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A

Alison Kurimchak

Fox Chase Cancer Center

H指数:14

被引数:794

个人简介

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教育背景

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工作经历

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Rac1 Selectively Binds a Specific Lamellipodin Isoform via a Noncanonical Helical Interface

Rac1通过一个非经典螺旋界面选择性结合一种特定的Lamellipodin异构体

Journal of Biological Chemistry

IF3.9

2025-12-060

OAAI

KRAS G12V mutation-selective requirement for ACSS2 in colorectal adenoma formation

KRAS G12V突变对ACSS2在结直肠腺瘤形成中的选择性需求

IF6.9

2025-04-010

OAAI

FAM122A ensures cell cycle interphase progression and checkpoint control by inhibiting B55α/PP2A through helical motifs

NATURE COMMUNICATIONS

IF15.7

2024-07-100

OAAI

RAPID resistance to BET inhibitors is mediated by FGFR1 in glioblastoma

SCIENTIFIC REPORTS

IF3.9

2024-04-230

OAAI

Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints

IF7.3

2024-01-192

OA

Kinome profiling identifies MARK3 and STK10 as potential therapeutic targets in uveal melanoma

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2023-12-013

OAAI

Characterizing MEK1/2 degradation in K-ras mutant cells

CANCER RESEARCH

IF16.6

2023-04-040

PRE

Activation of p107 by Fibroblast Growth Factor, Which Is Essential for Chondrocyte Cell Cycle Exit, Is Mediated by the Protein Phosphatase 2A/B55α Holoenzyme

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-2029

OAAI

Extracellular 5'-methylthioadenosine inhibits intracellular symmetric dimethylarginine protein methylation of FUSE-binding proteins

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2022-09-015

OAAI

The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells

药物外排泵MDR1促进癌细胞对PROTACs的内在和获得性耐药

SCIENCE SIGNALING

IF6.6

2022-08-3048

OA

PP2A/B55α substrate recruitment as defined by the retinoblastoma-related protein p107

IF0

2021-10-1818

PRE

Kinome Profiling of Primary Endometrial Tumors Using Multiplexed Inhibitor Beads and Mass Spectrometry Identifies SRPK1 as Candidate Therapeutic Target

MOLECULAR & CELLULAR PROTEOMICS

IF5.5

2020-12-0116

OAAI

Functional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma

SCIENCE SIGNALING

IF6.6

2020-02-1822

OAAI

PPP2R2A prostate cancer haploinsufficiency is associated with worse prognosis and a high vulnerability to B55α/PP2A reconstitution that triggers centrosome destabilization

IF6.4

2019-12-1026

OAAI

Intrinsic Resistance to MEK Inhibition through BET Protein-Mediated Kinome Reprogramming in NF1-Deficient Ovarian Cancer

MOLECULAR CANCER RESEARCH

IF4.7

2019-08-0127

OAAI

Reconstituting B55/protein phosphatase 2A activity in B55/PP2A-defective prostate cancer cells suppresses proliferation and tumorigenicity through pleiotropic mechanisms

CANCER RESEARCH

IF16.6

2017-07-010

PRE

Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer

IF6.9

2016-08-01185

OAAI

Analysis of the tumor suppressor function of B55alpha, the PP2A regulatory subunit encoded by PPP2R2A, in prostate cancer cells

CANCER RESEARCH

IF16.6

2016-07-151

PRE

PP2A: more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues

IF3.4

2014-11-1837

OAAI

B55α PP2A Holoenzymes Modulate the Phosphorylation Status of the Retinoblastoma-related Protein p107 and Its Activation

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2010-09-0146

OAAI