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A

Anna K. H. Hirsch

pharmasciencehub

42H指数
444论文数
8.4K被引数
收录论文 167
发表时间
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Generative AI designs functional thiolation domains for reprogramming non-ribosomal peptide synthetases生成式人工智能设计功能性巯基化结构域以重编程非核糖体肽合酶
errNature Communications
IF15.7
err2026-09-22
err0
errOAAI
errEmre F. Bülbül; Seounggun Bang; Kevin George; Gabriele Bianchi; Prateek Raj; Seonyong Chung; Vincent Pauline; Ramon Hochstrasser; Hannah A. Minas; Walid A. M. Elgaher; Andreas M. Kany; Anna K. H. Hirsch; Steven Schmitt; Dirk W. Heinz; Olga V. Kalinina; Dietrich Klakow; Kenan A. J. Bozhüyük
err分享
err收藏
DockM8: an all-in-one open-source platform for consensus virtual screening in drug designDockM8：一个用于药物设计中共识虚拟筛选的全方位开源平台
errJournal of Cheminformatics
IF5.7
err2026-09-18
err0
errOAAI
errAntoine Lacour; Hamza Agha; Anna K. H. Hirsch; Andrea Volkamer
err分享
err收藏
Targeting the Energy-Coupling Factor Transporters: A Novel Antibiotic Drug Target in Streptococcus pneumoniae靶向能量偶联因子转运蛋白：肺炎链球菌的新型抗生素药物靶点
errJournal of Medicinal Chemistry
IF6.8
err2026-06-12
err0
errOAAI
errEleonora Diamanti; Amelieke J.H. Cremers; Yue Li; Ioulia Exapicheidou; Carole Baumann; Paddy Gibson; Atanaz Shams; Louise Martin; Rouven Becker; Inda Setyawati; Lucie Zeimetz; Jörg Haupenthal; Matthias Witschel; Dirk J. Slotboom; Jennifer Herrmann; Katharina Rox; Mostafa M. Hamed; Jan-Willem Veening; Anna K. H. Hirsch
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Identification of DksA as a novel pro-inflammatory mediator of Pseudomonas aeruginosa under conditions mimicking chronic cystic fibrosis lung infection鉴定DksA为铜绿假单胞菌在模拟囊性纤维化慢性肺部感染条件下的新型促炎介质
errVirulence
IF5.4
err2026-05-12
err0
errOAAI
errMerel Wauters; Laura Bollé; Gilles De Meester; Sara Van den Bossche; Lucia Grassi; Delphi Van Haver; Sara Dufour; Simon Devos; Francis Impens; Eva Van Braeckel; Anna K. H. Hirsch; Marvin Whiteley; Xavier Saelens; Aurélie Crabbé
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Exploring the Role of Pseudomonas aeruginosa Elastase in Lung Epithelial Barrier Dysfunction: Advancing toward Antivirulence Therapies探究铜绿假单胞菌弹性蛋白酶在肺上皮屏障功能障碍中的作用：迈向抗毒力疗法
errACS Infectious Diseases
IF3.8
err2026-04-10
err0
errOAAI
errRoya Shafiei; Alaa Alhayek; Lukas Hiller; Lorenz Latta; Tobias Neu; Ahmad Aljohmani; Sahar Abdollahibiroun; Eva-Maria Schönborn; Daniela Yildiz; Nicole Schneider-Daum; Claus-Michael Lehr; Jörg Haupenthal; Anna K. H. Hirsch
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A multivalent TAT–arginine-biodynamer conjugate targeting the bacterial cell envelope via specific membrane interactions一种多价的TAT-精氨酸-双动力学共轭物，通过特定的膜相互作用靶向细菌细胞包膜
errBIOMEDICINE & PHARMACOTHERAPY
IF7.5
err2026-04-02
err0
errOAAI
errMohamed A.M. Kamal; Walaa M. Metwally; Justine Bassil; Bart-Jan Niebuur; Tobias Kraus; Jennifer Herrmann; Marcus Koch; Anna K.H. Hirsch; Brigitta Loretz; Sangeun Lee; Claus-Michael Lehr
err分享
err收藏
