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Phase 2 study of oral CCR4 antagonist FLX475 (tivumecirnon) plus pembrolizumab in subjects with head and neck squamous cell carcinoma (HNSCC) previously treated with checkpoint inhibitor Muzaffar, Jameel; Kirtane, Kedar; Redman, Rebecca; Yang, Muh-Hwa; Kim, Tae Min; Liu, Stephen; Lynch, Ryan; Brahmer, Julie; LoRusso, Patricia; Henick, Brian; Kim, Sung-Bae; Feng, Yin-Hsun; Chisamore, Michael; Kassner, Paul; Brockstedt, Dirk; Nasrah, Nicole; Goyal, Rakesh; Ho, William Y.; Villaflor, Victoria 分享 收藏
HPK1 inhibits CD8+T cell effector gene expression following T cell activation Ames, Rachel Y.; Zhao, Rongqi; Mace, Parker; Grant, Adam; Xie, Guorui; Milestone, Heather; Grandcolas, Molly; Fang, Eva; Kiosea, Nicolae; Wong, Stephen; Brovarney, Martin; Jacobson, Scott; Nebalasca, Danilo; Arguello, Jorge; Gomez, Blanca; Kandala, Hiranmayee; Ko, Michelle Y.; Nguyen, Lan; Robles, Omar; Shibuya, Grant; Shakhmin, Anton A.; Tivitmahaisoon, Parcharee; Vi-Anh Vu; Younai, Ashkaan; Zibinsky, Mikhail; Subramanyam, Babu; Poon, Daniel; Ghomi, Mohsen Sabouri; Wustrow, David J.; Kassner, Paul D.; Katibah, George E.; Brockstedt, Dirk G. 分享 收藏
A combined mregDC and Treg signature associates with antitumor efficacy of CCR4 antagonist tivumecirnon FLX475 Grant, Adam; Adamik, Juraj; Qiu, Jingtao; Wert, Jacob; Grandcolas, Molly; Jacobson, Scott; Goyal, Rakesh K.; Ho, William; Ikeda, Shoji; Au, Marvin; Trujillo, Damian; Chisamore, Michael; Nagata, Denise de Almeida; Ghomi, Mohsen S.; Brockstedt, Dirk G.; Kassner, Paul D.; Katibah, George 分享 收藏
Clinical and molecular effects of oral CCR4 antagonist RPT193 in atopic dermatitis: A Phase 1 study Bissonnette, Robert; Dubois, Janet; Facheris, Paola; Del Duca, Ester; Kim, Madeline; Da Rosa, Joel Correa; Trujillo, Damian L.; Bose, Swaroop; Pagan, Angel D.; Wustrow, David; Brockstedt, Dirk G.; Wong, Brian; Kassner, Paul D.; Jankicevic, Jasmina; Ho, William; Cheng, Laurence E.; Guttman-Yassky, Emma 分享 收藏
Potent GCN2 Inhibitor Capable of Reversing MDSC-Driven T Cell Suppression Demonstrates In Vivo Efficacy as a Single Agent and in Combination with Anti-Angiogenesis Therapy Jackson, Jeffrey J.; Shibuya, Grant M.; Ravishankar, Buvana; Adusumilli, Lavanya; Bradford, Delia; Brockstedt, Dirk G.; Bucher, Cyril; Bui, Minna; Cho, Cynthia; Colas, Christoph; Cutler, Gene; Dukes, Adrian; Han, Xinping; Hu, Dennis X.; Jacobson, Scott; Kassner, Paul D.; Katibah, George E.; Ko, Michelle Yoo Min; Kolhatkar, Urvi; Leger, Paul R.; Ma, Anqi; Marshall, Lisa; Maung, Jack; Ng, Andrew A.; Okano, Akinori; Pookot, Deepa; Poon, Daniel; Ramana, Chandru; Reilly, Maureen K.; Robles, Omar; Schwarz, Jacob B.; Shakhmin, Anton A.; Shunatona, Hunter P.; Sreenivasan, Raashi; Tivitmahaisoon, Parcharee; Xu, Mengshu; Zaw, Thant; Wustrow, David J.; Zibinsky, Mikhail 分享 收藏
