未登录 BCL-XL-targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors Judd, Andrew S.; Bawa, Bhupinder; Buck, Wayne R.; Tao, Zhi-Fu; Li, Yingchun; Mitten, Michael J.; Bruncko, Milan; Catron, Nathaniel; Doherty, George; Durbin, Kenneth R.; Enright, Brian; Frey, Robin; Haasch, Deanna; Haman, Sandra; Haight, Anthony R.; Henriques, Tracy A.; Holms, James; Izeradjene, Kamel; Judge, Russell A.; Jenkins, Gary J.; Kunzer, Aaron; Leverson, Joel D.; Martin, Ruth L.; Mitra, Diya; Mittelstadt, Scott; Nelson, Lorne; Nimmer, Paul; Palma, Joann; Peterson, Richard; Phillips, Darren C.; Ralston, Sherry L.; Rosenberg, Saul H.; Shen, Xiaoqiang; Song, Xiaohong; Vaidya, Kedar R.; Wang, Xilu; Wang, Jin; Xiao, Yu; Zhang, Haichao; Zhang, Xinxin; Blomme, Eric A.; Boghaert, Erwin R.; Kalvass, John C.; Phillips, Andrew; Souers, Andrew J. 分享 收藏
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Synergistic therapeutic benefit by combining the antibody drug conjugate, depatux-m with temozolomide in pre-clinical models of glioblastoma with overexpression of EGFR Vaidya, Kedar S.; Mitten, Michael J.; Zelaya-Lazo, Adelyn L.; Oleksijew, Anatol; Alvey, Cory; Falls, Hugh D.; Mishra, Sasmita; Palma, Joann; Ansell, Peter; Phillips, Andrew C.; Reilly, Edward B.; Anderson, Mark; Boghaert, Erwin R. 分享 收藏
Targeting Multiple EGFR-expressing Tumors with a Highly Potent Tumor-selective Antibody-Drug Conjugate Anderson, Mark G.; Falls, Hugh D.; Mitten, Michael J.; Oleksijew, Anatol; Vaidya, Kedar S.; Boghaert, Erwin R.; Gao, Wenqing; Palma, Joann P.; Cao, Diana; Chia, Puey-Ling; John, Thomas; Gan, Hui K.; Scott, Andrew M.; Reilly, Edward B. 分享 收藏
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In vitro and in vivo characterization of novel MAT2A allosteric inhibitors Pei, Zhonghua; Alam, Muzaffar; Bhola, Neil; Cleary, Leah; Drummond, Jake; Fisher, Marcus; Fleury, Melissa; Garcia, Candy; Givmanesh, Atieh; Xin Linghu; McSpadden, Ethan; Mounir, Zineb; Neilan, Claire; Newby, Zach; Perumal, Senthil; Steel, Richard; Sutton, James; Vaidya, Kedar; Wagle, Marie-Claire; Wang, Jianhong; Yao, Bing; Lackner, Mark; Dillon, Michael P. 分享 收藏
Mat2A Inhibitors decrease growth, increase senescence and p53 stability in MTAP-deleted cancer cells Bhola, Neil; Givmanesh, Atieh; Wagle, Marie-Claire; Garcia, Candy; Vaidya, Kedar; Cleary, Leah; Pei, Zhonghua; Lackner, Mark; Mounir, Zineb 分享 收藏
PARG inhibitors exhibit synthetic lethality with XRCC1 deficiency and a cellular mechanism of action that is distinct from PARP inhibition Martin, Leenus; Cheng, Tzuling; James, Dominic I.; Begum, Habiba; Smith, Kate M.; Jordan, Allan; Waddell, Ian; Vaidya, Kedar; Fischer, Marcus; Yao, Bing; Drummond, Jason; Cleary, Leah; Martinez, Ruben; Sutton, James; Ravindran, Nandini; Joseph, James; Venetsanakos, Eleni; Dillon, Michael; Hager, Jeffrey H.; Belmont, Lisa D. 分享 收藏
Small-molecule antagonists of the Aryl Hydrocarbon Receptor (AhR) promote activation of human PBMCs in vitro and demonstrate significant impact on tumor growth and immune modulation in vivo Joseph, James; Gonzalez-Lopez, Marcos; Galang, Christina; Garcia, Candy; Lemar, Hadia; Lu, Jing; Vaidya, Kedar; Fischer, Marcus; Frey, Christian; Alam, Muzaffar; Yao, Bing; Dillon, Michael; Hager, Jeffrey H.; Venetsanakos, Eleni; Aswad, Fred 分享 收藏
