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J

Janet Dawson

Novartis
H指数:30
被引数:3,003

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Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-10-010
PRE
Velcicky, Juraj; Langlois, Jean-Baptiste; Wright, Michael; Janser, Philipp; Angst, Daniela; Arnold, Christelle; Beltz, Karen; Brenneisen, Silke; Dubois, Celine; Dawson, Janet; Fischer, Christian; Gommermann, Nina; Heizmann, Andreas; Ilic, Slavica; Machauer, Rainer; Maschlej, Magdalena; Monnerat, Sarah; Pflieger, Daniel; Ristov, Jacinda; Rubert, Joelle; Schwalm, Gunther; Smith, Daniel R.; Srinivas, Honnappa; Steiner, Roland; Stojanovic, Aleksandar; Troxler, Thomas; Unterreiner, Adeline; Vangrevelinghe, Eric; von Burg, Nicole; Wunderlich, Jennifer; Farady, Christopher J.; Mackay, Angela
A cereblon-based glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner

cereblon基 glue降解剂通过NEK7以依赖背景的方式调控NLRP3炎症小体

Cell Chemical Biology
IF7.2
2025-07-090
PRE
Aude Sylvain; Natacha Stoehr; Fupeng Ma; Artiom Cernijenko; Martin Schröder; Maryam Khoshouei; Melanie Vogelsanger; Michel Schoenboerner; Ashley Burke; Pasupuleti Rao; Jonathan M. Solomon; Joshiawa Paulk; Lei Xu; Janet Dawson; Damien Begue; Peggy Lefeuvre; Erik Ahrne; Andreas Hofmann; Callum J. Dickson; Philip Arabin; Alfred Zimmerlin; Michael Kiffe; Mirjam Froehlicher; Theresa Boersig; Azeddine Elhajouji; Murielle Brichet; Suchithra Menon; Shanming Liu; Matthias Mueller; Charles A. Wartchow; James Lin; Yamel Cardona Gloria; Sabine Dickhöfer; Alexander N.R. Weber; Tatjana Welzel; Jasmin Kuemmerle-Deschner; Christopher J. Farady; Robert Pulz; Frederic Bornancin; Dennis L. Buckley; Zuni I. Bassi
Discovery of Potent, Orally Bioavailable, Tricyclic NLRP3 Inhibitors

发现有效的口服生物可利用的三环NLRP3抑制剂

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-01-0414
PRE
Velcicky, Juraj; Janser, Philipp; Gommermann, Nina; Brenneisen, Silke; Ilic, Slavica; Vangrevelinghe, Eric; Stiefl, Nikolaus; Boettcher, Andreas; Arnold, Christelle; Malinverni, Claire; Dawson, Janet; Murgasova, Renata; Desrayaud, Sandrine; Beltz, Karen; Hinniger, Alexandra; Dekker, Carien; Farady, Christopher J.; Mackay, Angela
Nonhematopoietic IRAK1 drives arthritis via chemoattractants
JCI INSIGHT
IF6.1
2022-07-083
OA
Hoyler, Thomas; Bannert, Bettina; Andre, Cedric; Beck, Damian; Boulay, Thomas; Buffet, David; Caesar, Nadja; Calzascia, Thomas; Dawson, Janet; Kyburz, Diego; Hennze, Robert; Huppertz, Christine; Littlewood-Evans, Amanda; Loetscher, Pius; Mertz, Kirsten D.; Niwa, Satoru; Robert, Gautier; Rush, James S.; Ruzzante, Giulia; Sarret, Sophie; Stein, Thomas; Touil, Ismahane; Wieczorek, Grazyna; Zipfel, Geraldine; Hawtin, Stuart; Junt, Tobias
Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-02-1624
PREAI
Markert, Christian; Thoma, Gebhard; Srinivas, Honnappa; Bollbuck, Birgit; Lueoend, Rainer M.; Miltz, Wolfgang; Waelchli, Rudolf; Wolf, Romain; Hinrichs, Juergen; Bergsdorf, Christian; Azzaoui, Kamal; Penno, Carlos A.; Klein, Kai; Wack, Nathalie; Jaeger, Petra; Hasler, Franziska; Beerli, Christian; Loetscher, Pius; Dawson, Janet; Wieczorek, Grazyna; Numao, Shin; Littlewood-Evans, Amanda; Roehn, Till A.
Structure-Based and Property-Driven Optimization of N-Aryl Imidazoles toward Potent and Selective Oral RORγt Inhibitors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-11-1514
PREAI
Hoegenauer, Klemens; Kallen, Joerg; Jimenez-Nunez, Eloisa; Strang, Ross; Ertl, Peter; Cooke, Nigel G.; Hintermann, Samuel; Voegtle, Markus; Betschart, Claudia; McKay, Daniel J. J.; Wagner, Juergen; Ottl, Johannes; Beerli, Christian; Billich, Andreas; Dawson, Janet; Kaupmann, Klemens; Streiff, Markus; Gobeau, Nathalie; Harlfinger, Stephanie; Stringer, Rowan; Guntermann, Christine
Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors
SCIENTIFIC REPORTS
IF3.9
2017-10-1931
OAAI
Numao, Shin; Hasler, Franziska; Laguerre, Claire; Srinivas, Honnappa; Wack, Nathalie; Jager, Petra; Schmid, Andres; Osmont, Arnaud; Rothlisberger, Patrik; Houguenade, Jeremy; Bergsdorf, Christian; Dawson, Janet; Carte, Nathalie; Hofmann, Andreas; Markert, Christian; Hardaker, Liz; Billich, Andreas; Wolf, Romain M.; Penno, Carlos A.; Bollbuck, Birgit; Miltz, Wolfgang; Rohn, Till A.
A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia
SCIENCE SIGNALING
IF6.6
2017-09-1275
PREAI
Suply, Thomas; Hannedouche, Sebastien; Carte, Nathalie; Li, Jianping; Grosshans, Bianka; Schaefer, Michael; Raad, Layla; Beck, Valerie; Vidal, Solange; Hiou-Feige, Agnes; Beluch, Noemie; Barbieri, Samuel; Wirsching, Johann; Lageyre, Nadine; Hillger, Frank; Debon, Corinne; Dawson, Janet; Smith, Philip; Lannoy, Vincent; Detheux, Michel; Bitsch, Francis; Falchetto, Rocco; Bouwmeester, Tewis; Porter, Jeffrey; Baumgarten, Birgit; Mansfield, Keith; Carballido, Jose M.; Seuwen, Klaus; Bassilana, Frederic
Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis

