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R

Richard B. Silverman

Northwestern University

54H指数
597论文数
1.4W被引数
收录论文 246
发表时间
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Mechanism-Based Inactivation of Human Ornithine Aminotransferase by Ethynyl- and Nitrile-Substituted Cyclopentene Analogues of γ-Aminobutyric Acids基于机制的乙炔基和腈基取代的环戊烯γ-氨基丁酸类似物对人类鸟氨酸氨基转移酶的抑制
errJournal of the American Chemical Society
IF15.6
err2026-07-10
err0
PREAI
errFeng Wang; Mary C. Corrigan; Nhat Hoang Van Le; Dorothy Duan; Corine O. Smith; Graham R. Moran; Neil L. Kelleher; Dali Liu; Richard B. Silverman
err分享
err收藏
Targeting Conformational Flexibility of a Reactive Intermediate to Enhance Selectivity of a GABA Aminotransferase Inactivator靶向反应中间体的构象柔性以增强GABA转氨酶失活剂的专一性
errJournal of the American Chemical Society
IF15.6
err2026-02-19
err0
PREAI
errKoon Mook Kang; Abigail L. Vargas; Luana Assis Ferreira; Benjamin James Des Soye; Mary Corrigan; Cathy Kexin Zhang; Feng Wang; Dorothy Duan; Neil L. Kelleher; Andrea G. Hohmann; Dali Liu; Richard B. Silverman
err分享
err收藏
Enhancement of Potency and Selectivity of 2-Aminoquinoline-Based Human Neuronal Nitric Oxide Synthase Inhibitors
errJournal of Medicinal Chemistry
IF6.8
err2026-02-04
err0
PREAI
errAnas Ansari; Koon Mook Kang; Huiying Li; Christine D. Hardy; Athri D. Rathnayake; Amardeep Awasthi; Thomas L. Poulos; Richard B. Silverman
err分享
err收藏
Potent; Selective; and Brain Penetrant Ether-Linked 2-Aminopyridine Inhibitors of Human Neuronal Nitric Oxide Synthase with Excellent Oral Bioavailability具有良好口服生物利用度的人神经元一氧化氮合酶的强效、选择性和脑渗透剂醚连接的2-氨基吡啶抑制剂
errJournal of Medicinal Chemistry
IF6.8
err2026-02-02
err0
PREAI
errAnas Ansari; Radoslaw T. Chrzanowski; Huiying Li; Christine D. Hardy; Amardeep Awasthi; Thomas L. Poulos; Richard B. Silverman
err分享
err收藏
New Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma用于治疗黑素瘤的神经型一氧化氮合酶的新抑制剂
errJournal of Medicinal Chemistry
IF6.8
err2026-01-30
err0
errOAAI
errAmardeep Awasthi; Anika Patel; Huiying Li; Koon Mook Kang; Christine D. Hardy; Anas Ansari; Raghad Nowar; Md. Emtiaz Hasan; Sun Yang; Thomas L. Poulos; Richard B. Silverman
err分享
err收藏
Identification of a glia-associated amyloid β oligomer subtype and the rescue from reactive astrogliosis by inhibitor NU-9
errALZHEIMERS & DEMENTIA
IF11.1
err2025-12-18
err0
errOAAI
errKranz, Daniel L.; de Leon Velez, Omar; Ulupinar, Emel; Ozdinler, P. Hande; Silverman, Richard B.; Klein, William L.
err分享
err收藏
Modifications of NU-9, a potent protein aggregation inhibitor. Properties and activity in a cellular model of amyotrophic lateral sclerosisNU-9的修饰，一种强效蛋白质聚集抑制剂。特性及其在肌萎缩侧索硬化症细胞模型中的活性。
errBioorganic Chemistry
IF4.7
err2025-11-02
err0
PREAI
errMohamed F. Elmansy; Pedro Soares; Jose Ricardo D. dos Remedios; Raghad Nowar; Susan G. Fox; Anan Yu; William L. Klein; Richard I. Morimoto; Richard B. Silverman
err分享
err收藏
Truncated pyridinylbenzylamines: Potent, selective, and highly membrane permeable inhibitors of human neuronal nitric oxide synthase截短的吡啶基苄胺: 人类神经元一氧化氮合酶的有效，选择性和高度膜渗透性抑制剂
errBIOORGANIC & MEDICINAL CHEMISTRY
IF3
err2025-07-01
err0
PREAI
errVasu, Dhananjayan; Do, Ha T.; Li, Huiying; Hardy, Christine D.; Poulos, Thomas L.; Silverman, Richard B.
err分享
err收藏
A Tetrahydrobiopterin-Displacing Potent Neuronal Nitric Oxide Synthase Inhibitor with an Unprecedented Binding Mode
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2025-03-01
err0
PREAI
errWeerawarna, Pathum M.; Li, Huiying; Rathnayake, Athri D.; Hardy, Christine D.; Poulos, Thomas L.; Silverman, Richard B.
err分享
err收藏
Crosstalk Between nNOS/NO and COX-2 Enhances Interferon-Gamma-Stimulated Melanoma ProgressionnNOS/NO与COX-2之间的串扰增强干扰素-γ诱导的黑色素瘤进展
