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Data-driven computational protein design
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DOI：10.1016/j.sbi.2021.03.009.png)
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摘要
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Computational protein design can generate proteins not found in nature that adopt desired structures and perform novel functions. Although proteins could, in theory, be designed with ab initio methods, practical success has come from using large amounts of data that describe the sequences, structures, and functions of existing proteins and their variants. We present recent creative uses of multiple-sequence alignments, protein structures, and high-throughput functional assays in computational protein design. Approaches range from enhancing structure-based design with experimental data to building regression models to training deep neural nets that generate novel sequences. Looking ahead, deep learning will be increasingly important for maximizing the value of data for protein design.
Keyword:
DE-NOVO DESIGN
INTERACTION SPECIFICITY
NEURAL-NETWORKS
PREDICTION
PROFILES
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7
论文数:
3.8K
被引数:
1.3W
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