Meredith E. Jackrel - Publications, H-index & Citations

Meredith E. Jackrel

washington university

25H指数

71论文数

2.5K被引数

收录论文 29

发表时间

High-throughput screening approach identifies substrate-selective Hsp104 variants that counter amyloid seeding with diminished off-target effects 高通量筛选方法鉴定出能对抗淀粉样蛋白种籽并减少脱靶效应的底物选择性Hsp104变体

Molecular Cell

IF16.6

2026-05-12

OAAI

Jeremy J. Ryan; Karlie R. Miller; Anuradhika Puri; Macy L. Sprunger; Madalyn M. Bochantine; April Lopez; Sheng Chen; Aaron Bao; Cendi Ling; Andy Xu; Braxton Bell; Brian S. Sohn; Leo Li; Cynthia Chang; Kalid Mohammed; Max V. Staller; Meredith E. Jackrel

Substituent-Based Modulation of Self-Assembly and Immunogenicity of Amphipathic Peptides 基于取代基的两亲性多肽自组装和免疫原性的调控

Advanced Science

IF14.1

2026-01-20

OAAI

Anirban Das; Ushasi Pramanik; Elise M. Brown; Chih-Yun Liu; Huan Gong; Jonathan Fascetti; Mark Gibson; Samuel Stealey; Silviya P. Zustiak; Cory Berkland; Piyoosh Sharma; Meredith E. Jackrel; Mark A. White; Jai S. Rudra

Matrin-3 forms spherical and wormlike assemblies that are modulated by RNA binding and ALS/FTD-associated mutations Matrin-3形成球形和虫状组装体，这些组装体的形成受到RNA结合和ALS/FTD相关突变的调控。

Molecular Cell

IF16.6

2025-09-19

OAAI

Macy L. Sprunger; Min Kyung Shinn; Sabrina K. Talir; Ken Lee; Rohit V. Pappu; Meredith E. Jackrel

Histidine-rich enantiomeric peptide coacervates enhance antigen sequestration and presentation to T cells 组氨酸富集的对映异构体肽凝聚物增强了抗原的隔离和向T细胞的呈递

CHEMICAL SCIENCE

IF7.4

2025-01-01

OAAI

Pramanik, Ushasi; Das, Anirban; Brown, Elise M.; Struckman, Heather L.; Wang, Huihao; Stealey, Samuel; Sprunger, Macy L.; Wasim, Abdul; Fascetti, Jonathan; Mondal, Jagannath; Silva, Jonathan R.; Zustiak, Silviya P.; Jackrel, Meredith E.; Rudra, Jai S.

Seeding-competent TDP-43 persists in human patient and mouse muscle

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2024-11-27

OAAI

Lynch, Eileen M.; Pittman, Sara; Daw, Jil; Ikenaga, Chiseko; Chen, Sheng; Dhavale, Dhruva D.; Jackrel, Meredith E.; Ayala, Yuna M.; Kotzbauer, Paul; Ly, Cindy V.; Pestronk, Alan; Lloyd, Thomas E.; Weihl, Conrad C.

HTRA1 disaggregates α-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species

NATURE COMMUNICATIONS

IF15.7

2024-03-18

OAAI

Chen, Sheng; Puri, Anuradhika; Bell, Braxton; Fritsche, Joseph; Palacios, Hector H.; Balch, Maurie; Sprunger, Macy L.; Howard, Matthew K.; Ryan, Jeremy J.; Haines, Jessica N.; Patti, Gary J.; Davis, Albert A.; Jackrel, Meredith E.

MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice MANF刺激自噬并恢复线粒体稳态治疗小鼠常染色体显性肾小管间质肾病

NATURE COMMUNICATIONS

IF15.7

2023-10-14

OAAI

Kim, Yeawon; Li, Chuang; Gu, Chenjian; Fang, Yili; Tycksen, Eric; Puri, Anuradhika; Pietka, Terri A.; Sivapackiam, Jothilingam; Kidd, Kendrah; Park, Sun-Ji; Johnson, Bryce G.; Kmoch, Stanislav; Duffield, Jeremy S.; Bleyer, Anthony J.; Jackrel, Meredith E.; Urano, Fumihiko; Sharma, Vijay; Lindahl, Maria; Chen, Ying Maggie

Amyloidogenic propensity of self-assembling peptides and their adjuvant potential for use as DNA vaccines 自组装肽的淀粉样蛋白生成倾向及其用作DNA疫苗的佐剂潜力

ACTA BIOMATERIALIA

IF9.6

2023-10-01

OAAI

Shrimali, Paresh C.; Chen, Sheng; Das, Anirban; Dreher, Rachel; Howard, Matthew K.; Ryan, Jeremy J.; Buck, Jeremy; Kim, Darren; Sprunger, Macy L.; Rudra, Jai S.; Jackrel, Meredith E.

