Takahiko Aoyama - Publications, H-index & Citations

Takahiko Aoyama

NIHON UNIVERSITY

22H指数

192论文数

2.1K被引数

收录论文 18

发表时间

Paradigm shift in the management of drug development projects: artificial-intelligence-enabled parallel scenario execution for managing uncertainty 药物研发项目管理范式的转变：基于人工智能的并行情景执行以管理不确定性

Drug Discovery Today

IF7.5

2026-09-28

PREAI

Shinichi Tsuchiwata; Misaki Ishii; Takahiko Aoyama; Yasuhiro Tsuji

Population Pharmacokinetic Analysis and Modelling of Serum Uric Acid Dynamics in Patients Treated with Favipiravir Favipiravir治疗患者的血清尿酸动力学群体药代动力学分析与建模

Pharmaceuticals

IF4.8

2026-08-14

OAAI

Tomona Yamada; Hitoshi Kawasuji; Chika Ogami; Chihiro Hasegawa; Makito Kaneda; Daichi Yamaguchi; Satofumi Iida; Takahiko Aoyama; Yoshihiro Yamamoto; Yasuhiro Tsuji

Differential salivary disposition of linezolid and its two major metabolites (PNU-142300 and PNU-142586) after a single dose in healthy adults 单剂量给药后左氧沙星及其两种主要代谢物（PNU-142300和PNU-142586）在健康成人唾液中的差异分布

Journal of Antimicrobial Chemotherapy

IF3.6

2026-08-11

PREAI

Yasuhiro Tsuji; Hitoshi Kawasuji; Tomona Yamada; Fumihiro Kurosaki; Naoki Oikawa; Makito Kaneda; Takahiko Aoyama; Taketo Uchiyama; Yoshihiro Yamamoto

Leveraging ChatGPT for Vancomycin Therapeutic Drug Monitoring: Simulation Using Bayesian Estimation and Hyperparameter Optimization 利用ChatGPT进行万古霉素治疗药物监测：基于贝叶斯估计和超参数优化的模拟

Scientia Pharmaceutica

IF2.5

2026-04-29

PREAI

Kageyama, Akira; Aoyama, Takahiko; Maehara, Rikuya; Harada, Dai; Kawakubo, Takashi; Tsuji, Yasuhiro

A Unified Approach to Synthesizing Four Linezolid Metabolites that May Cause Thrombocytopenia 一种合成可能导致血小板减少症的四种利奈唑胺代谢物的统一方法

Pharmaceuticals

IF4.8

2025-11-28

OAAI

Naoki Oikawa; Natsu Inoue; Shogo Ishii; Takumi Goto; Hiroaki Saito; Fumihiro Kurosaki; Takahiro Aoyama; Yasuhiro Tsuji; Taketo Uchiyama

Generating and Modeling Virtual Patient Data from Published Population Pharmacokinetic Analyses: A Vancomycin Case Study 从已发表的群体药代动力学分析中生成和模拟虚拟患者数据：一项万古霉素案例研究

Pharmaceuticals 2025, Vol. 18, Page 1748

IF4.8

2025-11-18

OAAI

Moeko Suzuki; Hidefumi Kasai; Takahiko Aoyama; Yasuhiro Tsuji

A Multicenter Retrospective Observational Study on Drug-Drug Interactions between Opioid Analgesics and Immune Checkpoint Inhibitors in Cancer Patients

BIOLOGICAL & PHARMACEUTICAL BULLETIN

IF1.7

2025-11-01

PREAI

Miyasato, Akime; Hidaka, Noriaki; Funato, Miyui; Nakamura, Kazuyo; Ouchi, Ryusuke; Awaji, Kensaku; Aoyama, Takahiko; Kokubun, Hideya

