logo
科言猫学术研究的AI总结
language
手机端手机端
  • Phone Feature微信小程序
简体中文简体中文
notice消息通知
博客博客
arrow
D

David M. Robinson

AstraZeneca
H指数:21
被引数:1,820

个人简介

暂无内容

教育背景

暂无内容

工作经历

暂无内容

荣誉奖项

暂无内容

AZD4625 is a Potent and Selective Inhibitor of KRASG12C
MOLECULAR CANCER THERAPEUTICS
IF5.5
2022-08-052
OAAI
Chakraborty, Atanu; Hanson, Lyndsey; Robinson, David; Lewis, Hilary; Bickerton, Sue; Davies, Michael; Polanski, Radoslaw; Whiteley, Rebecca; Koers, Alex; Atkinson, James; Baker, Tamara; Barrantes, Ivan del Barco; Ciotta, Giovanni; Kettle, Jason G.; Magiera, Lukasz; Martins, Carla P.; Peter, Alison; Wigmore, Eleanor; Underwood, Zoe; Cosulich, Sabina; Niedbala, Michael; Ross, Sarah
Discovery of AZD4625, a Covalent Allosteric Inhibitor of the MutantGTPase KRASG12C

突变gtpase KRASG12C的共价变构抑制剂AZD4625的发现

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-04-2637
PRE
Kettle, Jason G.; Bagal, Sharan K.; Bickerton, Sue; Bodnarchuk, Michael S.; Boyd, Scott; Breed, Jason; Carbajo, Rodrigo J.; Cassar, Doyle J.; Chakraborty, Atanu; Cosulich, Sabina; Cumming, Iain; Davies, Michael; Davies, Nichola L.; Eatherton, Andrew; Evans, Laura; Feron, Lyman; Fillery, Shaun; Gleave, Emma S.; Goldberg, Frederick W.; Hanson, Lyndsey; Harlfinger, Stephanie; Howard, Martin; Howells, Rachel; Jackson, Anne; Kemmitt, Paul; Lamont, Gillian; Lamont, Scott; Lewis, Hilary J.; Liu, Libin; Niedbala, Michael J.; Phillips, Christopher; Polanski, Radek; Raubo, Piotr; Robb, Graeme; Robinson, David M.; Ross, Sarah; Sanders, Matthew G.; Tonge, Michael; Whiteley, Rebecca; Wilkinson, Stephen; Yang, Junsheng; Zhang, Wenman
AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib
MOLECULAR CANCER THERAPEUTICS
IF5.5
2021-02-0516
OAAI
Flemington, Vikki; Davies, Emma J.; Robinson, David; Sandin, Linda C.; Delpuech, Oona; Zhang, Pei; Hanson, Lyndsey; Farrington, Paul; Bell, Sigourney; Falenta, Katarzyna; Gibbons, Francis D.; Lindsay, Nicola; Smith, Aaron; Wilson, Joanne; Roberts, Karen; Tonge, Michael; Hopcroft, Philip; Willis, Sophie E.; Roudier, Martine P.; Rooney, Claire; Coker, Elizabeth A.; Jaaks, Patricia; Garnett, Mathew J.; Fawell, Stephen E.; Jones, Clifford D.; Ward, Richard A.; Simpson, Iain; Cosulich, Sabina C.; Pease, J. Elizabeth; Smith, Paul D.
Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
2020-05-1552
OAAI
McAulay, Kirsten; Hoyt, Emily A.; Thomas, Morgan; Schimpl, Marianne; Bodnarchuk, Michael S.; Lewis, Hilary J.; Barratt, Derek; Bhavsar, Deepa; Robinson, David M.; Deery, Michael J.; Ogg, Derek J.; Bernardes, Goncalo J. L.; Ward, Richard A.; Waring, Michael J.; Kettle, Jason G.
Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-02-0560
PREAI
Kettle, Jason G.; Bagal, Sharan K.; Bickerton, Sue; Bodnarchuk, Michael S.; Breed, Jason; Carbajo, Rodrigo J.; Cassar, Doyle J.; Chakraborty, Atanu; Cosulich, Sabina; Cumming, Iain; Davies, Michael; Eatherton, Andrew; Evans, Laura; Feron, Lyman; Fillery, Shaun; Gleave, Emma S.; Goldberg, Frederick W.; Harlfinger, Stephanie; Hanson, Lyndsey; Howard, Martin; Howells, Rachel; Jackson, Anne; Kemmitt, Paul; Kingston, Jennifer K.; Lamont, Scott; Lewis, Hilary J.; Li, Songlei; Liu, Libin; Ogg, Derek; Phillips, Christopher; Polanski, Radek; Robb, Graeme; Robinson, David; Ross, Sarah; Smith, James M.; Tonge, Michael; Whiteley, Rebecca; Yang, Junsheng; Zhang, Longfei; Zhao, Xiliang
AZD3514: A Small Molecule That Modulates Androgen Receptor Signaling and Function In Vitro and In Vivo
MOLECULAR CANCER THERAPEUTICS
IF5.5
2013-09-0575
OAAI
Loddick, Sarah A.; Ross, Sarah J.; Thomason, Andrew G.; Robinson, David M.; Walker, Graeme E.; Dunkley, Tom P. J.; Brave, Sandra R.; Broadbent, Nicola; Stratton, Natalie C.; Trueman, Dawn; Mouchet, Elizabeth; Shaheen, Fadhel S.; Jacobs, Vivien N.; Cumberbatch, Marie; Wilson, Joanne; Jones, Rhys D. O.; Bradbury, Robert H.; Rabow, Alfred; Gaughan, Luke; Womack, Chris; Barry, Simon T.; Robson, Craig N.; Critchlow, Susan E.; Wedge, Stephen R.; Brooks, A. Nigel
Preclinical profile of AZD3514: A small molecule-targeting androgen receptor function with a novel mechanism of action and the potential to treat castration-resistant prostate cancer
CANCER RESEARCH
IF16.6
2012-04-013
PRE
Loddick, Sarah A.; Bradbury, Rob; Broadbent, Nicola; Campbell, Hayley; Gaughan, Luke; Growcott, Jim; Stratton, Natalie; Mouchet, Elizabeth; O'Neill, Daniel; Rabow, Al; Robinson, David; Robson, Craig N.; Ross, Sarah J.; Shaheen, Fadhel; Trueman, Dawn; Walker, Graeme; Wedge, Stephen R.; Brooks, Nigel A. N.

研究方向

暂未获取到该数据
L
Lyndsey Hanson
H 指数:12论文数:130被引数:802
S
Sarah J. Ross
H 指数:28论文数:163被引数:5,970
H
Hilary Lewis
H 指数:14论文数:63被引数:1,234
J
Jason G. Kettle
H 指数:31论文数:163被引数:3,405
R
Richard A. Ward
H 指数:51论文数:308被引数:1.1万
S
Sabina Cosulich
H 指数:36论文数:293被引数:5,859
M
Michael Tonge
H 指数:12论文数:68被引数:957
R
Rebecca Whiteley
H 指数:5论文数:28被引数:179
M
Michael S. Bodnarchuk
H 指数:16论文数:40被引数:1,018
J
J. Breed
H 指数:40论文数:108被引数:4,797