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W

Wen Luo

mcgill university
H指数:16
被引数:792

个人简介

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荣誉奖项

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Novel regulators of heparan sulfate proteoglycans modulate cellular uptake of α-synuclein fibrils

硫酸乙酰肝素蛋白多糖的新型调节因子调控α-突触核蛋白纤维的细胞摄取

Communications Biology
IF5.1
2025-10-060
OA
Benoît Vanderperre; Amitha Muraleedharan; Marie-France Dorion; Frédérique Larroquette; Esther Del Cid Pellitero; Nishani Rajakulendran; Carol X.-Q. Chen; Roxanne Larivière; Charlotte Michaud-Tardif; Thomas Goiran; Rony Chidiac; Damien Lipuma; Graham MacLeod; Rhalena Thomas; Zhangjie Wang; Wolfgang E. Reintsch; Wen Luo; Irina Shlaifer; Fuming Zhang; Ke Xia; Zachary Steinhart; Robert J. Linhardt; Jean-François Trempe; Jian Liu; Thomas M. Durcan; Stephane Angers; Edward A. Fon
Female mice exhibit resistance to disease progression despite early pathology in a transgenic mouse model inoculated with alpha-synuclein fibrils
COMMUNICATIONS BIOLOGY
IF5.1
2025-02-220
OAAI
Tullo, Stephanie; Park, Janice; Gallino, Daniel; Park, Megan; Mar, Kristie; Novikov, Vladislav; Contreras, Rodrigo Sandoval; Patel, Raihaan; del Cid-Pellitero, Esther; Fon, Edward A.; Luo, Wen; Shlaifer, Irina; Durcan, Thomas M.; Prado, Marco A. M.; Prado, Vania F.; Devenyi, Gabriel A.; Chakravarty, M. Mallar
The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons (vol 19, 88, 2024)
MOLECULAR NEURODEGENERATION
IF17.5
2024-12-180
OAAI
Jones-Tabah, Jace; He, Kathy; Karpilovsky, Nathan; Senkevich, Konstantin; Deyab, Ghislaine; Pietrantonio, Isabella; Goiran, Thomas; Cousineau, Yuting; Nikanorova, Daria; Goldsmith, Taylor; del Cid Pellitero, Esther; Chen, Carol X. -Q.; Luo, Wen; You, Zhipeng; Abdian, Narges; Ahmad, Jamil; Ruskey, Jennifer A.; Asayesh, Farnaz; Spiegelman, Dan; Fahn, Stanley; Waters, Cheryl; Monchi, Oury; Dauvilliers, Yves; Dupre, Nicolas; Miliukhina, Irina; Timofeeva, Alla; Emelyanov, Anton; Pchelina, Sofya; Greenbaum, Lior; Hassin-Baer, Sharon; Alcalay, Roy N.; Milnerwood, Austen; Durcan, Thomas M.; Gan-Or, Ziv; Fon, Edward A.
The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons

