high-grade serous ovarian cancer (HGSC)
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errShih, Chi-Ting; Huang, Tzu-Ting; Nair, Jayakumar R.; Lee, Jung-Min
err分享
err收藏
Combination of ATR inhibitor (ATRi) and AKT inhibitor (AKTi) reduces tumor growth and prolongs survival in BRCA2 mutant (BRCA2m) PARP inhibitor (PARPi)resistant high-grade serous ovarian cancer (HGSC)
errCANCER RESEARCH
IF16.6
err2024-03-04
err0
PREAI
errHuang, Tzu-Ting; Nair, Jayakumar R.; Shih, Chi-Ting; Lee, Jung-Min
err分享
err收藏
AKT1 interacts with DHX9 to Mitigate R Loop-Induced Replication Stress in Ovarian Cancer
errCANCER RESEARCH
IF16.6
err2024-01-19
err4
PREAI
errHuang, Tzu-Ting; Chiang, Chih-Yuan; Nair, Jayakumar R.; Wilson, Kelli M.; Cheng, Ken; Lee, Jung-Min
err分享
err收藏
Validation of the OncoSignature assay, an ACR-368-tailored response-predictive quantitative multiplexed immunofluorescent assay for prediction of sensitivity to the CHK1/2 inhibitor ACR-368 in individual patients with cancer
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2023-12-01
err0
PREAI
errMurshid, Ayesha; Noe, Christina; Singh, Kailash; Choudhury, Sibgat; Nair, Jayakumar; Dunyak, James; Shipitsin, Michail; Lee, Jung-Min; Blume-Jensen, Peter
err分享
err收藏
BLM overexpression as a predictive biomarker for CHK1 inhibitor response in PARP inhibitor-resistant BRCAmutant ovarian cancer
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2023-06-21
err12
errOAAI
errGupta, Nitasha; Huang, Tzu-Ting; Nair, Jayakumar. R. R.; An, Daniel; Zurcher, Grant; Lampert, Erika. J. J.; McCoy, Ann; Cimino-Mathews, Ashley; Swisher, Elizabeth. M. M.; Radke, Marc. R. R.; Lockwood, Christina. M. M.; Reichel, Jonathan. B. B.; Chiang, Chih-Yuan; Wilson, Kelli. M. M.; Cheng, Ken Chih-Chien; Nousome, Darryl; Lee, Jung-Min
err分享
err收藏
AKT1 prevents aberrant R-loops accumulation via regulating DHX9 and suppresses transcription-replication collision in PARP inhibitor-resistant ovarian cancer
errCANCER RESEARCH
IF16.6
err2023-04-04
err0
PREAI
errHuang, Tzu-Ting; Chiang, Chih-Yuan; Nair, Jayakumar R.; Shih, Chi-Ting; Wilson, Kelli; Cheng, Ken Chih-Chien; Lee, Jung-Min
err分享
err收藏
Correlative biomarker analysis of the phase II study of prexasertib, a cell cycle checkpoint kinase 1 (CHK1) inhibitor, in BRCA wild-type (BRCAwt), platinum-resistant recurrent, high-grade serous ovarian cancer (PR-HGSOC)
errCANCER RESEARCH
IF16.6
err2023-04-04
err0
PREAI
errGiudice, Elena; Zurcher, Grant; Nair, Jayakumar; Huang, Tzu-Ting; Lee, Min-Jung; Trepel, Jane B.; Lee, Jung-Min
err分享
err收藏
Distinct roles of treatment schemes and BRCA2 on the restoration of homologous recombination DNA repair and PARP inhibitor resistance in ovarian cancer
errONCOGENE
IF7.3
err2022-10-12
err6
errOAAI
errHuang, Tzu-Ting; Burkett, Sandra Sczerba; Tandon, Mayank; Yamamoto, Tomomi M.; Gupta, Nitasha; Bitler, Benjamin G.; Lee, Jung-Min; Nair, Jayakumar R.