EBV+ tumors exploit tumor cell-intrinsic and -extrinsic mechanisms to produce regulatory T cell-recruiting chemokines CCL17 and CCL22 Jorapur, Aparna; Marshall, Lisa A.; Jacobson, Scott; Xu, Mengshu; Marubayashi, Sachie; Zibinsky, Mikhail; Hu, Dennis X.; Robles, Omar; Jackson, Jeffrey J.; Baloche, Valentin; Busson, Pierre; Wustrow, David; Brockstedt, Dirk G.; Talay, Oezcan; Kassner, Paul D.; Cutler, Gene 分享 收藏
Tumors establish resistance to immunotherapy by regulating Treg recruitment via CCR4 Marshall, Lisa A.; Marubayashi, Sachie; Jorapur, Aparna; Jacobson, Scott; Zibinsky, Mikhail; Robles, Omar; Hu, Dennis Xiaozhou; Jackson, Jeffrey J.; Pookot, Deepa; Sanchez, Jerick; Brovarney, Martin; Wadsworth, Angela; Chian, David; Wustrow, David; Kassner, Paul D.; Cutler, Gene; Wong, Brian; Brockstedt, Dirk G.; Talay, Oezcan 分享 收藏
Novel, Selective Inhibitors of USP7 Uncover Multiple Mechanisms of Antitumor Activity In Vitro and In Vivo Ohol, Yamini M.; Sun, Michael T.; Cutler, Gene; Leger, Paul R.; Hu, Dennis X.; Biannic, Berenger; Rana, Payal; Cho, Cynthia; Jacobson, Scott; Wong, Steve T.; Sanchez, Jerick; Shah, Niket; Pookot, Deepa; Abraham, Betty; Young, Kyle; Suthram, Silpa; Marshall, Lisa A.; Bradford, Delia; Kozon, Nathan; Han, Xinping; Okano, Akinori; Maung, Jack; Colas, Christophe; Schwarz, Jacob; Wustrow, David; Brockstedt, Dirk G.; Kassner, Paul D. 分享 收藏
Novel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as a Single Agent and in Combination with Checkpoint Inhibitors Robles, Omar; Jackson, Jeffrey J.; Marshall, Lisa; Talay, Oezcan; Chian, David; Cutler, Gene; Diokno, Raymond; Hu, Dennis X.; Jacobson, Scott; Karbarz, Emily; Kassner, Paul D.; Ketcham, John M.; McKinnell, Jenny; Meleza, Cesar; Reilly, Maureen K.; Riegler, Erin; Shunatona, Hunter P.; Wadsworth, Angela; Younai, Ashkaan; Brockstedt, Dirk G.; Wustrow, David J.; Zibinsky, Mikhail 分享 收藏
Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity Leger, Paul R.; Hu, Dennis X.; Biannic, Berenger; Bui, Minna; Han, Xinping; Karbarz, Emily; Maung, Jack; Okano, Akinori; Osipov, Maksim; Shibuya, Grant M.; Young, Kyle; Higgs, Christopher; Abraham, Betty; Bradford, Delia; Cho, Cynthia; Colas, Christophe; Jacobson, Scott; Ohol, Yamini M.; Pookot, Deepa; Rana, Payal; Sanchez, Jerick; Shah, Niket; Sun, Michael; Wong, Steve; Brockstedt, Dirk G.; Kassner, Paul D.; Schwarz, Jacob B.; Wustrow, David J. 分享 收藏
Discovery of potent and selective inhibitors of USP7 with anti-tumor activity in vitro and in vivo Ohol, Yamini M.; Sun, Michael; Leger, Paul; Hu, Dennis; Biannic, Berenger; Rana, Payal; Cho, Cynthia; Jacobson, Scott; Wong, Steve; Sanchez, Jerick; Han, Xinping; Young, Kyle; Okano, Akinori; Maung, Jack; Cutler, Gene; Shah, Nick; Adusumilli, Lavanya; Kaveri, Deepika; Talay, Oezcan; Pookot, Deepa; Abraham, Betty; Bradford, Delia; Kozon, Nathan; Colas, Christophe; Kim, Andrea; Schwarz, Jacob; Wustrow, David; Brockstedt, Dirk; Kassner, Paul 分享 收藏
