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Lyndsey Hanson

AstraZeneca
H指数:12
被引数:802

个人简介

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荣誉奖项

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Bcl-xL Is a Key Mediator of Apoptosis Following KRASG12C Inhibition in KRASG12C-mutant Colorectal Cancer
MOLECULAR CANCER THERAPEUTICS
IF5.5
2022-10-225
OAAI
Khawaja, Hajrah; Briggs, Rebecca; Latimer, Cheryl H.; Rassel, Mustasin; Griffin, Dary; Hanson, Lyndsey; Bardelli, Alberto; Di Nicolantonio, Frederica; McDade, Simon S.; Scott, Christopher J.; Lambe, Shauna; Maurya, Manisha; Lindner, Andreas U.; Prehn, Jochen H. M.; Sousa, Jose; Winnington, Chris; LaBonte, Melissa J.; Ross, Sarah; Van Schaeybroeck, Sandra
AZD4625 is a Potent and Selective Inhibitor of KRASG12C
MOLECULAR CANCER THERAPEUTICS
IF5.5
2022-08-052
OAAI
Chakraborty, Atanu; Hanson, Lyndsey; Robinson, David; Lewis, Hilary; Bickerton, Sue; Davies, Michael; Polanski, Radoslaw; Whiteley, Rebecca; Koers, Alex; Atkinson, James; Baker, Tamara; Barrantes, Ivan del Barco; Ciotta, Giovanni; Kettle, Jason G.; Magiera, Lukasz; Martins, Carla P.; Peter, Alison; Wigmore, Eleanor; Underwood, Zoe; Cosulich, Sabina; Niedbala, Michael; Ross, Sarah
Discovery of AZD4625, a Covalent Allosteric Inhibitor of the MutantGTPase KRASG12C

