Richard A. Pfuetzner - Publications, H-index & Citations

Richard A. Pfuetzner

Department of Molecular and Cellular Physiology

37H指数

72论文数

1.2W被引数

收录论文 30

发表时间

SNARE disassembly requires Sec18/NSF side loading SNARE解聚需要Sec18/NSF侧向加载

Nature Structural & Molecular Biology

IF10.1

2025-07-02

OAAI

Yousuf A. Khan; K. Ian White; Richard A. Pfuetzner; Bharti Singal; Luis Esquivies; Garvey Mckenzie; Fang Liu; Katherine DeLong; Ucheor B. Choi; Elizabeth Montabana; Theresa Mclaughlin; William T. Wickner; Axel T. Brunger

Author Correction: Observing isolated synaptic vesicle association and fusion ex vivo 作者更正：观察离体条件下孤立的突触小泡的结合与融合

Nature Protocols

IF16

2025-06-30

PREAI

Jeremy Leitz; Chuchu Wang; Luis Esquivies; John J. Peters; Nisha Gopal; Richard A. Pfuetzner; Austin L. Wang; Axel T. Brunger

Observing isolated synaptic vesicle association and fusion ex vivo

NATURE PROTOCOLS

IF16

2024-07-02

PREAI

Leitz, Jeremy; Wang, Chuchu; Esquivies, Luis; Peters, John J.; Gopal, Nisha; Pfuetzner, Richard A.; Wang, Austin L.; Brunger, Axel T.

Beyond the MUN domain, Munc13 controls priming and depriming of synaptic vesicles 在MUN结构域之外，Munc13控制启动和剥夺突触小泡

CELL REPORTS

IF6.9

2024-05-01

OAAI

Leitz, Jeremy; Wang, Chuchu; Esquivies, Luis; Pfuetzner, Richard A.; Peters, John Jacob; Couoh-Cardel, Sergio; Wang, Austin L.; Brunger, Axel T.

Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering 中性溶血磷脂酰胆碱介导 α-突触核蛋白诱导的突触小泡聚集

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-10-26

OAAI

Lai, Ying; Zhao, Chunyu; Tian, Zhiqi; Wang, Chuchu; Fan, Jiaqi; Hu, Xiao; Tu, Jia; Li, Tihui; Leitz, Jeremy; Pfuetzner, Richard A.; Liu, Zhengtao; Zhang, Shengnan; Su, Zhaoming; Burre, Jacqueline; Li, Dan; Sudhof, Thomas C.; Zhu, Zheng-Jiang; Liu, Cong; Brunger, Axel T.; Diao, Jiajie

Sensory deficit screen identifies nsf mutation that differentially affects SNARE recycling and quality control

CELL REPORTS

IF6.9

2023-04-01

OAAI

Gao, Yan; Khan, Yousuf A.; Mo, Weike; White, K. Ian; Perkins, Matthew; Pfuetzner, Richard A.; Trapani, Josef G.; Brunger, Axel T.; Nicolson, Teresa

Structure-based design of a SARS-CoV-2 Omicron-specific inhibitor 一种SARS-CoV-2的Omicron特异性抑制剂的结构设计

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-03-20

OAAI

Yang, Kailu; Wang, Chuchu; Kreutzberger, Alex J. B.; White, K. Ian; Pfuetzner, Richard A.; Esquivies, Luis; Kirchhausen, Tomas; Brunger, Axel T.

Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein 靶向刺突蛋白前发夹中间体的未修饰肽对SARS-CoV-2感染的纳摩尔抑制

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2022-09-19

OAAI

Yang, Kailu; Wang, Chuchu; Kreutzberger, Alex J. B.; Ojha, Ravi; Kuivanen, Suvi; Couoh-Cardel, Sergio; Muratcioglu, Serena; Eisen, Timothy J.; White, K. Ian; Held, Richard G.; Subramanian, Subu; Marcus, Kendra; Pfuetzner, Richard A.; Esquivies, Luis; Doyle, Catherine A.; Kuriyan, John; Vapalahti, Olli; Balistreri, Giuseppe; Kirchhausen, Tom; Brunger, Axel T.

Structural conservation among variants of the SARS-CoV-2 spike postfusion bundle

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2022-04-01

OAAI

Yang, Kailu; Wang, Chuchu; White, K. Ian; Pfuetzner, Richard A.; Esquivies, Luis; Brunger, Axel T.

