未登录

A

Amy E. Keating

massachusetts institute of technology

H指数:42

被引数:6,476

个人简介

暂无内容

教育背景

暂无内容

工作经历

暂无内容

荣誉奖项

暂无内容

Training bias and sequence alignments shape protein–peptide docking by AlphaFold and related methods

训练偏差和序列比对通过AlphaFold及相关方法塑造蛋白质-多肽对接。

Protein Science

IF5.2

2025-10-130

OAAI

Design of Specific Peptide Inhibitors of Toxin-Antitoxin-Mediated Antiphage Defense

毒素-抗毒素介导的抗噬菌体防御的特异性肽抑制剂设计

ACS SYNTHETIC BIOLOGY

IF3.9

2025-10-010

PRE

STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs

LIFE SCIENCE ALLIANCE

IF2.9

2025-04-140

OAAI

Marginal specificity in protein interactions constrains evolution of a paralogous family

蛋白质相互作用中的边缘特异性限制了旁系同源家族的进化

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-04-2513

OAAI

Combinatorial bZIP dimers display complex DNA-binding specificity landscapes

IF0

2022-04-01129

PRE

Indirect comparison of tisagenlecleucel and blinatumomab in pediatric relapsed/refractory acute lymphoblastic leukemia

IF7.1

2021-12-095

OAAI

A distributed residue network permits conformational binding specificity in a conserved family of actin remodelers

IF0

2021-12-028

OA

Data-driven computational protein design

CURRENT OPINION IN STRUCTURAL BIOLOGY

IF7

2021-08-0128

OAAI

Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator

IF15

2020-08-0183

OAAI

Shemesh, Or A.; Linghu, Changyang; Piatkevich, Kiryl D.; Goodwin, Daniel; Celiker, Orhan Tunc; Gritton, Howard J.; Romano, Michael F.; Gao, Ruixuan; Yu, Chih-Chieh (Jay); Tseng, Hua-An; Bensussen, Seth; Narayan, Sujatha; Yang, Chao-Tsung; Freifeld, Limor; Siciliano, Cody A.; Gupta, Ishan; Wang, Joyce; Pak, Nikita; Yoon, Young-Gyu; Ullmann, Jeremy F. P.; Guner-Ataman, Burcu; Noamany, Habiba; Sheinkopf, Zoe R.; Park, Won Min; Asano, Shoh; Keating, Amy E.; Trimmer, James S.; Reimer, Jacob; Tolias, Andreas S.; Bear, Mark F.; Tye, Kay M.; Han, Xue; Ahrens, Misha B.; Boyden, Edward S.

Peptide design by optimization on a data-parameterized protein interaction landscape

通过优化数据参数化蛋白质相互作用景观的肽设计

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2018-10-1547

OAAI

Targeting MUC1-C suppresses BCL2A1 in triple-negative breast cancer

Signal Transduction and Targeted Therapy

IF52.7

2018-05-120

OAAI

Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2018-01-1671

OAAI

Modular assembly of a protein nanotriangle using orthogonally interacting coiled coils

SCIENTIFIC REPORTS

IF3.9

2017-09-0553

OAAI

Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1

IF0

2017-06-0840

OA

Designing helical peptide inhibitors of protein-protein interactions

CURRENT OPINION IN STRUCTURAL BIOLOGY

IF7

2016-08-0166

OAAI

Rapid Optimization of Mcl-1 Inhibitors using Stapled Peptide Libraries Including Non-Natural Side Chains

使用包括非天然侧链的钉合肽库快速优化Mcl-1抑制剂

ACS CHEMICAL BIOLOGY

IF3.8

2016-02-1947

OAAI

Designing Peptide Inhibitors of Anti-Apoptotic Bcl-2 Family Proteins

BIOPHYSICAL JOURNAL

IF3.1

2016-02-010

OAAI

The Orientations of Large Aspect-Ratio Coiled-Coil Proteins Attached to Gold Nanostructures

IF12.1

2016-01-213

PREAI

Selectivity in subunit composition of Ena/VASP tetramers

Ena/VASP四聚体亚基组成的选择性

BIOSCIENCE REPORTS

IF4.7

2015-09-1012

OAAI

BH3 profiling predicts clinical response in a phase II clinical trial of ABT-199 (GDC-0199) in acute myeloid leukemia

CANCER RESEARCH

IF16.6

2015-08-014

PRE