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A

Amanda Littlewood-Evans

Novartis
H指数:29
被引数:3,415

个人简介

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荣誉奖项

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A root cause analysis to identify the mechanistic drivers of immunogenicity against the anti-VEGF biotherapeutic brolucizumab
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2023-02-0114
PRE
Kearns, Jeffrey D.; Wassmann, Paul; Olgac, Ufuk; Fichter, Marie; Christen, Brigitte; Rubic-Schneider, Tina; Koepke, Stephan; Billy, Benjamin Cochin de; Ledieu, David; Andre, Cedric; Hawtin, Stuart; Fischer, Benoit; Moretti, Francesca; Hug, Christian; Bepperling, Alexander; Brannetti, Barbara; Mendez-Garcia, Celia; Littlewood-Evans, Amanda; Clemens, Andreas; Grosskreutz, Cynthia L.; Mehan, Pawan; Schmouder, Robert L.; Sasseville, Vito; Brees, Dominique; Karle, Anette C.
Anti-brolucizumab immune response as one prerequisite for rare retinal vasculitis/retinal vascular occlusion adverse events
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2023-02-0115
PRE
Karle, Anette C.; Wrobel, Matthias B.; Koepke, Stephan; Gutknecht, Michael; Gottlieb, Sascha; Christen, Brigitte; Rubic-Schneider, Tina; Pruimboom-Brees, Ingrid; Leber, Xavier Charles; Scharenberg, Meike; Maciejewski, Benjamin; Turner, Oliver; Saravanan, Chandra; Huet, Francois; Littlewood-Evans, Amanda; Clemens, Andreas; Grosskreutz, Cynthia L.; Kearns, Jeffrey D.; Mehan, Pawan; Schmouder, Robert L.; Sasseville, Vito; Brees, Dominique
Nonhematopoietic IRAK1 drives arthritis via chemoattractants
JCI INSIGHT
IF6.1
2022-07-083
OA
Hoyler, Thomas; Bannert, Bettina; Andre, Cedric; Beck, Damian; Boulay, Thomas; Buffet, David; Caesar, Nadja; Calzascia, Thomas; Dawson, Janet; Kyburz, Diego; Hennze, Robert; Huppertz, Christine; Littlewood-Evans, Amanda; Loetscher, Pius; Mertz, Kirsten D.; Niwa, Satoru; Robert, Gautier; Rush, James S.; Ruzzante, Giulia; Sarret, Sophie; Stein, Thomas; Touil, Ismahane; Wieczorek, Grazyna; Zipfel, Geraldine; Hawtin, Stuart; Junt, Tobias
Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-02-1624
PREAI
Markert, Christian; Thoma, Gebhard; Srinivas, Honnappa; Bollbuck, Birgit; Lueoend, Rainer M.; Miltz, Wolfgang; Waelchli, Rudolf; Wolf, Romain; Hinrichs, Juergen; Bergsdorf, Christian; Azzaoui, Kamal; Penno, Carlos A.; Klein, Kai; Wack, Nathalie; Jaeger, Petra; Hasler, Franziska; Beerli, Christian; Loetscher, Pius; Dawson, Janet; Wieczorek, Grazyna; Numao, Shin; Littlewood-Evans, Amanda; Roehn, Till A.
Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-08-2822
PREAI
Velcicky, Juraj; Wilcken, Rainer; Cotesta, Simona; Janser, Philipp; Schlapbach, Achim; Wagner, Trixie; Piechon, Philippe; Villard, Frederic; Bouhelal, Rochdi; Piller, Fabian; Harlfinger, Stephanie; Stringer, Rowan; Fehlmann, Dominique; Kaupmann, Klemens; Littlewood-Evans, Amanda; Haffke, Matthias; Gommermann, Nina
Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology
FRONTIERS IN IMMUNOLOGY
IF5.9
2020-04-3033
OAAI
Martin, Kea; Junker, Ursula; Tritto, Elaine; Sutter, Esther; Rubic-Schneider, Tina; Morgan, Hannah; Niwa, Satoru; Li, Jianping; Schlapbach, Achim; Walker, Dana; Bigaud, Marc; Beerli, Christian; Littlewood-Evans, Amanda; Rudolph, Bettina; Laisney, Marc; Ledieu, David; Beltz, Karen; Quancard, Jean; Bornancin, Frederic; Zamurovic Ribrioux, Natasa; Calzascia, Thomas
Requirement of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 Protease Activity for Fcγ Receptor-Induced Arthritis, but Not Fcγ Receptor-Mediated Platelet Elimination, in Mice
ARTHRITIS & RHEUMATOLOGY
IF10.9
2020-04-269
PREAI
Martin, Kea; Touil, Ratiba; Cvijetic, Grozdan; Israel, Laura; Kolb, Yeter; Sarret, Sophie; Valeaux, Stephanie; Degl'Innocenti, Elena; Le Meur, Thomas; Caesar, Nadja; Bardet, Maureen; Beerli, Christian; Zerwes, Hans-Guenter; Kovarik, Jiri; Beltz, Karen; Schlapbach, Achim; Quancard, Jean; Regnier, Catherine H.; Bigaud, Marc; Junt, Tobias; Wieczorek, Grazyna; Isnardi, Isabelle; Littlewood-Evans, Amanda; Bornancin, Frederic; Calzascia, Thomas
Small-molecule factor B inhibitor for the treatment of complement-mediated diseases
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2019-03-29153
OAAI
Schubart, Anna; Anderson, Karen; Mainolfi, Nello; Sellner, Holger; Ehara, Takeru; Adams, Christopher M.; Mac Sweeney, Aengus; Liao, Sha-Mei; Crowley, Maura; Littlewood-Evans, Amanda; Sarret, Sophie; Wieczorek, Grazyna; Perrot, Ludovic; Dubost, Valerie; Flandre, Thierry; Zhang, Yuzhou; Smith, Richard J. H.; Risitano, Antonio M.; Karki, Rajeshri G.; Zhang, Chun; Valeur, Eric; Sirockin, Finton; Gerhartz, Bernd; Erbel, Paulus; Hughes, Nicola; Smith, Thomas M.; Cumin, Frederic; Argikar, Upendra A.; Haraldsson, Boerje; Mogi, Muneto; Sedrani, Richard; Wiesmann, Christian; Jaffee, Bruce; Maibaum, Juergen; Flohr, Stefanie; Harrison, Richard; Eder, Joerg
Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors

