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E

Edward A. Fon

mcgill university

56H指数
264论文数
2.4W被引数
收录论文 116
发表时间
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Cell type transcriptomic modules reveal shared molecular mechanisms in Alzheimer’s and Parkinson’s disease细胞类型转录组模块揭示阿尔茨海默病和帕金森病的共享分子机制
errGigaScience
IF3.9
err2026-05-21
err0
errOAAI
errAnwesha Bhattacharya; Edward A Fon; Alain Dagher; Yasser Iturria-Medina; Jo Anne Stratton; Chloe Savignac; Jack Stanley; Liam Hodgson; Badr Ait Hammou; David A Bennett; Danilo Bzdok
err分享
err收藏
α-Synuclein purification significantly impacts seed amplification assay performance and consistencyα-Synuclein纯化对种子扩增试验的性能和一致性有显著影响。
errActa Neuropathologica Communications
IF5.7
err2025-11-06
err0
errOAAI
errZaid A. M. Al-Azzawi; Nicholas R. G. Silver; Surabhi Mehra; Simeng Niu; Christopher Situ; Wen Luo; Irina Shlaifer; Martin Ingelsson; Bradley T. Hyman; Jean-François Trempe; Thomas M. Durcan; Joel C. Watts; Edward A. Fon
err分享
err收藏
Substrate recognition by the human mitochondrial processing peptidase and its processing of PINK1人源线粒体加工肽酶对底物的识别及其对PINK1的加工
errJournal of Biological Chemistry
IF3.9
err2025-10-27
err0
errOAAI
errAndrew N. Bayne; Danielle M. Simons; Naoto Soya; Karl Grenier; Gergely L. Lukacs; Edward A. Fon; Jean-François Trempe
err分享
err收藏
Neural networks reveal novel gene signatures in Parkinson disease from single-nuclei transcriptomes神经网络从单核转录组中揭示了帕金森病的新型基因特征
errnpj Parkinson's Disease
IF8.2
err2025-10-21
err0
errOAAI
errMichael R. Fiorini; Jialun Li; Edward A. Fon; Sali M. K. Farhan; Rhalena A. Thomas
err分享
err收藏
Novel regulators of heparan sulfate proteoglycans modulate cellular uptake of α-synuclein fibrils硫酸乙酰肝素蛋白多糖的新型调节因子调控α-突触核蛋白纤维的细胞摄取
errCommunications Biology
IF5.1
err2025-10-06
err0
errOAAI
errBenoît Vanderperre; Amitha Muraleedharan; Marie-France Dorion; Frédérique Larroquette; Esther Del Cid Pellitero; Nishani Rajakulendran; Carol X.-Q. Chen; Roxanne Larivière; Charlotte Michaud-Tardif; Thomas Goiran; Rony Chidiac; Damien Lipuma; Graham MacLeod; Rhalena Thomas; Zhangjie Wang; Wolfgang E. Reintsch; Wen Luo; Irina Shlaifer; Fuming Zhang; Ke Xia; Zachary Steinhart; Robert J. Linhardt; Jean-François Trempe; Jian Liu; Thomas M. Durcan; Stephane Angers; Edward A. Fon
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Activation of endogenous PRKN by structural derepression is linked to increased turnover of the E3 ubiquitin ligase内源性PRKN通过结构去抑制的激活与E3泛素连接酶的周转率增加相关
errAutophagy
IF14.3
err2025-07-18
err0
errOAAI
errFabienne C. Fiesel; Bernardo A. Bustillos; Jens O. Watzlawik; Carol X.Q. Chen; Martin H. Berryer; Jiazhen Zhang; Paige K. Boneski; Caleb S. Hayes; Jenny M. Bredenberg; Eric Deneault; Zhipeng You; Narges Abdien; Nathalia Aprahamian; Taylor M. Goldsmith; Zahra Baninameh; Liam T. Cocker; Haonan Zhang; Matthew S. Goldberg; Edward A. Fon; Jean-François Trempe; Satpal Virdee; Thomas M. Durcan; Wolfdieter Springer
err分享
err收藏
T cell responses towards PINK1 and α-synuclein are elevated in prodromal Parkinson's diseaseT细胞对PINK1和α-突触核蛋白的应答在帕金森病前驱期升高
errNPJ PARKINSONS DISEASE
IF8.2
err2025-05-26
err0
errOAAI