err分享
err收藏
Different treatment schemes cause distinct PARP inhibitor resistance mechanisms in BRCA2-mutant ovarian cancer cells
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2021-12-01
err0
PREAI
errHuang, Tzu-Ting; Nair, Jayakumar R.; Gupta, Nitasha; Yamamoto, Tomomi M.; Bitler, Benjamin G.; Lee, Jung-Min
err分享
err收藏
Targeting the PI3K/mTOR Pathway Augments CHK1 Inhibitor-Induced Replication Stress and Antitumor Activity in High-Grade Serous Ovarian Cancer
errCANCER RESEARCH
IF16.6
err2020-12-02
err20
errOAAI
errHuang, Tzu-Ting; Brill, Ethan; Nair, Jayakumar R.; Zhang, Xiaohu; Wilson, Kelli M.; Chen, Lu; Thomas, Craig J.; Lee, Jung-Min
err分享
err收藏
Combined inhibition of checkpoint kinase 1 (CHK1) and phosphoinositide 3-kinase (PI3K) pathways induces greater replication stress and DNA damage in high-grade serous ovarian cancer (HGSOC)
errCANCER RESEARCH
IF16.6
err2020-08-15
err0
PREAI
errHuang, Tzu-Ting; Nair, Jayakumar; Brill, Ethan; Zhang, Xiaohu; Wilson, Kelli; Chen, Lu; Thomas, Craig J.; Lee, Jung-Min
err分享
err收藏
Resistance to the CHK1 inhibitor prexasertib involves functionally distinct CHK1 activities in BRCA wild-type ovarian cancer
errONCOGENE
IF7.3
err2020-07-09
err30
errOAAI
errNair, Jayakumar; Huang, Tzu-Ting; Murai, Junko; Haynes, Brittany; Steeg, Patricia S.; Pommier, Yves; Lee, Jung-Min
err分享
err收藏
Cell cycle checkpoint kinase (CHK)1 inhibition induces immune modulation in recurrent BRCA wild-type high-grade serous ovarian cancer (HGSOC) patients
errCANCER RESEARCH
IF16.6
err2019-07-01
err0
PREAI
errLampert, Erika J.; Lee, Min-Jung; Trepel, Jane B.; Yuno, Akira; Cimino-Mathews, Ashley; Lee, Joo-Sang; Ruppin, Eytan; Nair, Jayakumar; Ekwede, Irene; Lee, Jung-Min
err分享
err收藏
Evaluating HDAC6 as a causal factor in metastatic breast cancer to develop immunotherapy
errCANCER RESEARCH
IF16.6
err2017-07-01
err1
PREAI
errBanik, Debarati; Hadley, Melissa; Kim, Jennifer; Knox, Tessa; Nair, Jayakumar; Kozikowski, Alan; Shen, Sida; Vyas, Charu; Donohue, Ashleyn; Sotomayor, Eduardo; Villagra, Alejandro
err分享
err收藏
A novel regulatory role of HDAC6 in the functional inflammatory phenotype of glia cells
errCANCER RESEARCH
IF16.6
err2017-07-01
err1
PREAI
errKim, Jennifer; Nair, Jayakumar R.; Hadley, Melissa M.; Kozikowski, Alan; Miller, Robert; Villagra, Alejandro
err分享
err收藏
In vivo evaluation of Ames negative HDAC6 inhibitor in melanoma model
errCANCER RESEARCH
IF16.6
err2017-07-01
err0
PREAI
errHadley, Melissa; Shen, Sida; Banik, Debarati; Kim, Jennifer; Nair, Jayakumar; Knox, Tessa; Gallub, Vincent; Kirkland, Shannon; Chiappinelli, Katherine B.; Sotomayor, Eduardo; Kozikowski, Alan; Villagra, Alejandro
err分享
err收藏

研究方向

暂时未获取到该数据
合作学者
合作期刊
S
Seth M. Steinberg
H 指数: 148 · 论文数: 1.6K
J
J. Jack Lee
H 指数: 146 · 论文数: 2.8K

Yves Pommier
H 指数: 138 · 论文数: 2.0K
C
Curtis C. Harris
H 指数: 137 · 论文数: 1.3K
J
Jeffrey S. Weber
H 指数: 122 · 论文数: 1.2K
查看更多