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D

David C.S. Huang

University of Melbourne
H指数:101
被引数:4.5万

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工作经历

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荣誉奖项

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The stress-sensing MARCH5 axis governs blood cancer apoptotic resilience via tractable protein–protein interactions

压力感应的MARCH5轴通过可调节的蛋白质-蛋白质相互作用调控血液癌症的凋亡抗性

Blood
IF23.1
2026-09-110
PRE
Thomas E. Lew; Mark F. van Delft; Luuk Heitink; Simon A. Cobbold; Christine A. White; Jason A. R. Bong; Philip H. Hittmeyer; Amelia H. Zhu; Vineet Vaibhav; Jumana Yousef; Laura Dagley; Christopher D. Riffkin; Angela Georgiou; Adrienne Hilton; Allan S. Huang; Yin Yuan; Miles B. Horton; Mark A. Dawson; Andrew W. Roberts; David C. S. Huang
Re-appraising assays on permeabilized blood cancer cells testing venetoclax or other BH3 mimetic agents selectively targeting pro-survival BCL2 proteins

对渗透的血癌细胞进行再评估试验，测试维奈克拉或选择性靶向促生存BCL2蛋白的其他BH3模拟剂

CELL DEATH AND DIFFERENTIATION
IF15.4
2025-04-090
OA
Gong, Jia-Nan; Djajawi, Tirta M.; Moujalled, Donia M.; Pomilio, Giovanna; Khong, Tiffany; Zhang, Li-Ping; Fedele, Pasquale L.; Low, Michael S.; Anderson, Mary Ann; Riffkin, Christopher D.; White, Christine A.; Lan, Ping; Lessene, Guillaume; Herold, Marco J.; Strasser, Andreas; Spencer, Andrew; Grigoriadis, George; Wei, Andrew H.; van Delft, Mark F.; Roberts, Andrew W.; Huang, David C. S.
NONO interacts with nuclear PKM2 and directs histone H3 phosphorylation to promote triple-negative breast cancer metastasis

NONO与核内PKM2相互作用，并指导组蛋白H3磷酸化以促进三阴性乳腺癌转移

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
IF12.8
2025-03-100
OA
Li, Qixiang; Ci, Hongfei; Zhao, Pengpeng; Yang, Dongjun; Zou, Yi; Chen, Panhai; Wu, Dongliang; Shangguan, Wenbing; Li, Wenyang; Meng, Xingjun; Xing, Mengying; Chen, Yuzhong; Zhang, Ming; Chen, Bing; Kong, Lingdong; Zen, Ke; Huang, David C. S.; Jiang, Zhi-Wei; Zhao, Quan
Differential regulation of BAX and BAK apoptotic activity revealed by small molecules