errJohansson, Emil; Freuchet, Antoine; Williams, Gregory P.; Michealis, Tanner; Frazier, April; Litvan, Irene; Goldman, Jennifer G.; Alcalay, Roy N.; Standaert, David G.; Amara, Amy W.; Stover, Natividad; Fon, Edward A.; Postuma, Ronald B.; Sidney, John; Sulzer, David; Lindestam Arlehamn, Cecilia S.; Sette, Alessandro
err分享
err收藏
LRRK2 rare-variant per-domain genetic burden in Parkinson's Disease: association confined to the kinase domainLRRK2罕见变异各结构域遗传负担在帕金森病中的关联：局限于激酶结构域
errNPJ PARKINSONS DISEASE
IF8.2
err2025-04-29
err0
errOAAI
errParlar, Sitki Cem; Senkevich, Konstantin; Yu, Eric; Ruskey, Jennifer A.; Ahmad, Jamil; Asayesh, Farnaz; Spiegelman, Dan; Waters, Cheryl; Monchi, Oury; Dauvilliers, Yves; Dupre, Nicolas; Greenbaum, Lior; Hassin-Baer, Sharon; Miliukhina, Irina; Timofeeva, Alla; Emelyanov, Anton; Pchelina, Sofya; Alcalay, Roy N.; Fon, Edward A.; Trempe, Jean-Francois
err分享
err收藏
Cell biology: Mitochondrial protease degrades unoccupied translocases upon import stress
errCURRENT BIOLOGY
IF7.5
err2025-04-21
err0
PREAI
errEldeeb, Mohamed A.; Shahid, Michael; Fon, Edward A.
err分享
err收藏
Female mice exhibit resistance to disease progression despite early pathology in a transgenic mouse model inoculated with alpha-synuclein fibrils
errCOMMUNICATIONS BIOLOGY
IF5.1
err2025-02-22
err0
errOAAI
errTullo, Stephanie; Park, Janice; Gallino, Daniel; Park, Megan; Mar, Kristie; Novikov, Vladislav; Contreras, Rodrigo Sandoval; Patel, Raihaan; del Cid-Pellitero, Esther; Fon, Edward A.; Luo, Wen; Shlaifer, Irina; Durcan, Thomas M.; Prado, Marco A. M.; Prado, Vania F.; Devenyi, Gabriel A.; Chakravarty, M. Mallar
err分享
err收藏
Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open迈向目标2035: EUbOPEN-一个公私合作伙伴关系，以开放和解锁生物学
errRSC MEDICINAL CHEMISTRY
IF3.6
err2025-01-01
err1
errOAAI
errTredup, Claudia; Ackloo, Suzanne; Beck, Hartmut; Brown, Peter J.; Bullock, Alex N.; Ciulli, Alessio; Dikic, Ivan; Edfeldt, Kristina; Edwards, Aled M.; Elkins, Jonathan M.; Farin, Henner F.; Fon, Edward A.; Gstaiger, Matthias; Guenther, Judith; Gustavsson, Anna-Lena; Haeberle, Sandra; Isigkeit, Laura; Huber, Kilian V. M.; Kotschy, Andras; Kraemer, Oliver; Leach, Andrew R.; Marsden, Brian D.; Matsui, Hisanori; Merk, Daniel; Montel, Florian; Mulder, Monique P. C.; Mueller, Susanne; Owen, Dafydd R.; Proschak, Ewgenij; Roehm, Sandra; Stolz, Alexandra; Sundstroem, Michael; von Delft, Frank; Willson, Timothy M.; Arrowsmith, Cheryl H.; Knapp, Stefan
err分享
err收藏
The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons (vol 19, 88, 2024)
errMOLECULAR NEURODEGENERATION
IF17.5
err2024-12-18
err0
errOAAI
errJones-Tabah, Jace; He, Kathy; Karpilovsky, Nathan; Senkevich, Konstantin; Deyab, Ghislaine; Pietrantonio, Isabella; Goiran, Thomas; Cousineau, Yuting; Nikanorova, Daria; Goldsmith, Taylor; del Cid Pellitero, Esther; Chen, Carol X. -Q.; Luo, Wen; You, Zhipeng; Abdian, Narges; Ahmad, Jamil; Ruskey, Jennifer A.; Asayesh, Farnaz; Spiegelman, Dan; Fahn, Stanley; Waters, Cheryl; Monchi, Oury; Dauvilliers, Yves; Dupre, Nicolas; Miliukhina, Irina; Timofeeva, Alla; Emelyanov, Anton; Pchelina, Sofya; Greenbaum, Lior; Hassin-Baer, Sharon; Alcalay, Roy N.; Milnerwood, Austen; Durcan, Thomas M.; Gan-Or, Ziv; Fon, Edward A.
