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J

James Shorter

University of Pennsylvania
H指数:80
被引数:2.7万

个人简介

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教育背景

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工作经历

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荣誉奖项

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Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration

短链RNA分子伴侣促进抗聚集的TDP-43构象体以减轻神经退行性变化

Science
IF45.8
2026-05-070
PRE
Katie E. Copley; Jocelyn C. Mauna; Helen L. Danielson; Qizan Chen; Busra Ozguney; Marilyn Ngo; Longxin Xie; Ashleigh Smirnov; Matt Davis; Leland Mayne; Miriam Linsenmeier; Jack D. Rubien; Cristian A. Bergmann; Bede Portz; Bo Lim Lee; Hana M. Odeh; Longsheng Lai; Yi-Wei Chang; Martina Hallegger; Jernej Ule; Piera Pasinelli; Yan Poon; Jeetain Mittal; Nicolas L. Fawzi; Ben E. Black; Christopher J. Donnelly; Brigid K. Jensen; James Shorter
Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy

p38α介导的磷酸化与PRMT1介导的精氨酸甲基化在驱动TDP-43蛋白病中的对立作用

CELL REPORTS
IF6.9
2025-01-012
OAAI
Aikio, Mari; Odeh, Hana M.; Wobst, Heike J.; Lee, Bo Lim; Chan, Una; Mauna, Jocelyn C.; Mack, Korrie L.; Class, Bradley; Ollerhead, Thomas A.; Ford, Alice F.; Barbieri, Edward M.; Cupo, Ryan R.; Drake, Lauren E.; Smalley, Joshua L.; Lin, Yuan-Ta; Lam, Stephanie; Thomas, Reuben; Castello, Nicholas; Baral, Ashmita; Beyer, Jenna N.; Najar, Mohd A.; Dunlop, John; Gitler, Aaron D.; Javaherian, Ashkan; Kaye, Julia A.; Burslem, George M.; Brown, Dean G.; Donnelly, Christopher J.; Finkbeiner, Steven; Moss, Stephen J.; Brandon, Nicholas J.; Shorter, James
C-terminal frameshift variant of TDP-43 with pronounced aggregation-propensity causes rimmed vacuole myopathy but not ALS/FTD

具有明显聚集倾向的TDP-43的C末端移码变体引起边缘空泡肌病，但不引起ALS/FTD

ACTA NEUROPATHOLOGICA
IF9.3
2023-03-3112
OAAI
Ervilha Pereira, Pedro; Schuermans, Nika; Meylemans, Antoon; LeBlanc, Pontus; Versluys, Lauren; Copley, Katie E. E.; Rubien, Jack D. D.; Altheimer, Christopher; Peetermans, Myra; Debackere, Elke; Vanakker, Olivier; Janssens, Sandra; Baets, Jonathan; Verhoeven, Kristof; Lammens, Martin; Symoens, Sofie; De Paepe, Boel; Barmada, Sami J. J.; Shorter, James; De Bleecker, Jan L. L.; Bogaert, Elke; Dermaut, Bart
Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy
MOLECULAR NEURODEGENERATION
IF17.5
2022-12-0817
OAAI
Khalil, Bilal; Chhangani, Deepak; Wren, Melissa C.; Smith, Courtney L.; Lee, Jannifer H.; Li, Xingli; Puttinger, Christian; Tsai, Chih-Wei; Fortin, Gael; Morderer, Dmytro; Gao, Junli; Liu, Feilin; Lim, Chun Kim; Chen, Jingjiao; Chou, Ching-Chieh; Croft, Cara L.; Gleixner, Amanda M.; Donnelly, Christopher J.; Golde, Todd E.; Petrucelli, Leonard; Oskarsson, Bjorn; Dickson, Dennis W.; Zhang, Ke; Shorter, James; Yoshimura, Shige H.; Barmada, Sami J.; Rincon-Limas, Diego E.; Rossoll, Wilfried
Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses
JACS AU
IF8.7
2022-09-065
OAAI
Weil, Tatjana; Kirupakaran, Abbna; Le, My-Hue; Rebmann, Philipp; Mieres-Perez, Joel; Issmail, Leila; Conzelmann, Carina; Mueller, Janis A.; Rauch, Lena; Gilg, Andrea; Wettstein, Lukas; Gross, Ruediger; Read, Clarissa; Bergner, Tim; Palsson, Sandra Axberg; Uhlig, Nadja; Eberlein, Valentina; Woell, Heike; Klaerner, Frank-Gerrit; Stenger, Steffen; Kuemmerer, Beate M.; Streeck, Hendrik; Fois, Giorgio; Frick, Manfred; Braubach, Peter; Spetz, Anna-Lena; Grunwald, Thomas; Shorter, James; Sanchez-Garcia, Elsa; Schrader, Thomas; Muench, Jan

研究方向

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M
Meredith E. Jackrel
H 指数:25论文数:72被引数:2,514
郭
郭林
H 指数:30论文数:100被引数:5,729
C
Charlotte M. Fare
H 指数:15论文数:32被引数:1,528
J
JiaBei Lin
H 指数:16论文数:54被引数:768
A
Aaron D. Gitler
H 指数:76论文数:253被引数:2.8万
K
Korrie L. Mack
H 指数:14论文数:29被引数:952
E
Elizabeth A. Sweeny
H 指数:18论文数:39被引数:1,883
S
Susan Lindquist
H 指数:140论文数:582被引数:7.3万
H
Hana M. Odeh
H 指数:18论文数:38被引数:2,772
S
Sua Myong
H 指数:48论文数:195被引数:9,991