David C.S. Huang - Publications, H-index & Citations

David C.S. Huang

walter & eliza hall institute

101H指数

575论文数

4.5W被引数

收录论文 173

发表时间

ZMYND8 Reads H3K36me2 to Activate CEBPE Transcription and Suppress Multiple Myeloma Progression through the Inhibition of Adaptive UPR Pathways ZMYND8通过读取H3K36me2来激活CEBPE转录，并通过抑制适应性UPR通路来抑制多发性骨髓瘤的进展。

ADVANCED SCIENCE

IF14.1

2025-05-10

OAAI

Xu, JX; Dong, XQ; Peng, Y; Yan, J; Xu, PP; Li, FY; Zhang, SW; Chen, LX; Meng, XJ; Wang, KN; Xing, MY; Li, WY; Huang, DCS; Zhao, Q; Chen, B

Re-appraising assays on permeabilized blood cancer cells testing venetoclax or other BH3 mimetic agents selectively targeting pro-survival BCL2 proteins 对渗透的血癌细胞进行再评估试验，测试维奈克拉或选择性靶向促生存BCL2蛋白的其他BH3模拟剂

CELL DEATH AND DIFFERENTIATION

IF15.4

2025-04-09

OAAI

Gong, Jia-Nan; Djajawi, Tirta M.; Moujalled, Donia M.; Pomilio, Giovanna; Khong, Tiffany; Zhang, Li-Ping; Fedele, Pasquale L.; Low, Michael S.; Anderson, Mary Ann; Riffkin, Christopher D.; White, Christine A.; Lan, Ping; Lessene, Guillaume; Herold, Marco J.; Strasser, Andreas; Spencer, Andrew; Grigoriadis, George; Wei, Andrew H.; van Delft, Mark F.; Roberts, Andrew W.; Huang, David C. S.

NONO interacts with nuclear PKM2 and directs histone H3 phosphorylation to promote triple-negative breast cancer metastasis NONO与核内PKM2相互作用，并指导组蛋白H3磷酸化以促进三阴性乳腺癌转移

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

IF12.8

2025-03-10

OAAI

Li, Qixiang; Ci, Hongfei; Zhao, Pengpeng; Yang, Dongjun; Zou, Yi; Chen, Panhai; Wu, Dongliang; Shangguan, Wenbing; Li, Wenyang; Meng, Xingjun; Xing, Mengying; Chen, Yuzhong; Zhang, Ming; Chen, Bing; Kong, Lingdong; Zen, Ke; Huang, David C. S.; Jiang, Zhi-Wei; Zhao, Quan

Differential regulation of BAX and BAK apoptotic activity revealed by small molecules 通过小分子揭示BAX和BAK凋亡活性的差异性调控

SCIENCE ADVANCES

IF12.5

2025-03-07

OAAI

Li, Kaiming; Yap, Yu Q.; Moujalled, Donia M.; Sumardy, Fransisca; Khakham, Yelena; Georgiou, Angela; Jahja, Michelle; Lew, Thomas E.; De Silva, Melanie; Luo, Meng-Xiao; Gong, Jia-nan; Yuan, Zheng; Birkinshaw, Richard W.; Czabotar, Peter E.; Lowes, Kym; Huang, David C. S.; Kile, Benjamin T.; Wei, Andrew H.; Dewson, Grant; van Delft, Mark F.

CENTRAL NERVOUS SYSTEM METASTASES ARE GENOMICALLY DIVERGENT FROM THEIR RESPECTIVE EXTRACRANIAL SITES

NEURO-ONCOLOGY

IF13.4

2024-11-11

PREAI

Huang, David; Bergagnini, Isabella; Hajiyeva, Sabina; Akerman, Meredith; Wong, Tamika; D'Amico, Randy; Boockvar, John; Vojnic, Morana

Leveraging synthetic lethality across EP300-mutant solid cancers through selective CBP degradation

MOLECULAR CANCER THERAPEUTICS

IF5.5

2024-06-10

PREAI

Sappal, Darshan; Adam, Ammar; Ahmad, Hafiz; Adams, Benjamin; Adhikari, Ketaki; Austin, Wesley; Bullock, Breanna; Di Bernardo, Julie; Dixon, Thomas; Daniels, Danette; Dominici, Claudi; Elliott, GiNell; Ethell, Brian; Gervais, Anais; Hossain, Md Imran; Huang, David; Lahr, David; La Bonte, Laura; Lin, Mei Yun; Mayhew, David; Mizeracka, Karolina; Negretti, Solymar; Nguyen, Tyler; Prifti, Olga; Schiller, Shawn; Sherbanee, Brenna; Terry, David; Ucisik, Nihan; Wittenborn, Elizabeth; Wilson, Molly M.; Zhou, Qianhe; Zimmerman, Mark

Co-operation of MCL-1 and BCL-XL anti-apoptotic proteins in stromal protection of MM cells from carfilzomib mediated cytotoxicity MCL-1和bcl-xl抗凋亡蛋白在基质保护MM细胞免受卡非佐米介导的细胞毒性中的协同作用