err分享
err收藏
Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA)国家痴呆症研究联盟的影响: 加拿大衰老神经变性联盟 (CCNA)
errJOURNAL OF ALZHEIMERS DISEASE
IF3.1
err2024-12-05
err1
PREAI
errChertkow, Howard; Phillips, Natalie; Rockwood, Kenneth; Anderson, Nicole; Andrew, Melissa K.; Bartha, Robert; Beaudoin, Camille; Belanger, Nathalie; Bellec, Pierre; Belleville, Sylvie; Bergman, Howard; Best, Sarah; Bethell, Jennifer; Bherer, Louis; Black, Sandra; Borrie, Michael; Camicioli, Richard; Carrier, Julie; Cashman, Neil; Chan, Senny; Crowshoe, Lynden; Cuello, Claudio; Cynader, Max; Dang-Vu, Thanh; Das, Samir; Dixon, Roger A.; Ducharme, Simon; Einstein, Gillian; Evans, Alan C.; Fahnestock, Margaret; Feldman, Howard; Ferland, Guylaine; Finger, Elizabeth; Fisk, John D.; Fogarty, Jennifer; Fon, Edward; Gan-Or, Ziv; Gauthier, Serge; Greenwood, Carol; Henri-Bellemare, Charlie; Herrmann, Nathan; Hogan, David B.; Hsiung, Robin; Itzhak, Inbal; Jacklin, Kristen; Lanctot, Krista; Lim, Andrew; Mackenzie, Ian; Masellis, Mario; Maxwell, Colleen; Mcainey, Carrie; Mcgilton, Katherine; Mclaurin, Joanne; Mihailidis, Alex; Mohades, Zia; Montero-Odasso, Manuel; Morgan, Debra; Naglie, Gary; Nygaard, Haakon; O'Connell, Megan; Petersen, Ron; Pilon, Randi; Rajah, Maria Natasha; Rapoport, Mark; Roach, Pamela; Robillard, Julie M.; Rogaeva, Ekaterina; Rosa-Neto, Pedro; Rylett, Jane; Sadavoy, Joel; St George-Hyslop, Peter; Seitz, Dallas; Smith, Eric; Stefanovic, Bojana; Vedel, Isabelle; Walker, Jennifer D.; Wellington, Cheryl; Whitehead, Victor; Wittich, Walter
err分享
err收藏
The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons帕金森氏病风险基因组织蛋白酶B促进多巴胺能神经元中纤维状 α-突触核蛋白清除，溶酶体功能和葡糖脑苷脂酶活性
errMOLECULAR NEURODEGENERATION
IF17.5
err2024-11-25
err1
PREAI
errJones-Tabah, Jace; He, Kathy; Karpilovsky, Nathan; Senkevich, Konstantin; Deyab, Ghislaine; Pietrantonio, Isabella; Goiran, Thomas; Cousineau, Yuting; Nikanorova, Daria; Goldsmith, Taylor; del Cid Pellitero, Esther; Chen, Carol X. -Q.; Luo, Wen; You, Zhipeng; Abdian, Narges; Ahmad, Jamil; Ruskey, Jennifer A.; Asayesh, Farnaz; Spiegelman, Dan; Fahn, Stanley; Waters, Cheryl; Monchi, Oury; Dauvilliers, Yves; Dupre, Nicolas; Miliukhina, Irina; Timofeeva, Alla; Emelyanov, Anton; Pchelina, Sofya; Greenbaum, Lior; Hassin-Baer, Sharon; Alcalay, Roy N.; Milnerwood, Austen; Durcan, Thomas M.; Gan-Or, Ziv; Fon, Edward A.