Identification of Natural-Product Inhibitors of the 2C-Methyl-d-erythritol 4-Phosphate Pathway鉴定2C-甲基-D-赤藓糖-4-磷酸通路中的天然产物抑制剂
errACS Medicinal Chemistry Letters
IF4
err2026-03-13
err0
errOAAI
errEleonora Diamanti; Alaa Alhayek; Antoine Lacour; Mohammad Walid Shahrour; Daan Willocx; Boris Illarionov; Markus Fischer; Marc Stadler; Norbert Reiling; Jennifer Herrmann; Rolf Müller; Anna K. H. Hirsch
err分享
err收藏
Genome Mining Guided Identification of the Metallophore Delftichelin A from Delftia desertiGenome Mining指导下的Delftia deserti来源金属螯合剂Delftichelin A的鉴定
errJournal of Natural Products
IF3.6
err2026-03-01
err0
errOAAI
errde Kruijff, Martinus; Hiller, Lukas; Birkelbach, Joy; Decker, Tanya; Gotze, Sebastian; Kochems, Rebecca; Muller, Rolf; Hirsch, Anna K. H.; Beemelmanns, Christine
err分享
err收藏
Design of Poly-Catechol Biodynamers for Potentiation of Antibiotic Efficacy against Drug-Resistant Bacteria多酚儿茶酚双动态聚合物的设计以增强对抗药性细菌的抗生素疗效
errBiomacromolecules
IF5.4
err2026-02-23
err0
errOAAI
errLena Zeroug-Metz; Kristela Shehu; Justine Bassil; Justin Podlecki; Philipp Sonntag; Marcus Koch; Anastasia Christoulaki; Eric Buhler; Anna K. H. Hirsch; Annette Kraegeloh; Marc Schneider; Sangeun Lee
err分享
err收藏
Multiparameter Optimization of Pseudomonas aeruginosa Elastase Inhibitors for Systemic Administration
errJournal of Medicinal Chemistry
IF6.8
err2026-02-05
err0
errOAAI
errAhmed S. Abdelsamie; Jelena Konstantinović; Andreas M. Kany; Christian Schütz; Dominik Kolling; Samira Speicher; Andreas Klein; Roya Shafiei; Mélodie Bouté; Katharina Mundry; Yu Mi Park; Brigitta Loretz; Rolf Müller; Jean-Michel Sallenave; Claus-Michael Lehr; Jesko Koehnke; Katharina Rox; Jörg Haupenthal; Anna K. H. Hirsch
err分享
err收藏
Fragment Based Drug Discovery by Microscale Thermophoresis Targeting Klebsiella pneumoniae and Escherichia coli IspE基于微尺度热泳法的片段药物筛选，靶向 Klebsiella pneumoniae 和 Escherichia coli IspE
errDrug Design; Development and Therapy
IF0
err2025-12-18
err0
errOAAI
errDanica J Walsh; Daan Willocx; Rawia Hamid; Mostafa M Hamed; Anna KH Hirsch
err分享
err收藏
The One-Step Synthesis of Biologically Active Isochromans from Lignin-Derived Aromatic Monomers in Tunable Deep Eutectic Solvents从木质素衍生的芳香单体在可调深共熔溶剂中一步合成具有生物活性的异色烷。
errCHEMISTRY-A EUROPEAN JOURNAL
IF3.7
err2025-12-01
err0
errOAAI
errKottayi, Anjali; Afanasenko, Anastasiia M.; Castillo-garcia, Antonio A.; Elgaher, Walid A. M.; Haupenthal, Jorg; Hirsch, Anna K. H.; Barta, Katalin
err分享
err收藏
Toward Anti-Herpesviral PROTACs: Assessing the Challenges for Targeted Protein Degradation on the Example of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen抗疱疹病毒PROTACs的研究进展：以卡波西肉瘤相关疱疹病毒潜伏相关核抗原为例评估靶向蛋白降解的挑战
errCHEMMEDCHEM
IF3.4
err2025-11-01
err0
errOAAI
errBerwanger, Aylin; Stein, Saskia Catherina; Brandner, Sarah; Kany, Andreas Martin; Heinz, Sebastian; Loretz, Brigitta; Lehr, Claus-michael; Hirsch, Anna Katharina Herta; Lermyte, Frederik; Schulz, Thomas Friedrich; Empting, Martin
err分享
err收藏
Engineering an Artificial Myxopyronin Derivative with Enhanced Metabolic Stability via Mutasynthesis通过诱变改造具有增强的代谢稳定性的人工粘菌苷衍生物