FRONTIERS IN ONCOLOGY

IF3.3

2024-04-08

OAAI

Galas-Filipowicz, Daria; Chavda, Selina J.; Gong, Jia-Nan; Huang, David C. S.; Khwaja, Asim; Yong, Kwee

Identification of selective CBP degraders with robust preclinical PK, PD, efficacy and safety across solid tumor indications

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Sappal, Darshan; Adam, Ammar; Ahmad, Hafiz; Adams, Benjamin; Adhikari, Ketaki; Austin, Wesley; Bullock, Breanna; Di Bernardo, Julie; Dixon, Thomas; Daniels, Danette; Dominici, Claudia; Elliot, GiNell; Ethell, Brian; Gervais, Anais; Hossain, Md Imran; Huang, David; Lahr, Dave; Lin, Mei Yun; Mayhew, David; Mizeracka, Karolina; Negretti, Solymar; Nguyen, Tyler; Prifti, Olga; Schiller, Shawn; Sherbanee, Brenna; Terry, David; Ucisik, Nihan; Wittenborn, Elizabeth; Zhou, Qianhe; Zimmerman, Mark; La Bonte, Laura

Discovery of potent and selective EP300 degraders with anti-cancer activity

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Zimmerman, Mark; Adam, Ammar; Ahmad, Hafiz; Adams, Benjamin; Adhikari, Ketaki; Austin, Wesley; Bullock, Breanna; Di Bernardo, Julie; Dixon, Thomas; Daniels, Danette; Dominici, Claudia; Elliot, GiNell; Ethell, Brian; Gervais, Anais; Hossain, Md Imran; Huang, David; Lahr, Dave; Lin, Mei Yun; Mayhew, David; Mizeracka, Karolina; Negretti, Solymar; Nguyen, Tyler; Prifti, Olga; Sappal, Darshan; Schiller, Shawn; Sherbanee, Brenna; Terry, David; Ucisik, Nihan; Wittenborn, Elizabeth; Zhou, Qianhe; La Bonte, Laura

FOXA2 activates HIF2α expression to promote tumor progression and is regulated by the E3 ubiquitin ligase VHL in renal cell carcinoma

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2024-01-01

OAAI

Yang, Dongjun; Li, Qixiang; Lu, Peifen; Wu, Dongliang; Li, Wenyang; Meng, Xingjun; Xing, Mengying; Shangguan, Wenbing; Chen, Bing; Yang, Jie; Zhang, Zhihong; Wang, Zengjun; Huang, David C. S.; Zhao, Quan

Discovery of potent and selective EP300 degraders with anti-cancer activity

MOLECULAR CANCER THERAPEUTICS

IF5.5

2023-12-01

PREAI

Zimmerman, Mark; Sappal, Darshan; Adam, Ammar; Adams, Benjamin; Adhikari, Ketaki; Austin, Wesley; Bullock, Breanna; DiBernardo, Julie; Dixon, Thomas; Elliot, GiNell; Ethell, Brian; Gervais, Anais; Hossain, Md Imran; Huang, David; Lahr, Dave; Lin, Mei Yun; Mayhew, David; Mizeracka, Karolina; Negretti, Solymar; Nguyen, Tyler; Prifti, Olga; Schiller, Shawn; Sherbanee, Brenna; Terry, David; Ucisik, Nihan; Wittenborn, Elizabeth; LaBonte, Laura; Daniels, Danette

Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells

CANCER DISCOVERY

IF33.3

2023-10-24

OAAI

Wang, Zilu; Burigotto, Matteo; Ghetti, Sabrina; Vaillant, Francois; Tan, Tao; Capaldo, Bianca D.; Palmieri, Michelle; Hirokawa, Yumiko; Tai, Lin; Simpson, Daniel S.; Chang, Catherine; Huang, Allan Shuai; Lieschke, Elizabeth; Diepstraten, Sarah T.; Kaloni, Deeksha; Riffkin, Chris; Huang, David C. S.; Li Wai Suen, Connie S. N.; Garnham, Alexandra L.; Gibbs, Peter; Visvader, Jane E.; Sieber, Oliver M.; Herold, Marco J.; Fava, Luca L.; Kelly, Gemma L.; Strasser, Andreas

Venetoclax treatment in patients with cancer has limited impact on circulating T and NK cells 维尼托克治疗癌症患者对循环T和NK细胞的影响有限

BLOOD ADVANCES

IF7.1

2023-06-15

OAAI

Teh, Charis E.; Peng, Hongke; Luo, Meng-Xiao; Tan, Tania; Trussart, Marie; Howson, Lauren J.; Chua, Chong Chyn; Muttiah, Christine; Brown, Fiona; Ritchie, Matthew E.; Wei, Andrew H.; Roberts, Andrew W.; Bryant, Vanessa L.; Anderson, Mary Ann; Lindeman, Geoffrey J.; Huang, David C. S.; Thijssen, Rachel; Gray, Daniel H. D.

