Chengjuan Chen

Chinese Academy of Medical Sciences and Peking Union Medical College

H指数:20

被引数:873

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Recent advances in interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitors and PROTACs

白细胞介素-1受体相关激酶4（IRAK4）抑制剂和PROTACs的最新进展

Chinese Chemical Letters

IF8.9

2025-02-170

PRE

Butyrolactone I blocks the transition of acute kidney injury to chronic kidney disease in mice by targeting JAK1

Butyrolactone I 通过靶向 JAK1 阻止小鼠急性肾损伤向慢性肾脏病的转变。

MEDCOMM

IF10.7

2025-01-210

OAAI

Emerging interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitors or degraders as therapeutic agents for autoimmune diseases and cancer

新兴的白细胞介素-1受体相关激酶4（IRAK4）抑制剂或降解剂作为自身免疫性疾病和癌症的治疗药物

ACTA PHARMACEUTICA SINICA B

IF14.6

2024-12-010

OAAI

A synthetic derivative of bioactive constituents from Isatis indigotica ameliorates hypersensitivity and arthritis by inhibiting JAK2-STAT3 pathway in mice

菘蓝生物活性成分的合成衍生物通过抑制JAK2-STAT3途径改善小鼠的超敏反应和关节炎

INTERNATIONAL IMMUNOPHARMACOLOGY

IF4.7

2023-11-012

PRE

JAK inhibition ameliorated experimental autoimmune encephalomyelitis by blocking GM-CSF-driven inflammatory signature of monocytes

ACTA PHARMACEUTICA SINICA B

IF14.6

2023-10-013

OAAI

Bone-derived MSCs encapsulated in alginate hydrogel prevent collagen-induced arthritis in mice through the activation of adenosine A2A/2B receptors in tolerogenic dendritic cells

封装在藻酸盐水凝胶中的骨源性MSCs通过激活耐受性树突状细胞中的腺苷A2A/2B受体来预防小鼠胶原诱导的关节炎

ACTA PHARMACEUTICA SINICA B

IF14.6

2023-06-0112

OAAI

Celastrol Targets Cullin-Associated and Neddylation-Dissociated 1 to Prevent Fibroblast-Myofibroblast Transformation against Pulmonary Fibrosis

ACS CHEMICAL BIOLOGY

IF3.8

2022-09-0815

PRE

A highly selective JAK3 inhibitor is developed for treating rheumatoid arthritis by suppressing γc cytokine-related JAK-STAT signal

SCIENCE ADVANCES

IF12.5

2022-08-1928

OAAI

JAK3 inhibitors for the treatment of inflammatory and autoimmune diseases: a patent review (2016-present)

JAK3抑制剂在炎症性和自身免疫性疾病治疗中的应用：专利综述（2016年至今）

EXPERT OPINION ON THERAPEUTIC PATENTS

IF4.6

2022-01-0620

PRE

Therapeutic potential of the target on NLRP3 inflammasome in multiple sclerosis

以NLRP3炎性体为靶点治疗多发性硬化的潜力

PHARMACOLOGY & THERAPEUTICS

IF12.5

2021-11-0140

PREAI

Studies of Interaction Mechanism between Pyrido [3,4-d] Pyrimidine Inhibitors and Mps1

MOLECULES

IF4.6

2021-08-211

OAAI

Divanillyl sulfone suppresses NLRP3 inflammasome activation via inducing mitophagy to ameliorate chronic neuropathic pain in mice

二香草酸砜通过诱导线粒体吞噬抑制NLRP3炎性体激活以改善小鼠慢性神经病理性疼痛

JOURNAL OF NEUROINFLAMMATION

IF10.1

2021-06-2450

OAAI

Emerging small-molecule inhibitors of the Bruton's tyrosine kinase (BTK): Current development

布鲁顿酪氨酸激酶 (BTK) 的新兴小分子抑制剂: 当前发展

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2021-05-0150

PREAI

Exploring a novel triptolide derivative possess anti-colitis effect via regulating T cell differentiation

INTERNATIONAL IMMUNOPHARMACOLOGY

IF4.7

2021-05-0110

PREAI

Methotrexate enhances antigen presentation and maturation of tumour antigen-loaded dendritic cells through NLRP3 inflammasome activation: a strategy for dendritic cell-based cancer vaccine

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY

IF4.2

2021-01-2111

OAAI

A novel triptolide derivative ZT01 exerts anti-inflammatory effects by targeting TAK1 to prevent macrophage polarization into pro-inflammatory phenotype

雷公藤内酯醇衍生物ZT01通过靶向TAK1阻止巨噬细胞极化为促炎表型发挥抗炎作用

BIOMEDICINE & PHARMACOTHERAPY

IF7.5

2020-06-0113

OAAI

Design, synthesis, and pharmacological evaluation of 4-or 6-phenyl-pyrimidine derivatives as novel and selective Janus kinase 3 inhibitors

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2020-04-0129

PREAI

Novel nitric oxide-releasing derivatives of triptolide as antitumor and anti-inflammatory agents: Design, synthesis, biological evaluation, and nitric oxide release studies

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2020-03-0120

PREAI

Isotalatizidine, a C19-diterpenoid alkaloid, attenuates chronic neuropathic pain through stimulating ERK/CREB signaling pathway-mediated microglial dynorphin A expression

JOURNAL OF NEUROINFLAMMATION

IF10.1

2020-01-1035

OAAI

Machine Learning Models Based on Molecular Fingerprints and an Extreme Gradient Boosting Method Lead to the Discovery of JAK2 Inhibitors

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2019-11-2040

PREAI

Chengjuan Chen

个人简介

教育背景

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