err分享
err收藏
Disease-modifying therapies for Parkinson disease: lessons from multiple sclerosis
errNATURE REVIEWS NEUROLOGY
IF33.1
err2024-10-07
err0
PREAI
errKalia, Lorraine V.; Asis, Angelica; Arbour, Nathalie; Bar-Or, Amit; Bove, Riley; Di Luca, Daniel G.; Fon, Edward A.; Fox, Susan; Gan-Or, Ziv; Gommerman, Jennifer L.; Kang, Un Jung; Klawiter, Eric C.; Koch, Marcus; Kolind, Shannon; Lang, Anthony E.; Lee, Karen K.; Lincoln, Matthew R.; Macdonald, Penny A.; Mckeown, Martin J.; Mestre, Tiago A.; Miron, Veronique E.; Ontaneda, Daniel; Rousseaux, Maxime W. C.; Schlossmacher, Michael G.; Schneider, Raphael; Stoessl, A. Jon; Oh, Jiwon
err分享
err收藏
Activation of parkin by a molecular glue
errNATURE COMMUNICATIONS
IF15.7
err2024-09-19
err2
errOAAI
errSauve, Veronique; Stefan, Eric; Croteau, Nathalie; Goiran, Thomas; Fakih, Rayan; Bansal, Nupur; Hadzipasic, Adelajda; Fang, Jing; Murugan, Paramasivam; Chen, Shimin; Fon, Edward A.; Hirst, Warren D.; Silvian, Laura F.; Trempe, Jean-Francois; Gehring, Kalle
err分享
err收藏
Advancing Parkinson's Disease Research in Canada: The Canadian Open Parkinson Network (C-OPN) Cohort
errJOURNAL OF PARKINSONS DISEASE
IF5
err2024-09-19
err0
errOAAI
errCressatti, Marisa; Pinilla-Monsalve, Gabriel D.; Blais, Mathieu; Normandeau, Catherine P.; Degroot, Clotilde; Kathol, Iris; Bogard, Sarah; Bendas, Anna; Camicioli, Richard; Dupre, Nicolas; Gan-Or, Ziv; Grimes, David A.; Kalia, Lorraine, V; Macdonald, Penny A.; Mckeown, Martin J.; Martino, Davide; Miyasaki, Janis M.; Schlossmacher, Michael G.; Stoessl, A. Jon; Strafella, Antonio P.; Fon, Edward A.; Monchi, Oury
err分享
err收藏
Associations between neuromelanin depletion and cortical rhythmic activity in Parkinson's disease
errBRAIN
IF11.7
err2024-09-16
err0
errOAAI
errWiesman, Alex I.; Madge, Victoria; Fon, Edward A.; Dagher, Alain; Collins, D. Louis; Baillet, Sylvain
err分享
err收藏
Mitochondrial import stress and PINK1-mediated mitophagy: the role of the PINK1-TOMM-TIMM23 supercomplex线粒体输入压力和PINK1-mediated线粒体吞噬: PINK1-TOMM-TIMM23超复合物的作用
errAUTOPHAGY
IF14.3
err2024-04-14
err1
PREAI
errEldeeb, Mohamed A.; Fallahi, Armaan; Soumbasis, Andrea; Bayne, Andrew N.; Trempe, Jean-Francois; Fon, Edward A.
err分享
err收藏
An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders从干细胞衍生小胶质细胞的适应性方案及其在CSF1R-related疾病研究中的应用
errMOLECULAR NEURODEGENERATION
IF17.5
err2024-04-05
err2
errOAAI
errDorion, Marie-France; Casas, Diana; Shlaifer, Irina; Yaqubi, Moein; Fleming, Peter; Karpilovsky, Nathan; Chen, Carol X. -Q.; Nicouleau, Michael; Piscopo, Valerio E. C.; MacDougall, Emma J.; Alluli, Aeshah; Goldsmith, Taylor M.; Schneider, Alexandria; Dorion, Samuel; Aprahamian, Nathalia; Macdonald, Adam; Thomas, Rhalena A.; Dudley, Roy W. R.; Hall, Jeffrey A.; Fon, Edward A.; Antel, Jack P.; Stratton, Jo Anne; Durcan, Thomas M.; La Piana, Roberta; Healy, Luke M.
err分享
err收藏

研究方向

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合作学者
合作期刊
T
Tak W. Mak
H 指数: 181 · 论文数: 1.6K
A
Alexis Brice
H 指数: 153 · 论文数: 1.2K
G
Guy A. Rouleau
H 指数: 146 · 论文数: 1.3K
A
Andrés M. Lozano
H 指数: 140 · 论文数: 1.2K
N
Nicholas Wood
H 指数: 139 · 论文数: 1.1W
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