突变gtpase KRASG12C的共价变构抑制剂AZD4625的发现

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-04-2637
PRE
Kettle, Jason G.; Bagal, Sharan K.; Bickerton, Sue; Bodnarchuk, Michael S.; Boyd, Scott; Breed, Jason; Carbajo, Rodrigo J.; Cassar, Doyle J.; Chakraborty, Atanu; Cosulich, Sabina; Cumming, Iain; Davies, Michael; Davies, Nichola L.; Eatherton, Andrew; Evans, Laura; Feron, Lyman; Fillery, Shaun; Gleave, Emma S.; Goldberg, Frederick W.; Hanson, Lyndsey; Harlfinger, Stephanie; Howard, Martin; Howells, Rachel; Jackson, Anne; Kemmitt, Paul; Lamont, Gillian; Lamont, Scott; Lewis, Hilary J.; Liu, Libin; Niedbala, Michael J.; Phillips, Christopher; Polanski, Radek; Raubo, Piotr; Robb, Graeme; Robinson, David M.; Ross, Sarah; Sanders, Matthew G.; Tonge, Michael; Whiteley, Rebecca; Wilkinson, Stephen; Yang, Junsheng; Zhang, Wenman
AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib
MOLECULAR CANCER THERAPEUTICS
IF5.5
2021-02-0516
OAAI
Flemington, Vikki; Davies, Emma J.; Robinson, David; Sandin, Linda C.; Delpuech, Oona; Zhang, Pei; Hanson, Lyndsey; Farrington, Paul; Bell, Sigourney; Falenta, Katarzyna; Gibbons, Francis D.; Lindsay, Nicola; Smith, Aaron; Wilson, Joanne; Roberts, Karen; Tonge, Michael; Hopcroft, Philip; Willis, Sophie E.; Roudier, Martine P.; Rooney, Claire; Coker, Elizabeth A.; Jaaks, Patricia; Garnett, Mathew J.; Fawell, Stephen E.; Jones, Clifford D.; Ward, Richard A.; Simpson, Iain; Cosulich, Sabina C.; Pease, J. Elizabeth; Smith, Paul D.
Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-02-0560
PREAI
Kettle, Jason G.; Bagal, Sharan K.; Bickerton, Sue; Bodnarchuk, Michael S.; Breed, Jason; Carbajo, Rodrigo J.; Cassar, Doyle J.; Chakraborty, Atanu; Cosulich, Sabina; Cumming, Iain; Davies, Michael; Eatherton, Andrew; Evans, Laura; Feron, Lyman; Fillery, Shaun; Gleave, Emma S.; Goldberg, Frederick W.; Harlfinger, Stephanie; Hanson, Lyndsey; Howard, Martin; Howells, Rachel; Jackson, Anne; Kemmitt, Paul; Kingston, Jennifer K.; Lamont, Scott; Lewis, Hilary J.; Li, Songlei; Liu, Libin; Ogg, Derek; Phillips, Christopher; Polanski, Radek; Robb, Graeme; Robinson, David; Ross, Sarah; Smith, James M.; Tonge, Michael; Whiteley, Rebecca; Yang, Junsheng; Zhang, Longfei; Zhao, Xiliang
Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-11-1150
PREAI
Ward, Richard A.; Anderton, Mark J.; Bethel, Paul; Breed, Jason; Cook, Calum; Davies, Emma J.; Dobson, Andrew; Dong, Zhiqiang; Fairley, Gary; Farrington, Paul; Feron, Lyman; Flemington, Vikki; Gibbons, Francis D.; Graham, Mark A.; Greenwood, Ryan; Hanson, Lyndsey; Hopcroft, Philip; Howells, Rachel; Hudson, Julian; James, Michael; Jones, Clifford D.; Jones, Christopher R.; Li, Yongchao; Lamont, Scott; Lewis, Richard; Lindsay, Nicola; McCabe, James; McGuire, Thomas; Rawlins, Philip; Roberts, Karen; Sandin, Linda; Simpson, Iain; Swallow, Steve; Tang, Jia; Tomkinson, Gary; Tonge, Michael; Wang, Zhenhua; Zhai, Baochang
Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2017-04-1443
PREAI
Ward, Richard A.; Bethel, Paul; Cook, Calum; Davies, Emma; Debreczeni, Judit E.; Fairley, Gary; Feron, Lyman; Flemington, Vikki; Graham, Mark A.; Greenwood, Ryan; Griffin, Nicola; Hanson, Lyndsey; Hoperoft, Philip; Howard, Tina D.; Liudson, Julian; James, Michael; Jones, Clifford D.; Jones, Christopher R.; Lamont, Scott; Lewis, Richard; Lindsay, Nicola; Roberts, Karen; Simpson, Iain; St-Gallay, Steve; Swallow, Steve; Tang, Jia; Tonge, Michael; Wang, Zhenhua; Zhai, Baochang
Intermittent High-Dose Scheduling of AZD8835, a Novel Selective Inhibitor of PI3Kα and PI3Kδ, Demonstrates Treatment Strategies for PIK3CA-Dependent Breast Cancers
MOLECULAR CANCER THERAPEUTICS
IF5.5
2016-05-0537
OAAI
Hudson, Kevin; Hancox, Urs J.; Trigwell, Cath; McEwen, Robert; Polanska, Urszula M.; Nikolaou, Myria; Gutierrez, Pablo Morentin; Avivar-Valderas, Alvaro; Delpuech, Oona; Dudley, Phillippa; Hanson, Lyndsey; Ellston, Rebecca; Jones, Alys; Cumberbatch, Marie; Cosulich, Sabina C.; Ward, Lara; Cruzalegui, Francisco; Green, Stephen
Inhibition of PI3Kβ Signaling with AZD8186 Inhibits Growth of PTEN-Deficient Breast and Prostate Tumors Alone and in Combination with Docetaxel
MOLECULAR CANCER THERAPEUTICS
IF5.5
2015-01-1373
OAAI
Hancox, Urs; Cosulich, Sabina; Hanson, Lyndsey; Trigwell, Cath; Lenaghan, Carol; Ellston, Rebecca; Dry, Hannah; Crafter, Claire; Barlaam, Bernard; Fitzek, Martina; Smith, Paul D.; Ogilvie, Donald; D'Cruz, Celina; Castriotta, Lillian; Wedge, Stephen R.; Ward, Lara; Powell, Steve; Lawson, Mandy; Davies, Barry R.; Harrington, Elizabeth A.; Foster, Emily; Cumberbatch, Marie; Green, Stephen; Barry, Simon T.

研究方向

暂未获取到该数据
S
Sarah J. Ross
H 指数:28论文数:163被引数:5,973
S
Sabina Cosulich
H 指数:36论文数:293被引数:5,862
R
Rebecca Ellston
H 指数:14论文数:91被引数:3,011
M
Michael Tonge
H 指数:12论文数:68被引数:958
R
Rebecca Whiteley
H 指数:5论文数:28被引数:179
D
David M. Robinson
H 指数:21论文数:86被引数:1,820
E
Emma Jane Davies
H 指数:26论文数:181被引数:3,822
V
Vikki Flemington
H 指数:10论文数:63被引数:915
U
Urs J. Hancox
H 指数:10论文数:86被引数:678
N
Nicola Lindsay
H 指数:10论文数:64被引数:410