errCANCERS
IF4.4
err2025-01-31
err0
errOAAI
errPatel, Anika; Tong, Shirley; Roosan, Moom R.; Syed, Basir; Awasthi, Amardeep; Silverman, Richard B.; Yang, Sun
err分享
err收藏
Protection against Amyloid-β Aggregation and Ferroptosis/Oxytosis Toxicity by Arylpyrazolones: Alzheimer's Disease Therapeutics
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2025-01-24
err0
PREAI
errSoares, Pedro; Rahaman, Mizzanoor; Maher, Pamela; Silverman, Richard B.
err分享
err收藏
Synthesis of Oxabicyclo[3.2.1]octan-3-ol Scaffold via Burgess Reagent Mediated Cyclodehydration of δ-Diols under Acidic Conditions
errORGANIC LETTERS
IF5
err2025-01-06
err0
PREAI
errElmansy, Mohamed F.; dos Remedios, Jose Ricardo D.; Silverman, Richard B.
err分享
err收藏
Efficacy of GABA aminotransferase inactivator OV329 in models of neuropathic and inflammatory pain without tolerance or addictionGABA转氨酶失活剂OV329在神经病理性疼痛和炎症性疼痛模型中的疗效，且无耐受或成瘾性
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-12-30
err0
PREAI
errWirt, Jonah L.; Ferreira, Luana Assis; Jesus, Carlos Henrique Alves; Woodward, Taylor J.; Oliva, Idaira; Xu, Zhili; Crystal, Jonathon D.; Pepin, Robert H.; Silverman, Richard B.
err分享
err收藏
Design, Synthesis, and Mechanistic Studies of (R)-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase(vol 19,pg 1066,2024)
errACS CHEMICAL BIOLOGY
IF3.8
err2024-07-18
err0
PREAI
errDevitt, Allison N.; Vargas, Abigail L.; Zhu, Wei; Des Soye, Benjamin James; Butun, Fatma Ayaloglu; Alt, Tyler; Kaley, Nicholas; Ferreira, Glaucio M.; Moran, Graham R.; Kelleher, Neil L.; Liu, Dali; Silverman, Richard B.
err分享
err收藏
Synthesis of (2R,4S)-4-Amino-5-hydroxybicyclo[3.1.1]heptane-2-carboxylic Acid via an Asymmetric Intramolecular Mannich Reaction
errJOURNAL OF ORGANIC CHEMISTRY
IF3.6
err2024-06-10
err2
PREAI
errDukes, Adrian O.; Weerawarna, Pathum M.; Devitt, Allison N.; Silverman, Richard B.
err分享
err收藏
Design, Synthesis, and Mechanistic Studies of (R)-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase
errACS CHEMICAL BIOLOGY
IF3.8
err2024-04-17
err2
PREAI
errDevitt, Allison N.; Vargas, Abigail L.; Zhu, Wei; Des Soye, Benjamin James; Butun, Fatma Ayaloglu; Alt, Tyler; Kaley, Nicholas; Ferreira, Glaucio M.; Moran, Graham; Kelleher, Neil L.; Liu, Dali; Silverman, Richard B.
err分享
err收藏
Development of HH044, an orally bioavailable nNOS inhibitor, for the treatment of cutaneous melanoma
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errPatel, Anika; Tong, Shirley; Silverman, Richard B.; Yang, Sun
err分享
err收藏
Target Identification of a Class of Pyrazolone Protein Aggregation Inhibitor Therapeutics for Amyotrophic Lateral Sclerosis
errACS CENTRAL SCIENCE
IF10.4
err2023-12-20
err0
errOAAI
errWeerawarna, Pathum M.; Schiefer, Isaac T.; Soares, Pedro; Fox, Susan; Morimoto, Richard I.; Melani, Rafael D.; Kelleher, Neil L.; Luan, Chi-Hao; Silverman, Richard B.
err分享
err收藏
Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-07-11
err5
PREAI
errVasu, Dhananjayan; Do, Ha T. T.; Li, Huiying; Hardy, Christine D. D.; Awasthi, Amardeep; Poulos, Thomas L. L.; Silverman, Richard B. B.
err分享
err收藏
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis
errMEDICINAL RESEARCH REVIEWS
IF11.6
err2023-05-26
err4
errOAAI
errElmansy, Mohamed F.; Reidl, Cory T.; Rahaman, Mizzanoor; Ozdinler, P. Hande; Silverman, Richard B.
err分享
err收藏

研究方向

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合作学者
合作期刊
K
K. N. Houk
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Victor Nizet
H 指数: 123 · 论文数: 874
R
Richard I. Morimoto
H 指数: 121 · 论文数: 425
王
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N
Neil L. Kelleher
H 指数: 106 · 论文数: 714
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