Tuning Hsp104 specificity to selectively detoxify a-synuclein

MOLECULAR CELL

IF16.6

2023-09-01

OAAI

Mack, Korrie L.; Kim, Hanna; Barbieri, Edward M.; Lin, Jiabei; Braganza, Sylvanne; Jackrel, Meredith E.; Denizio, Jamie E.; Yan, Xiaohui; Chuang, Edward; Tariq, Amber; Cupo, Ryan R.; Castellano, Laura M.; Caldwell, Kim A.; Caldwell, Guy A.; Shorter, James

Probing the drivers of Staphylococcus aureus biofilm protein amyloidogenesis and disrupting biofilms with engineered protein disaggregases 探索金黄色葡萄球菌生物膜蛋白淀粉样蛋白生成的驱动因素，并用工程蛋白分解气体破坏生物膜

MBIO

IF4.7

2023-05-17

OAAI

Howard, Matthew K.; Miller, Karlie R.; Sohn, Brian S.; Ryan, Jeremy J.; Xu, Andy; Jackrel, Meredith E.

A Direct Interaction between the Utp6 Half-a-Tetratricopeptide Repeat Domain and a Specific Peptide in Utp21 Is Essential for Efficient Pre-rRNA Processing

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Champion, Erica A.; Lane, Bennett H.; Jackrel, Meredith E.; Regan, Lynne; Baserga, Susan J.

Therapeutic genetic variation revealed in diverse Hsp104 homologs

ELIFE

IF0

2020-12-15

OAAI

March, Zachary M.; Sweeney, Katelyn; Kim, Hanna; Yan, Xiaohui; Castellano, Laura M.; Jackrel, Meredith E.; Lin, JiaBei; Chuang, Edward; Gomes, Edward; Willicott, Corey W.; Michalska, Karolina; Jedrzejczak, Robert P.; Joachimiak, Andrzej; Caldwell, Kim A.; Caldwell, Guy A.; Shalem, Ophir; Shorter, James

Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma (vol 294, pg 11286, 2019)

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2019-11-01

OAAI

Ryan, Jeremy J.; Sprunger, Macy L.; Holthaus, Kayla; Shorter, James; Jackrel, Meredith E.

Quality Control in the ER: Misfolded Prohormones Get a Checkup

MOLECULAR CELL

IF16.6

2019-08-01

OAAI

Sprunger, Macy L.; Jackrel, Meredith E.

Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity

CELL REPORTS

IF6.9

2019-08-01

OAAI

Tariq, Amber; Lin, JiaBei; Jackrel, Meredith E.; Hesketh, Christina D.; Carman, Peter J.; Mack, Korrie L.; Weitzman, Rachel; Gambogi, Craig; Murillo, Oscar A. Hernandez; Sweeny, Elizabeth A.; Gurpinar, Esin; Yokom, Adam L.; Gates, Stephanie N.; Yee, Keolamau; Sudesh, Saurabh; Stillman, Jacob; Rizo, Alexandra N.; Southworth, Daniel R.; Shorter, James

Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2019-07-01

OAAI

Ryan, Jeremy J.; Sprunger, Macy L.; Holthaus, Kayla; Shorter, James; Jackrel, Meredith E.

Hsp104 and Potentiated Variants Can Operate as Distinct Nonprocessive Translocases

BIOPHYSICAL JOURNAL

IF3.1

2019-05-01

OAAI

Durie, Clarissa L.; Lin, JiaBei; Scull, Nathaniel W.; Mack, Korrie L.; Jackrel, Meredith E.; Sweeny, Elizabeth A.; Castellano, Laura M.; Shorter, James; Lucius, Aaron L.

FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination FUS包涵体通过隔离kinesin-1和抑制微管分离作用来破坏RNA定位

JOURNAL OF CELL BIOLOGY

IF6.4

2017-03-15

OAAI

Yasuda, Kyota; Clatterbuck-Soper, Sarah F.; Jackrel, Meredith E.; Shorter, James; Mili, Stavroula

Protein-Remodeling Factors As Potential Therapeutics for Neurodegenerative Disease

FRONTIERS IN NEUROSCIENCE

IF3.2

2017-02-28

OAAI

Jackrel, Meredith E.; Shorter, James