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Progressive Degeneration and Adaptive Excitability in Dopamine D1 and D2 Receptor-Expressing Striatal Neurons Exposed to HIV-1 Tat and Morphine 暴露于HIV-1 Tat和吗啡的多巴胺D1和D2受体表达纹状体神经元的进行性变性和适应性兴奋性 Lark, Arianna R. S.; Silva, Lindsay K.; Nass, Sara R.; Marone, Michael G.; Ohene-Nyako, Michael; Ihrig, Therese M.; Marks, William D.; Yarotskyy, Viktor; McQuiston, A. Rory; Knapp, Pamela E.; Hauser, Kurt F. 分享 收藏
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Structure-Based Design and Development of Chemical Probes Targeting Putative MOR-CCR5 Heterodimers to Inhibit Opioid Exacerbated HIV-1 Infectivity 基于结构的设计和开发靶向假定的MOR-CCR5异二聚体的化学探针,以抑制阿片类药物加剧的HIV-1感染性 Huang, Boshi; Wang, Huiqun; Zheng, Yi; Li, Mengchu; Kang, Guifeng; Barreto-de-Souza, Victor; Nassehi, Nima; Knapp, Pamela E.; Selley, Dana E.; Hauser, Kurt F.; Zhang, Yan 分享 收藏
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Escalating morphine dosing in HIV-1 Tat transgenic mice with sustained Tat exposure reveals an allostatic shift in neuroinflammatory regulation accompanied by increased neuroprotective non-endocannabinoid lipid signaling molecules and amino acids 在持续暴露于Tat的HIV-1 Tat转基因小鼠中增加吗啡剂量,揭示了神经炎症调节的同种异体转变,并伴有神经保护性非内源性大麻素脂质信号分子和氨基酸的增加 Hermes, Douglas J.; Jacobs, Ian R.; Key, Megan C.; League, Alexis F.; Yadav-Samudrala, Barkha J.; Xu, Changqing; McLane, Virginia D.; Nass, Sara R.; Jiang, Wei; Meeker, Rick B.; Ignatowska-Jankowska, Bogna M.; Lichtman, Aron H.; Li, Zibo; Wu, Zhanhong; Yuan, Hong; Knapp, Pamela E.; Hauser, Kurt F.; Fitting, Sylvia 分享 收藏
Bivalent Ligand Aiming Putative Mu Opioid Receptor and Chemokine Receptor CXCR4 Dimers in Opioid Enhanced HIV-1 Entry 针对阿片类药物增强HIV-1进入的假定 μ 阿片受体和趋化因子受体CXCR4二聚体的二价配体 Ma, Hongguang; Wang, Huiqun; Li, Mengchu; Barreto-de-Souza, Victor; Reinecke, Bethany A.; Gunta, Rama; Zheng, Yi; Kang, Guifeng; Nassehi, Nima; Zhang, Huijun; An, Jing; Selley, Dana E.; Hauser, Kurt F.; Zhang, Yan 分享 收藏
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Pregnane steroidogenesis is altered by HIV-1 Tat and morphine: Physiological allopregnanolone is protective against neurotoxic and psychomotor effects HIV-1的Tat和吗啡会改变孕烷的类固醇生成: 生理性的allopregnanolone对神经毒性和精神运动作用具有保护作用 Paris, Jason J.; Liere, Philippe; Kim, Sarah; Mahdi, Fakhri; Buchanan, Meagan E.; Nass, Sara R.; Qrareya, Alaa N.; Salahuddin, Mohammed F.; Pianos, Antoine; Fernandez, Neike; Shariat-Madar, Zia; Knapp, Pamela E.; Schumacher, Michael; Hauser, Kurt F. 分享 收藏
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