通过小分子揭示BAX和BAK凋亡活性的差异性调控

SCIENCE ADVANCES
IF12.5
2025-03-070
OA
Li, Kaiming; Yap, Yu Q.; Moujalled, Donia M.; Sumardy, Fransisca; Khakham, Yelena; Georgiou, Angela; Jahja, Michelle; Lew, Thomas E.; De Silva, Melanie; Luo, Meng-Xiao; Gong, Jia-nan; Yuan, Zheng; Birkinshaw, Richard W.; Czabotar, Peter E.; Lowes, Kym; Huang, David C. S.; Kile, Benjamin T.; Wei, Andrew H.; Dewson, Grant; van Delft, Mark F.
Leveraging synthetic lethality across EP300-mutant solid cancers through selective CBP degradation
MOLECULAR CANCER THERAPEUTICS
IF5.5
2024-06-100
PRE
Sappal, Darshan; Adam, Ammar; Ahmad, Hafiz; Adams, Benjamin; Adhikari, Ketaki; Austin, Wesley; Bullock, Breanna; Di Bernardo, Julie; Dixon, Thomas; Daniels, Danette; Dominici, Claudi; Elliott, GiNell; Ethell, Brian; Gervais, Anais; Hossain, Md Imran; Huang, David; Lahr, David; La Bonte, Laura; Lin, Mei Yun; Mayhew, David; Mizeracka, Karolina; Negretti, Solymar; Nguyen, Tyler; Prifti, Olga; Schiller, Shawn; Sherbanee, Brenna; Terry, David; Ucisik, Nihan; Wittenborn, Elizabeth; Wilson, Molly M.; Zhou, Qianhe; Zimmerman, Mark
Identification of selective CBP degraders with robust preclinical PK, PD, efficacy and safety across solid tumor indications
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Sappal, Darshan; Adam, Ammar; Ahmad, Hafiz; Adams, Benjamin; Adhikari, Ketaki; Austin, Wesley; Bullock, Breanna; Di Bernardo, Julie; Dixon, Thomas; Daniels, Danette; Dominici, Claudia; Elliot, GiNell; Ethell, Brian; Gervais, Anais; Hossain, Md Imran; Huang, David; Lahr, Dave; Lin, Mei Yun; Mayhew, David; Mizeracka, Karolina; Negretti, Solymar; Nguyen, Tyler; Prifti, Olga; Schiller, Shawn; Sherbanee, Brenna; Terry, David; Ucisik, Nihan; Wittenborn, Elizabeth; Zhou, Qianhe; Zimmerman, Mark; La Bonte, Laura
Discovery of potent and selective EP300 degraders with anti-cancer activity
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Zimmerman, Mark; Adam, Ammar; Ahmad, Hafiz; Adams, Benjamin; Adhikari, Ketaki; Austin, Wesley; Bullock, Breanna; Di Bernardo, Julie; Dixon, Thomas; Daniels, Danette; Dominici, Claudia; Elliot, GiNell; Ethell, Brian; Gervais, Anais; Hossain, Md Imran; Huang, David; Lahr, Dave; Lin, Mei Yun; Mayhew, David; Mizeracka, Karolina; Negretti, Solymar; Nguyen, Tyler; Prifti, Olga; Sappal, Darshan; Schiller, Shawn; Sherbanee, Brenna; Terry, David; Ucisik, Nihan; Wittenborn, Elizabeth; Zhou, Qianhe; La Bonte, Laura
Discovery of potent and selective EP300 degraders with anti-cancer activity
MOLECULAR CANCER THERAPEUTICS
IF5.5
2023-12-010
PRE
Zimmerman, Mark; Sappal, Darshan; Adam, Ammar; Adams, Benjamin; Adhikari, Ketaki; Austin, Wesley; Bullock, Breanna; DiBernardo, Julie; Dixon, Thomas; Elliot, GiNell; Ethell, Brian; Gervais, Anais; Hossain, Md Imran; Huang, David; Lahr, Dave; Lin, Mei Yun; Mayhew, David; Mizeracka, Karolina; Negretti, Solymar; Nguyen, Tyler; Prifti, Olga; Schiller, Shawn; Sherbanee, Brenna; Terry, David; Ucisik, Nihan; Wittenborn, Elizabeth; LaBonte, Laura; Daniels, Danette
Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells
CANCER DISCOVERY
IF33.3
2023-10-2422
OAAI
Wang, Zilu; Burigotto, Matteo; Ghetti, Sabrina; Vaillant, Francois; Tan, Tao; Capaldo, Bianca D.; Palmieri, Michelle; Hirokawa, Yumiko; Tai, Lin; Simpson, Daniel S.; Chang, Catherine; Huang, Allan Shuai; Lieschke, Elizabeth; Diepstraten, Sarah T.; Kaloni, Deeksha; Riffkin, Chris; Huang, David C. S.; Li Wai Suen, Connie S. N.; Garnham, Alexandra L.; Gibbs, Peter; Visvader, Jane E.; Sieber, Oliver M.; Herold, Marco J.; Fava, Luca L.; Kelly, Gemma L.; Strasser, Andreas
Venetoclax treatment in patients with cancer has limited impact on circulating T and NK cells

维尼托克治疗癌症患者对循环T和NK细胞的影响有限

BLOOD ADVANCES
IF7.1
2023-06-1512
OAAI
Teh, Charis E.; Peng, Hongke; Luo, Meng-Xiao; Tan, Tania; Trussart, Marie; Howson, Lauren J.; Chua, Chong Chyn; Muttiah, Christine; Brown, Fiona; Ritchie, Matthew E.; Wei, Andrew H.; Roberts, Andrew W.; Bryant, Vanessa L.; Anderson, Mary Ann; Lindeman, Geoffrey J.; Huang, David C. S.; Thijssen, Rachel; Gray, Daniel H. D.
Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK Dependent Cell Death
CANCER DISCOVERY
IF33.3
2022-03-0817
OAAI
Garciaz, Sylvain; Guirguis, Andrew A.; Muller, Sebastian; Brown, Fiona C.; Chan, Yih-Chih; Motazediani, Ali; Rowe, Caitlin L.; Kuzich, James A.; Chan, Kah Lok; Tran, Kevin; Smith, Lorey; MacPherson, Laura; Liddicoat, Brian; Lam, Enid Y. N.; Caneque, Tatiana; Burr, Marian L.; Litalien, Veronique; Pomilio, Giovanna; Poplineau, Mathilde; Duprez, Estelle; Dawson, Sarah-Jane; Ramm, Georg; Cox, Andrew G.; Brown, Kristin K.; Huang, David C. S.; Wei, Andrew H.; McArthur, Kate; Rodriguez, Raphael; Dawson, Mark A.

研究方向

暂未获取到该数据
A
Andreas Strasser
H 指数:135论文数:816被引数:8.4万
A
Andrew W. Roberts
H 指数:87论文数:465被引数:3.4万
G
Guillaume Lessène
H 指数:47论文数:158被引数:1.4万
P
Peter M. Colman
H 指数:65论文数:195被引数:2.2万
P
Peter E. Czabotar
H 指数:62论文数:216被引数:2.6万
M
Mark F. van Delft
H 指数:25论文数:51被引数:6,885
W
W. Douglas Fairlie
H 指数:53论文数:205被引数:2.0万
J
Jianan Gong
H 指数:21论文数:85被引数:3,458
D
David Segal
H 指数:27论文数:63被引数:4,052
J
Jerry M. Adams
H 指数:105论文数:415被引数:6.1万