Characterization of ABBV-221, a Tumor-Selective EGFR-Targeting Antibody Drug Conjugate Phillips, Andrew C.; Boghaert, Erwin R.; Vaidya, Kedar S.; Falls, Hugh D.; Mitten, Michael J.; DeVries, Peter J.; Benatuil, Lorenzo; Hsieh, Chung-Ming; Meulbroek, Jonathan A.; Panchal, Sanjay C.; Buchanan, Fritz G.; Durbin, Kenneth R.; Voorbach, Martin J.; Reuter, David R.; Mudd, Sarah R.; Loberg, Lise I.; Ralston, Sherry L.; Cao, Diana; Gan, Hui K.; Scott, Andrew M.; Reilly, Edward B. 分享 收藏
The Volume of Three-Dimensional Cultures of Cancer Cells In Vitro Influences Transcriptional Profile Differences and Similarities with Monolayer Cultures and Xenografted Tumors Boghaert, Erwin R.; Lu, Xin; Hessler, Paul E.; McGonigal, Thomas P.; Oleksijew, Anatol; Mitten, Michael J.; Foster-Duke, Kelly; Hickson, Jonathan A.; Santo, Vitor E.; Brito, Catarina; Uziel, Tamar; Vaidya, Kedar S. 分享 收藏
ABBV-399, a c-Met Antibody-Drug Conjugate that Targets Both MET-Amplified and c-Met-Overexpressing Tumors, Irrespective of MET Pathway Dependence Wang, Jieyi; Anderson, Mark G.; Oleksijew, Anatol; Vaidya, Kedar S.; Boghaert, Erwin R.; Tucker, Lora; Zhang, Qian; Han, Edward K.; Palma, Joann P.; Naumovski, Louie; Reilly, Edward B. 分享 收藏
ABT-414, an Antibody-Drug Conjugate Targeting a Tumor-Selective EGFR Epitope Phillips, Andrew C.; Boghaert, Erwin R.; Vaidya, Kedar S.; Mitten, Michael J.; Norvell, Suzanne; Falls, Hugh D.; DeVries, Peter J.; Cheng, Dong; Meulbroek, Jonathan A.; Buchanan, Fritz G.; McKay, Laura M.; Goodwin, Neal C.; Reilly, Edward B. 分享 收藏
Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification Wang, Jieyi; Goetsch, Liliane; Tucker, Lora; Zhang, Qian; Gonzalez, Alexandra; Vaidya, Kedar S.; Oleksijew, Anatol; Boghaert, Erwin; Song, Minghao; Sokolova, Irina; Pestova, Ekaterina; Anderson, Mark; Pappano, William N.; Ansell, Peter; Bhathena, Anahita; Naumovski, Louie; Corvaia, Nathalie; Reilly, Edward B. 分享 收藏
Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy Leverson, Joel D.; Phillips, Darren C.; Mitten, Michael J.; Boghaert, Erwin R.; Diaz, Dolores; Tahir, Stephen K.; Belmont, Lisa D.; Nimmer, Paul; Xiao, Yu; Ma, Xiaoju Max; Lowes, Kym N.; Kovar, Peter; Chen, Jun; Jin, Sha; Smith, Morey; Xue, John; Zhang, Haichao; Oleksijew, Anatol; Magoc, Terrance J.; Vaidya, Kedar S.; Albert, Daniel H.; Tarrant, Jacqueline M.; La, Nghi; Wang, Le; Tao, Zhi-Fu; Wendt, Michael D.; Sampath, Deepak; Rosenberg, Saul H.; Tse, Chris; Huang, David C. S.; Fairbrother, Wayne J.; Elmore, Steven W.; Souers, Andrew J. 分享 收藏
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Metastasis Suppressor KISS1 Seems to Reverse the Warburg Effect by Enhancing Mitochondrial Biogenesis Liu, Wen; Beck, Benjamin H.; Vaidya, Kedar S.; Nash, Kevin T.; Feeley, Kyle P.; Ballinger, Scott W.; Pounds, Keke M.; Denning, Warren L.; Diers, Anne R.; Landar, Aimee; Dhar, Animesh; Iwakuma, Tomoo; Welch, Danny R. 分享 收藏
ABT-414: An anti-EGFR antibody-drug conjugate as a potential therapeutic for the treatment of patients with squamous cell tumors Phillips, Andrew G.; Boghaert, Erwin R.; Vaidya, Kedar S.; Ansell, Peter J.; Shalinsky, David R.; Zhang, Yumin; Voorbach, Martin J.; Mudd, Sarah; Nolen, Kyle D.; Humerickhouse, Rod A.; Reilly, Edward B. 分享 收藏
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