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Discovery and design of molecular glue enhancers of CDK12-DDB1 interactions for targeted degradation of cyclin K 用于靶向降解细胞周期蛋白K的CDK12-DDB1相互作用的分子胶增强剂的发现和设计 Ghosh, Pompom; Schmitz, Maximilian; Pandurangan, Thiyagamurthy; Zeleke, Solomon Tadesse; Chan, Sean Chin; Mosior, John; Sun, Luxin; Palve, Vinayak; Grassie, Dylan; Anand, Kanchan; Frydman, Sylvia; Roush, William R.; Schonbrunn, Ernst; Geyer, Matthias; Duckett, Derek; Monastyrskyi, Andrii 分享 收藏
Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition Shendy, Noha A. M.; Bikowitz, Melissa; Sigua, Logan H.; Zhang, Yang; Mercier, Audrey; Khashana, Yousef; Nance, Stephanie; Liu, Qi; Delahunty, Ian M.; Robinson, Sarah; Goel, Vanshita; Rees, Matthew G.; Ronan, Melissa A.; Wang, Tingjian; Kocak, Mustafa; Roth, Jennifer A.; Wang, Yingzhe; Freeman, Burgess B.; Orr, Brent A.; Abraham, Brian J.; Roussel, Martine F.; Schonbrunn, Ernst; Qi, Jun; Durbin, Adam D. 分享 收藏
Strategies for developing retinoic acid receptor alpha-selective antagonists as novel agents for male contraception Al Noman, Md Abdullah; Cuellar, Rebecca A. D.; Kyzer, Jillian L.; Chung, Sanny S. W.; Cheryala, Narsihmulu; Holth, Trinh A. D.; Maitra, Soma; Naqvi, Tahmina; Wong, Henry L.; Schonbrunn, Ernst; Hawkinson, Jon E.; Wolgemuth, Debra J.; Georg, Gunda I. 分享 收藏
Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding Faber, Erik B.; Sun, Luxin; Tang, Jian; Roberts, Emily; Ganeshkumar, Sornakala; Wang, Nan; Rasmussen, Damien; Majumdar, Abir; Hirsch, Laura E.; John, Kristen; Yang, An; Khalid, Hira; Hawkinson, Jon E.; Levinson, Nicholas M.; Chennathukuzhi, Vargheese; Harki, Daniel A.; Schonbrunn, Ernst; Georg, Gunda I. 分享 收藏
Development of novel JAK2 inhibitors and PROTACs as chemical probes for the investigation of JAK2 inhibition and degradation Humphrey, Briley A.; li, Bao; Ferreira, Renan B.; Ranatunga, Sujeewa R.; Rowsell, Tegan M.; Sun, Luxin; Lawrence, Harshani R.; Schonbrunn, Ernst; Reuther, Gary; Lawrence, Nicholas J. 分享 收藏
Novel autophagy inhibitory strategies to overcome chemotherapy resistance in multiple myeloma Tauro, Marilena; Li, Tao; Meads, Mark; Sudalagunta, Praneeth R.; Alugubelli, Raghunandan R.; Lawrence, Nicholas J.; Schonbrunn, Ernst; Lawrence, Harshani; Shain, Kenneth H.; Lynch, Conor C. 分享 收藏
Discovery of GSTZ1 as a novel target for drug refractory non-small cell lung cancer by using fragment-based chemical proteomics Liao, Yi; Chan, Sean Chin; Welsh, Eric A.; Fang, Bin; Sun, Luxin; Schonbrunn, Ernst; Koomen, John M.; Duckett, Derek R.; Haura, Eric B.; Monastyrskyi, Andrii; Rix, Uwe 分享 收藏
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Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice Faber, Erik B.; Wang, Nan; John, Kristen; Sun, Luxin; Wong, Henry L.; Burban, David; Francis, Rawle; Tian, Defeng; Hong, Kwon H.; Yang, An; Wang, Liming; Elsaid, Mazen; Khalid, Hira; Levinson, Nicholas M.; Schonbrunn, Ernst; Hawkinson, Jon E.; Georg, Gunda I. 分享 收藏
Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione- Dependent Isomerase GSTZ1 as a Lung Cancer Target Liao, Yi; Chan, Sean Chin; Welsh, Eric A.; Fang, Bin; Sun, Luxin; Schonbrunn, Ernst; Koomen, John M.; Duckett, Derek R.; Haura, Eric B.; Monastyrskyi, Andrii; Rix, Uwe 分享 收藏
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EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma Durbin, Adam D.; Wang, Tingjian; Wimalasena, Virangika K.; Zimmerman, Mark W.; Li, Deyao; Dharia, Neekesh, V; Mariani, Luca; Shendy, Noha A. M.; Nance, Stephanie; Patel, Anand G.; Shao, Ying; Mundada, Maya; Maxham, Lily; Park, Paul M. C.; Sigua, Logan H.; Morita, Ken; Conway, Amy Saur; Robichaud, Amanda L.; Perez-Atayde, Antonio R.; Bikowitz, Melissa J.; Quinn, Taylor R.; Wiest, Olaf; Easton, John; Schonbrunn, Ernst; Bulyk, Martha L.; Abraham, Brian J.; Stegmaier, Kimberly; Look, A. Thomas; Qi, Jun 分享 收藏
SARS-CoV-2 Period Seroprevalence and Related Factors, Hillsborough County, Florida, USA, October 2020-March 2021 Giuliano, Anna R.; Pilon-Thomas, Shari; Schell, Michael J.; Abrahamsen, Martha; Islam, Jessica Y.; Isaacs-Soriano, Kimberly; Kennedy, Kayoko; Dukes, Christopher W.; Whiting, Junmin; Rathwell, Julie; Hensel, Jonathan A.; Mangual, Leslie N.; Schonbrunn, Ernst; Bikowitz, Melissa; Grassie, Dylan; Yang, Yan 分享 收藏
Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain Karim, Rezaul Md; Yang, Leixiang; Chen, Lihong; Bikowitz, Melissa J.; Lu, Junhao; Grassie, Dylan; Shultz, Zachary P.; Lopchuk, Justin M.; Chen, Jiandong; Schonbrunn, Ernst 分享 收藏
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Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors Karim, Rezaul Md; Bikowitz, Melissa J.; Chan, Alice; Zhu, Jin-Yi; Grassie, Dylan; Becker, Andreas; Berndt, Norbert; Gunawan, Steven; Lawrence, Nicholas J.; Schonbrunn, Ernst 分享 收藏
New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition Zahid, Huda; Buchholz, Caroline R.; Singh, Manjulata; Ciccone, Michael F.; Chan, Alice; Nithianantham, Stanley; Shi, Ke; Aihara, Hideki; Fischer, Marcus; Schonbrunn, Ernst; dos Santos, Camila O.; Landry, Joseph W.; Pomerantz, William C. K. 分享 收藏
Development of Dimethylisoxazole-Attached Imidazo[1,2-a]pyridines as Potent and Selective CBP/P300 Inhibitors Muthengi, Alex; Wimalasena, Virangika K.; Yosief, Hailemichael O.; Bikowitz, Melissa J.; Sigua, Logan H.; Wang, Tingjian; Li, Deyao; Gaieb, Zied; Dhawan, Gagan; Liu, Shuai; Erickson, Jon; Amaro, Rommie E.; Schonbrunn, Ernst; Qi, Jun; Zhang, Wei 分享 收藏
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