Targeting the stress response kinase GCN2 to restore immunity in the tumor microenvironment Ravishankar, Buvana; Adusumilli, Lavanya; Pookot, Deepa Pookot; Huang, Emily; Sreenivasan, Raashi; Marshall, Lisa; Kaveri, Deepika; Talay, Oezcan; Suthram, Silpa; Miakicheva, Svetlana; Okal, Abood; Zibinsky, Mikhail; Jackson, Jeffrey; Shibuya, Grant; Leger, Paul; Tivitmahaisoon, Parcharee; Jacobson, Scott; Wong, Steve; Wadsworth, Angela; Sanchez, Jerick; Brovarney, Martin; Chian, David; Marubayashi, Sachie; Jorapur, Aparna; Bradford, Delia; Colas, Christophe; Cutler, Gene; Schwartz, Jacob; Wustrow, David; Kassner, Paul; Brockstedt, Dirk 分享 收藏
Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment Jackson, Jeffrey J.; Ketcham, John M.; Younai, Ashkaan; Abraham, Betty; Biannic, Berenger; Beck, Hilary P.; Bui, Minna H. T.; Chian, David; Cutler, Gene; Diokno, Raymond; Hu, Dennis X.; Jacobson, Scott; Karbarz, Emily; Kassner, Paul D.; Marshall, Lisa; McKinnell, Jenny; Meleza, Cesar; Okal, Abood; Pookot, Deepa; Reilly, Maureen K.; Robles, Omar; Shunatona, Hunter P.; Talay, Oezcan; Walker, James R.; Wadsworth, Angela; Wustrow, David J.; Zibinsky, Mikhail 分享 收藏
Discovery and optimization of potent and selective inhibitors of USP7 to enhance anti-tumor immunity and target tumor growth Abraham, Betty; Adusumilli, Lavanya; Biannic, Berenger; Bradford, Delia; Brovarney, Martin; Chian, David; Cutler, Gene; Han, Xinping; Hu, Dennis; Jacobson, Scott; Johnson, Sherra; Kassner, Paul; Kaveri, Deepika; Ketcham, John; Kim, Andrea; Leger, Paul; Marshall, Lisa; Marubayashi, Sachie; Maung, Jack; McKinnell, Jenny; Meleza, Cesar; Ohol, Yamini; Okano, Akinori; Peiser, Leanne; Pookot, Deepa; Rana, Payal; Schwarz, Jacob; Shah, Nick; Shibuya, Grant; Sun, Michael; Suthram, Silpa; Talay, Oezcan; Wadsworth, Angela; Wustrow, David; Young, Kyle; Napper, Andrew 分享 收藏
EBV associated tumors have increased regulatory T cell recruitment and are therefore a potential indication for treatment with potent and selective small molecule CCR4 antagonists Talay, Oezcan; Jorapur, Aparna; Jacobson, Scott; Marubayashi, Sachie; Marshall, Lisa; Suthram, Silpa; Robles, Omar; Ketcham, John; Reilly, Maureen K.; Younai, Ashkaan; Biannic, Berenger; Hu, Dennis; Bui, Minna; Schwarz, Jacob; Kassner, Paul; Cutler, Gene 分享 收藏
Potent and selective C-C chemokine receptor (CCR4) antagonists potentiate anti-tumor immune responses by inhibiting regulatory T cells (Treg) Talay, Oezcan; Marshall, Lisa; Meleza, Cesar; Reilly, Maureen K.; Robles, Omar; Zibisky, Mikhail; Okal, Abood; Seitz, Lisa; McKinnell, Jenny; Jacobson, Scott; Riegler, Erin; Karbaz, Emily; Chian, David; Wadsworth, Angela; Kassner, Paul; Wustrow, David; Fridman, Jordan S. 分享 收藏
High throughput siRNA screens uncover a high rate of USP8 and ESCRT pathway dependency in squamous carcinoma cell lines Zhong, Wendy; Cosgrove, Elissa; Swearingen, Elissa; Mann, Mike; Banerjee, Jayee; Watson, Vivienne; Jaeckel, Peter; Pfreimer, Mariana; Materna-Reichelt, Silvia; Beckmann, Holger; Kassner, Paul; Ruefli-Brasse, Astrid; Nolan-Stevaux, Olivier 分享 收藏
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