CDZ173 (Leniolisib) 的发现，代表了一类结构新颖的PI3K δ 选择性抑制剂

ACS MEDICINAL CHEMISTRY LETTERS
IF4
2017-09-0586
OAAI
Hoegenauer, Klemens; Soldermann, Nicolas; Zecri, Frederic; Strang, Ross S.; Grayeleau, Nadege; Wolf, Romain M.; Cooke, Nigel G.; Smith, Alexander B.; Hollingworth, Gregory J.; Blanz, Joachim; Gutmann, Sascha; Rummel, Gabriele; Littlewood-Evans, Amanda; Burkhart, Christoph
Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis

对伤害感受，炎症和血管生成具有调节作用的有效和口服活性的GPR4拮抗剂的设计和合成

BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2017-08-0122
PREAI
Miltz, Wolfgang; Velcicky, Juraj; Dawson, Janet; Littlewood-Evans, Amanda; Ludwig, Marie-Gabrielle; Seuwen, Klaus; Feifel, Roland; Oberhauser, Berndt; Meyer, Arndt; Gabriel, Daniela; Nash, Mark; Loetscher, Pius
A Novel Potent Oral Series of VEGFR2 Inhibitors Abrogate Tumor Growth by Inhibiting Angiogenesis
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2015-12-2135
PREAI
Bold, Guido; Schnell, Christian; Furet, Pascal; McSheehy, Paul; Brueggen, Josef; Mestan, Juergen; Manley, Paul W.; Drueckes, Peter; Burglin, Marion; Duerler, Ursula; Loretan, Jacqueline; Reuter, Robert; Wartmann, Markus; Theuer, Andreas; Bauer-Probst, Beatrice; Martiny-Baron, Georg; Allegrini, Peter; Goepfert, Arnaud; Wood, Jeanette; Littlewood-Evans, Amanda

研究方向

暂未获取到该数据
J
Janet Dawson
H 指数:30论文数:71被引数:2,990
G
Grazyna Wieczorek
H 指数:26论文数:63被引数:2,017
T
Tina Rubic-Schneider
H 指数:12论文数:34被引数:907
S
Sophie Sarret
H 指数:6论文数:14被引数:1,014
T
Tobias Junt
H 指数:45论文数:98被引数:1.5万
C
Christian Schnell
H 指数:41论文数:304被引数:1.1万
C
Christian Beerli
H 指数:21论文数:73被引数:1,749
J
Jeanette M. Wood
H 指数:51论文数:207被引数:1.0万
T
Thomas Calzascia
H 指数:25论文数:55被引数:3,022
J
Juraj Velcicky
H 指数:21论文数:51被引数:1,263