errJACS AU
IF8.7
err2025-11-01
err0
PREAI
errKiefer, Alexander F.; Voltz, Alexander; Scherzer, Domen; Rebersek, Roman; Kany, Andreas M.; Prosser, Gareth; Neuber, Markus; Reiling, Norbert; Hirsch, Anna K. H.; Muller, Rolf
err分享
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Design, Synthesis, and Biological Evaluation of Mono- and Diamino-Substituted Squaramide Derivatives as Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthase单氨基和二氨基取代的squaramide衍生物的设计、合成及其作为分枝杆菌腺苷三磷酸(ATP)合酶强效抑制剂的生物评价
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-11-01
err0
PREAI
errPalme, Paul R.; Grover, Shipra; Abdelaziz, Rana; Mann, Lea; Kany, Andreas M.; Ouologuem, Lina; Bartel, Karin; Sonnenkalb, Lindsay; Reiling, Norbert; Hirsch, Anna K. H.; Schnappinger, Dirk; Rubinstein, John L.; Imming, Peter; Richter, Adrian
err分享
err收藏
A Novel Antimalarial Agent that Inhibits Protein Synthesis in Plasmodium falciparum一种新型抗疟疾药物，可抑制恶性疟原虫蛋白质合成
errAngewandte Chemie International Edition
IF16.9
err2025-10-20
err0
errOAAI
errDr. Patricia Bravo; Dr. Eleonora Diamanti; Dr. Mostafa M. Hamed; Dr. Lorenzo Bizzarri; Dr. Natalie Wiedemar; Armin Passecker; Prof. Dr. Nicolas M. B. Brancucci; Dr. Anna Albisetti; Christin Gumpp; Dr. Boris Illarionov; Dr. Markus Fischer; Dr. Matthias Witschel; Tobias Schehl; Dr. Hannes Hahne; Prof. Dr. Pascal Mäser; Dr. Matthias Rottmann; Prof. Dr. Anna K. H. Hirsch
err分享
err收藏
Targeting isoprenoid precursor biosynthesis in Klebsiella pneumoniae: Design, synthesis and evaluation of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) inhibitors靶向肺炎克雷伯菌异戊烯前体生物合成：1-脱氧-D-木酮糖-5-磷酸合酶（DXPS）抑制剂的设计、合成与评价
errBioorganic Chemistry
IF4.7
err2025-08-15
err0
errOAAI
errSidra Eisa; Antoine Lacour; Sandra Johannsen; Rawia Hamid; Prateek Raj; Dirk W. Heinz; Mostafa M. Hamed; Eleonora Diamanti; Anna K.H. Hirsch
err分享
err收藏
1-Deoxy-D-xylulose 5-phosphate synthase: structural perspectives on an essential enzyme in isoprenoid biosynthesis1-Deoxy-D-xylulose 5-磷酸合酶：异戊烯类生物合成中一种必需酶的结构视角
errJournal of Structural Biology
IF5.1
err2025-08-08
err0
errOAAI
errVictor O. Gawriljuk; Rick Oerlemans; Eswar R. Reddem; Robin M. Gierse; Anna K.H. Hirsch; Matthew R. Groves
err分享
err收藏
Tobramycin crosslinking improves the colloidal stability of arginine chitosan biodynamers for safe and efficient siRNA delivery妥布霉素交联提高了精氨酸壳聚糖生物动态胶束的胶体稳定性，以实现安全高效的siRNA递送
errINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
IF8.5
err2025-06-01
err0
PREAI
errLiu, Yun; Biesel, Achim; Kamal, Mohamed A. M.; Latta, Lorenz; Loretz, Brigitta; Hirsch, Anna K. H.; Lee, Sangeun; Lehr, Claus-Michael
err分享
err收藏
Domain adaptable language modeling of chemical compounds identifies potent pathoblockers for Pseudomonas aeruginosa域自适应语言模型用于化学化合物的建模，可识别出针对铜绿假单胞菌（Pseudomonas aeruginosa）的高效病原阻断剂。
errCOMMUNICATIONS CHEMISTRY
IF6.2
err2025-04-11
err0
errOAAI
errKallergis, Georgios; Asgari, Ehsannedin; Empting, Martin; Hirsch, Anna K. H.; Klawonn, Frank; Mchardy, Alice C.
err分享
err收藏

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