Prefused lysosomes cluster on autophagosomes regulated by VAMP8

CELL DEATH & DISEASE

IF9.6

2021-10-13

OAAI

Chen, Qixin; Hao, Mingang; Wang, Lei; Li, Linsen; Chen, Yang; Shao, Xintian; Tian, Zhiqi; Pfuetzner, Richard A.; Zhong, Qing; Brunger, Axel T.; Guan, Jun-Lin; Diao, Jiajie

Conformational Dynamics of SNARE Proteins during NSF-Mediated Disassembly

FASEB JOURNAL

IF4.2

2021-05-14

PREAI

Dunleavy, Katie; Matlock, Holland; Pfuetzner, Richard; Esquivies, Luis; Howells, Giovanni; Misra, Bishal; Gething, Claire; Brunger, Axel; Choi, Ucheor

Structures of neurexophilin-neurexin complexes reveal a regulatory mechanism of alternative splicing

EMBO JOURNAL

IF8.3

2019-09-30

OAAI

Wilson, Steven C.; Whiter, K. Ian; Zhou, Qiangjun; Pfuetzner, Richard A.; Choi, Ucheor B.; Suedhof, Thomas C.; Brunger, Axel T.

Structural principles of SNARE complex recognition by the AAA plus protein NSF

ELIFE

IF0

2018-09-10

OAAI

White, K. Ian; Zhao, Minglei; Choi, Ucheor B.; Pfuetzner, Richard A.; Brunger, Axel T.

NSF-mediated disassembly of on- and off-pathway SNARE complexes and inhibition by complexin

ELIFE

IF0

2018-07-09

OAAI

Choi, Ucheor B.; Zhao, Minglei; White, K. Ian; Pfuetzner, Richard A.; Esquivies, Luis; Zhou, Qiangjun; Brunger, Axel T.

Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18 Munc13和Munc18引发突触小泡的分子机制

NEURON

IF15

2017-08-01

181

OAAI

Lai, Ying; Choi, Ucheor B.; Leitz, Jeremy; Rhee, Hong Jun; Lee, Choongku; Altas, Bekir; Zhao, Minglei; Pfuetzner, Richard A.; Wang, Austin L.; Brose, Nils; Rhee, JeongSeop; Brunger, Axel T.

C-terminal domain of mammalian complexin-1 localizes to highly curved membranes 哺乳动物complexin-1的C端结构域定位于高度弯曲的膜

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2016-11-07

OAAI

Gong, Jihong; Lai, Ying; Li, Xiaohong; Wang, Mengxian; Leitz, Jeremy; Hu, Yachong; Zhang, Yunxiang; Choi, Ucheor B.; Cipriano, Daniel; Pfuetzner, Richard A.; Suedhof, Thomas C.; Yang, Xiaofei; Brunger, Axel T.; Diao, Jiajie

N-terminal domain of complexin independently activates calcium-triggered fusion 复合蛋白的N端结构域独立激活钙触发的融合

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2016-07-21

OAAI

Lai, Ying; Choi, Ucheor B.; Zhang, Yunxiang; Zhao, Minglei; Pfuetzner, Richard A.; Wang, Austin L.; Diao, Jiajie; Brunger, Axel T.

Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion

EMBO JOURNAL

IF8.3

2016-07-11

OAAI

Malmersjo, Seth; Di Palma, Serena; Diao, Jiajie; Lai, Ying; Pfuetzner, Richard A.; Wang, Austin L.; McMahon, Moira A.; Hayer, Arnold; Porteus, Matthew; Bodenmiller, Bernd; Brunger, Axel T.; Meyer, Tobias

Munc18a Does Not Alter Fusion Rates Mediated by Neuronal SNAREs, Synaptotagmin, and Complexin Munc18a不会改变由神经元网罗，突触结合蛋白和复合物介导的融合率

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2015-04-01

OAAI

Zhang, Yunxiang; Diao, Jiajie; Colbert, Karen N.; Lai, Ying; Pfuetzner, Richard A.; Padolina, Mark S.; Vivona, Sandro; Ressl, Susanne; Cipriano, Daniel J.; Choi, Ucheor B.; Shah, Niket; Weis, William I.; Brunger, Axel T.

Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms Complexin通过不同的机制抑制自发释放并同步Ca2触发的突触小泡融合

ELIFE

IF0

2014-08-13

OAAI

Lai, Ying; Diao, Jiajie; Cipriano, Daniel J.; Zhang, Yunxiang; Pfuetzner, Richard A.; Padolina, Mark S.; Brunger, Axel T.

研究方向