对伤害感受，炎症和血管生成具有调节作用的有效和口服活性的GPR4拮抗剂的设计和合成

BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2017-08-0122
PREAI
Miltz, Wolfgang; Velcicky, Juraj; Dawson, Janet; Littlewood-Evans, Amanda; Ludwig, Marie-Gabrielle; Seuwen, Klaus; Feifel, Roland; Oberhauser, Berndt; Meyer, Arndt; Gabriel, Daniela; Nash, Mark; Loetscher, Pius
Deficiency of MALT1 Paracaspase Activity Results in Unbalanced Regulatory and Effector T and B Cell Responses Leading to Multiorgan Inflammation
JOURNAL OF IMMUNOLOGY
IF3.4
2015-04-15116
OAAI
Bornancin, Frederic; Renner, Florian; Touil, Ratiba; Sic, Heiko; Kolb, Yeter; Touil-Allaoui, Ismahane; Rush, James S.; Smith, Paul A.; Bigaud, Marc; Junker-Walker, Ursula; Burkhart, Christoph; Dawson, Janet; Niwa, Satoru; Katopodis, Andreas; Nuesslein-Hildesheim, Barbara; Weckbecker, Gisbert; Zenke, Gerhard; Kinzel, Bernd; Traggiai, Elisabetta; Brenner, Dirk; Bruestle, Anne; Paul, Michael St.; Zamurovic, Natasa; Mccoy, Kathy D.; Rolink, Antonius; Regnier, Catherine H.; Mak, Tak W.; Ohashi, Pamela S.; Patel, Dhavalkumar D.; Calzascia, Thomas

研究方向

暂未获取到该数据
A
Amanda Littlewood‐Evans
H 指数:29论文数:69被引数:3,426
A
Andreas Billich
H 指数:48论文数:218被引数:8,753
R
Rowan Stringer
H 指数:22论文数:63被引数:1,670
K
Klemens Kaupmann
H 指数:53论文数:128被引数:1.2万
J
Juraj Velcicky
H 指数:21论文数:51被引数:1,268
A
Anna Vulpetti
H 指数:36论文数:134被引数:5,089
G
Grazyna Wieczorek
H 指数:26论文数:63被引数:2,021
C
Christine Guntermann
H 指数:17论文数:33被引数:1,233
S
Samuel Hintermann
H 指数:23论文数:44被引数:1,541
D
David Orain
H 指数:18论文数:53被引数:1,410