High feasibility of salivary therapeutic drug monitoring in linezolid, but lower feasibility in tedizolid: a single-dose study in healthy subjects and a monocentric prospective exploratory study in patients who received linezolid 唾液治疗药物监测在利奈唑胺中具有高度可行性，但在 tedizolid 中可行性较低：一项在健康受试者中进行的单剂量研究以及一项在接收利奈唑胺治疗的患者中进行的单中心前瞻性探索性研究。

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

IF3.6

2025-07-01

PREAI

Kawasuji, Hitoshi; Tsuji, Yasuhiro; Miyaki, Keiko; Aoyama, Takahiko; Kurosaki, Fumihiro; Ezaki, Masayoshi; Koshiyama, Yuki; Takegoshi, Yusuke; Kaneda, Makito; Murai, Yushi; Kimoto, Kou; Nagaoka, Kentaro; Yamamoto, Yoshihiro

Population pharmacokinetic analysis identifies an absorption process model for mycophenolic acid in patients with renal transplant

CTS-CLINICAL AND TRANSLATIONAL SCIENCE

IF2.8

2024-12-04

PREAI

Suzuki, Yuki; Matsunaga, Noriko; Aoyama, Takahiko; Ogami, Chika; Hasegawa, Chihiro; Iida, Satofumi; To, Hideto; Kitahara, Takashi; Tsuji, Yasuhiro

Implementation-based approach for designing practical sensor network systems 基于实现的实用传感器网络系统设计方法

11TH ASIA-PACIFIC SOFTWARE ENGINEERING CONFERENCE, PROCEEDINGS

IF0

2024-09-06

PREAI

Minami, M; Saruwatari, S; Kashima, T; Morito, T; Morikawa, H; Aoyama, T

Kinetic-pharmacodynamic model of warfarin for prothrombin time-international normalized ratio in Japanese patients

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

IF3

2023-12-10

OAAI

Hirai, Toshinori; Aoyama, Takahiko; Tsuji, Yasuhiro; Itoh, Toshimasa; Matsumoto, Yoshiaki; Iwamoto, Takuya

Hyperkalemia by eplerenone or esaxerenone in the presence or absence of clarithromycin in hypertensive patients: a retrospective observational cohort study

JOURNAL OF HYPERTENSION

IF4.1

2023-01-20

PREAI

Hirai, Toshinori; Ueda, Shun; Ogura, Toru; Katayama, Kan; Dohi, Kaoru; Hosohata, Keiko; Aoyama, Takahiko; Matsumoto, Yoshiaki; Iwamoto, Takuya

Transcriptional inhibition of progressive renal disease by gene silencing pyrrole-imidazole polyamide targeting of the transforming growth factor-β1 promoter

KIDNEY INTERNATIONAL

IF12.6

2011-01-01

OAAI

Matsuda, Hiroyuki; Fukuda, Noboru; Ueno, Takahiro; Katakawa, Mayumi; Wang, Xiaofei; Watanabe, Takayoshi; Matsui, Sei-Ichi; Aoyama, Takahiko; Saito, Kosuke; Bando, Toshikazu; Matsumoto, Yoshiaki; Nagase, Hiroaki; Matsumoto, Koichi; Sugiyama, Hiroshi

Free-floating thrombus in right heart and massive pulmonary embolism migrating into pulmonary artery

CIRCULATION

IF38.6

2005-06-21

OAAI

Noji, Y; Kojima, T; Aoyama, T; Yamaguchi, M; Araki, T; Fujino, S; Yokota, K; Kumamoto, N; Nakaya, T; Takase, K; Shimizu, M; Mabuchi, H

Carotid artery intima-media thickness and brachial artery flow-mediated vasodilation in asymptomatic Japanese male subjects amongst apolipoprotein E phenotypes

JOURNAL OF INTERNAL MEDICINE

IF9.2

2002-08-20

PREAI

Haraki, T; Takegoshi, T; Kitoh, C; Wakasugi, T; Saga, T; Hirai, JI; Aoyama, T; Inazu, A; Mabuchi, H