The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase

BIOCHEMICAL JOURNAL

IF4.3

2023-05-12

OAAI

Pierotti, Catia L.; Jacobsen, Annette V.; Grohmann, Christoph; Dempsey, Ruby K.; Etemadi, Nima; Hildebrand, Joanne M.; Fitzgibbon, Cheree; Young, Samuel N.; Davies, Katherine A.; Kersten, Wilhelmus J. A.; Silke, John; Lowes, Kym N.; Huang, David C. S.; van Delft, Mark F.; Murphy, James M.; Lessene, Guillaume

The SMARCA4R1157W mutation facilitates chromatin remodeling and confers PRMT1/SMARCA4 inhibitors sensitivity in colorectal cancer

NPJ PRECISION ONCOLOGY

IF8

2023-03-15

OAAI

Zeng, Xiangwei; Yao, Bing; Liu, Jianpeng; Gong, Guan-Wen; Liu, Ming; Li, Jiahuang; Pan, Hua-Feng; Li, Qixiang; Yang, Dongjun; Lu, Peifen; Wu, Dongliang; Xu, Peipei; Chen, Bing; Chen, Panhai; Zhang, Ming; Zen, Ke; Jing, Jian; Huang, David C. S.; Chen, Dijun; Jiang, Zhi-Wei; Zhao, Quan

Mitochondrial E3 ubiquitin ligase MARCHF5 controls BAK apoptotic activity independently of BH3-only proteins

CELL DEATH AND DIFFERENTIATION

IF15.4

2022-09-28

PREAI

Huang, Allan Shuai; San Chin, Hui; Reljic, Boris; Djajawi, Tirta M.; Tan, Iris K. L.; Gong, Jia-Nan; Stroud, David A.; Huang, David C. S.; van Delft, Mark F.; Dewson, Grant

The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL

CELL DEATH & DISEASE

IF9.6

2022-04-01

OAAI

Jacobsen, Annette, V; Pierotti, Catia L.; Lowes, Kym N.; Au, Amanda E.; Zhang, Ying; Etemadi, Nima; Fitzgibbon, Cheree; Kersten, Wilhelmus J. A.; Samson, Andre L.; van Delft, Mark F.; Huang, David C. S.; Sabroux, Helene Jousset; Lessene, Guillaume; Silke, John; Murphy, James M.

Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK Dependent Cell Death

CANCER DISCOVERY

IF33.3

2022-03-08

OAAI

Garciaz, Sylvain; Guirguis, Andrew A.; Muller, Sebastian; Brown, Fiona C.; Chan, Yih-Chih; Motazediani, Ali; Rowe, Caitlin L.; Kuzich, James A.; Chan, Kah Lok; Tran, Kevin; Smith, Lorey; MacPherson, Laura; Liddicoat, Brian; Lam, Enid Y. N.; Caneque, Tatiana; Burr, Marian L.; Litalien, Veronique; Pomilio, Giovanna; Poplineau, Mathilde; Duprez, Estelle; Dawson, Sarah-Jane; Ramm, Georg; Cox, Andrew G.; Brown, Kristin K.; Huang, David C. S.; Wei, Andrew H.; McArthur, Kate; Rodriguez, Raphael; Dawson, Mark A.

Mesenchymal stromal cell apoptosis is required for their therapeutic function

NATURE COMMUNICATIONS

IF15.7

2021-11-11

121

OAAI

Pang, Swee Heng Milon; D'Rozario, Joshua; Mendonca, Senora; Bhuvan, Tejasvini; Payne, Natalie L.; Zheng, Di; Hisana, Assifa; Wallis, Georgia; Barugahare, Adele; Powell, David; Rautela, Jai; Huntington, Nicholas D.; Dewson, Grant; Huang, David C. S.; Gray, Daniel H. D.; Heng, Tracy S. P.

Comprehensive characterization of single-cell full-length isoforms in human and mouse with long-read sequencing

GENOME BIOLOGY

IF9.4

2021-11-11

OAAI

Tian, Luyi; Jabbari, Jafar S.; Thijssen, Rachel; Gouil, Quentin; Amarasinghe, Shanika L.; Voogd, Oliver; Kariyawasam, Hasaru; Du, Mei R. M.; Schuster, Jakob; Wang, Changqing; Su, Shian; Dong, Xueyi; Law, Charity W.; Lucattini, Alexis; Prawer, Yair David Joseph; Collar-Fernandez, Coralina; Chung, Jin D.; Naim, Timur; Chan, Audrey; Ly, Chi Hai; Lynch, Gordon S.; Ryall, James G.; Anttila, Casey J. A.; Peng, Hongke; Anderson, Mary Ann; Flensburg, Christoffer; Majewski, Ian; Roberts, Andrew W.; Huang, David C. S.; Clark, Michael B.; Ritchie, Matthew E.

研究方向