帕金森氏病风险基因组织蛋白酶B促进多巴胺能神经元中纤维状 α-突触核蛋白清除，溶酶体功能和葡糖脑苷脂酶活性

MOLECULAR NEURODEGENERATION
IF17.5
2024-11-251
PRE
Jones-Tabah, Jace; He, Kathy; Karpilovsky, Nathan; Senkevich, Konstantin; Deyab, Ghislaine; Pietrantonio, Isabella; Goiran, Thomas; Cousineau, Yuting; Nikanorova, Daria; Goldsmith, Taylor; del Cid Pellitero, Esther; Chen, Carol X. -Q.; Luo, Wen; You, Zhipeng; Abdian, Narges; Ahmad, Jamil; Ruskey, Jennifer A.; Asayesh, Farnaz; Spiegelman, Dan; Fahn, Stanley; Waters, Cheryl; Monchi, Oury; Dauvilliers, Yves; Dupre, Nicolas; Miliukhina, Irina; Timofeeva, Alla; Emelyanov, Anton; Pchelina, Sofya; Greenbaum, Lior; Hassin-Baer, Sharon; Alcalay, Roy N.; Milnerwood, Austen; Durcan, Thomas M.; Gan-Or, Ziv; Fon, Edward A.
Modeling Parkinson’s disease pathology in human dopaminergic neurons by sequential exposure to α-synuclein fibrils and proinflammatory cytokines
Nature Neuroscience
IF20
2024-10-080
PRE
Armin Bayati; Riham Ayoubi; Adriana Aguila; Cornelia E. Zorca; Ghislaine Deyab; Chanshuai Han; Sherilyn Junelle Recinto; Emmanuelle Nguyen-Renou; Cecilia Rocha; Gilles Maussion; Wen Luo; Irina Shlaifer; Emily Banks; Ian McDowell; Esther Del Cid Pellitero; Xue Er Ding; Behrang Sharif; Philippe Séguéla; Moein Yaqubi; Carol X.-Q. Chen; Zhipeng You; Narges Abdian; Heidi M. McBride; Edward A. Fon; Jo Anne Stratton; Thomas M. Durcan; Patrick C. Nahirney; Peter S. McPherson
USP19 deubiquitinase inactivation regulates α-synuclein ubiquitination and inhibits accumulation of Lewy body-like aggregates in mice
NPJ PARKINSONS DISEASE
IF8.2
2023-11-283
OAAI
Schorova, Lenka; Bedard, Nathalie; Khayachi, Anouar; Ho, Hung-Hsiang; Bolivar-Pedroso, Joao; Huynh, Julie; Piccirelli, Mikaela; Wang, Yifei; Plourde, Marie; Luo, Wen; del Cid-Pellitero, Esther; Shlaifer, Irina; Castellanos-Montiel, Maria Jose; Yu, Ziqi; Valenzuela, Dulce Valeria Carrillo; Lacalle-Aurioles, Maria; Kriz, Anita; Ye, Yihong; Durcan, Thomas M.; Wing, Simon S.
MerTK is a mediator of alpha-synuclein fibril uptake by human microglia
BRAIN
IF11.7
2023-09-064
OAAI
Dorion, Marie-France; Yaqubi, Moein; Senkevich, Konstantin; Kieran, Nicholas W.; Macdonald, Adam; Chen, Carol X. Q.; Luo, Wen; Wallis, Amber; Shlaifer, Irina; Hall, Jeffery A.; Dudley, Roy W. R.; Glass, Ian A.; Stratton, Jo Anne; Fon, Edward A.; Bartels, Tim; Antel, Jack P.; Gan-or, Ziv; Durcan, Thomas M.; Healy, Luke M.
Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo
ACTA NEUROPATHOLOGICA
IF9.3
2022-09-1913
OAAI
Lackie, Rachel E.; de Miranda, Aline S.; Lim, Mei Peng; Novikov, Vladislav; Madrer, Nimrod; Karunatilleke, Nadun C.; Rutledge, Benjamin S.; Tullo, Stephanie; Brickenden, Anne; Maitland, Matthew E. R.; Greenberg, David; Gallino, Daniel; Luo, Wen; Attaran, Anoosha; Shlaifer, Irina; Pellitero, Esther Del Cid; Schild-Poulter, Caroline; Durcan, Thomas M.; Fon, Edward A.; Duennwald, Martin; Beraldo, Flavio H.; Chakravarty, M. Mallar; Bussey, Timothy J.; Saksida, Lisa M.; Soreq, Hermona; Choy, Wing-Yiu; Prado, Vania F.; Prado, Marco A. M.

研究方向

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E
Edward A. Fon
H 指数:56论文数:265被引数:2.3万
T
Thomas M. Durcan
H 指数:33论文数:345被引数:1.0万
I
Irina Shlaifer
H 指数:12论文数:61被引数:468
E
Esther del Cid‐Pellitero
H 指数:16论文数:45被引数:808
B
Binjie Yan
H 指数:9论文数:20被引数:280
D
Dan-Dan Gui
H 指数:7论文数:16被引数:125
Z
Zhong Ren
H 指数:28论文数:193被引数:2,931
Z
Ziv Gan‐Or
H 指数:63论文数:486被引数:2.1万
K
Konstantin Senkevich
H 指数:21论文数:138被引数:1,972
C
Carol X.‐Q. Chen
H 指数:15论文数:43被引数:829