未登录 PNPLA3-I148M genetic variant rewires lipid metabolism to drive programmed cell death in human hepatocytes PNPLA3-I148M基因变异重编程脂质代谢，驱动人肝细胞程序性死亡。 Florentino, Rodrigo M.; Animasahun, Olamide; Haep, Nils; Nenwani, Minal; Omoloja, Kehinde; Altay, Leyla Nurcihan; Achreja, Abhinav; Morita, Kazutoyo; Motomura, Takashi; Diaz-Aragon, Ricardo; Faccioli, Lanuza A. P.; Sun, Yiyue; Liu, Zhenghao; Hu, Zhiping; Yang, Bo; Wuchu, Fulei; Shankaran, Ajay; Paserba, Miya; Baratta, Annalisa M.; Arazov, Shohrat; Kocas-Kilicarslan, Zehra N.; Meurs, Noah; Behari, Jaideep; Tafaleng, Edgar N.; Franks, Jonathan; Ostrowska, Alina; Tomiyama, Takahiro; Yugawa, Kyohei; Morinaga, Akinari; Wang, Zi; Takeishi, Kazuki; Gavlock, Dillon C.; Miedel, Mark; Taylor, D. Lansing; Fox, Ira J.; Yoshizumi, Tomoharu; Nagrath, Deepak; Soto-Gutierrez, Alejandro 分享 收藏
A metabolic dysfunction-associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system 代谢功能障碍相关的脂肪性肝腺泡仿生在耦合的微生理学系统中诱导胰岛功能障碍 Aleman, Julio; Ravikumar, K.; Wiegand, Connor; Schurdak, Mark E.; Vernetti, Lawrence; Gavlock, Dillon; Reese, Celeste; DeBiasio, Richard; LaRocca, Greg; Angarita, Yulder Daniel; Gough, Albert; Soto-Gutierrez, Alejandro; Behari, Jaideep; Yechoor, Vijay K.; Miedel, Mark T.; Stern, Andrew M.; Banerjee, Ipsita; Taylor, D. Lansing 分享 收藏
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis (vol 10, 3126, 2019) Argemi, Josepmaria; Latasa, Maria U.; Atkinson, Stephen R.; Blokhin, Ilya O.; Massey, Veronica; Gue, Joel P.; Cabezas, Joaquin; Lozano, Juan J.; Van Booven, Derek; Bell, Aaron; Cao, Sheng; Vernetti, Lawrence A.; Arab, Juan P.; Ventura-Cots, Meritxell; Edmunds, Lia R.; Fondevila, Constantino; Starkel, Peter; Dubuquoy, Laurent; Louvet, Alexandre; Odena, Gemma; Gomez, Juan L.; Aragon, Tomas; Altamirano, Jose; Caballeria, Juan; Jurczak, Michael J.; Taylor, D. Lansing; Berasain, Carmen; Wahlestedt, Claes; Monga, Satdarshan P.; Morgan, Marsha Y.; Sancho-Bru, Pau; Mathurin, Philippe; Furuya, Shinji; Lackner, Carolin; Rusyn, Ivan; Shah, Vijay H.; Thursz, Mark R.; Mann, Jelena; Avila, Matias A.; Bataller, Ramon 分享 收藏
Modeling mechanisms underlying differential inflammatory responses to COVID-19 in type 2 diabetes using a patient-derived microphysiological organ-on-a-chip system Negi, Vinny; Gavlock, Dillon; Miedel, Mark T.; Lee, Jeong Kyung; Shun, Tongying; Gough, Albert; Vernetti, Lawrence; Stern, Andrew M.; Taylor, D. Lansing; Yechoor, Vijay K. 分享 收藏
A Quantitative Systems Pharmacology Platform Reveals NAFLD Pathophysiological States and Targeting Strategies Lefever, Daniel E.; Miedel, Mark T.; Pei, Fen; DiStefano, Johanna K.; Debiasio, Richard; Shun, Tong Ying; Saydmohammed, Manush; Chikina, Maria; Vernetti, Lawrence A.; Soto-Gutierrez, Alejandro; Monga, Satdarshan P.; Bataller, Ramon; Behari, Jaideep; Yechoor, Vijay K.; Bahar, Ivet; Gough, Albert; Stern, Andrew M.; Taylor, D. Lansing 分享 收藏
Biomanufacturing in low Earth orbit for regenerative medicine Sharma, Arun; Clemens, Rachel A.; Garcia, Orquidea; Taylor, D. Lansing; Wagner, Nicole L.; Shepard, Kelly A.; Gupta, Anjali; Malany, Siobhan; Grodzinsky, Alan J.; Kearns-Jonker, Mary; Mair, Devin B.; Kim, Deok-Ho; Roberts, Michael S.; Loring, Jeanne F.; Hu, Jianying; Warren, Lara E.; Eenmaa, Sven; Bozada, Joe; Paljug, Eric; Roth, Mark; Taylor, Donald P.; Rodrigue, Gary; Cantini, Patrick; Smith, Amelia W.; Giulianotti, Marc A.; Wagner, William R. 分享 收藏
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A systems-level study reveals host-targeted repurposable drugs against SARS-CoV-2 infection Chen, Fangyuan; Shi, Qingya; Pei, Fen; Vogt, Andreas; Porritt, Rebecca A.; Garcia Jr, Gustavo; Gomez, Angela C.; Cheng, Mary Hongying; Schurdak, Mark E.; Liu, Bing; Chan, Stephen Y.; Arumugaswami, Vaithilingaraja; Stern, Andrew M.; Taylor, D. Lansing; Arditi, Moshe; Bahar, Ivet 分享 收藏
Analysis of reproducibility and robustness of a human microfluidic four-cell liver acinus microphysiology system (LAMPS) Sakolish, Courtney; Reese, Celeste E.; Luo, Yu-Syuan; Valdiviezo, Alan; Schurdak, Mark E.; Gough, Albert; Taylor, D. Lansing; Chiu, Weihsueh A.; Vernetti, Lawrence A.; Rusyn, Ivan 分享 收藏
Paths to Successful Translation of New Therapies for Severe Traumatic Brain Injury in the Golden Age of Traumatic Brain Injury Research: A Pittsburgh Vision 在创伤性脑损伤研究的黄金时代，成功翻译严重创伤性脑损伤的新疗法的途径: 匹兹堡的愿景 Kochanek, Patrick M.; Jackson, Travis C.; Jha, Ruchira M.; Clark, Robert S. B.; Okonkwo, David O.; Bayir, Hulya; Poloyac, Samuel M.; Wagner, Amy K.; Empey, Philip E.; Conley, Yvette P.; Bell, Michael J.; Kline, Anthony E.; Bondi, Corina O.; Simon, Dennis W.; Carlson, Shaun W.; Puccio, Ava M.; Horvat, Christopher M.; Au, Alicia K.; Elmer, Jonathan; Treble-Barna, Amery; Ikonomovic, Milos D.; Shutter, Lori A.; Taylor, D. Lansing; Stern, Andrew M.; Graham, Steven H.; Kagan, Valerian E.; Jackson, Edwin K.; Wisniewski, Stephen R.; Dixon, C. Edward 分享 收藏
Spatial domain analysis predicts risk of colorectal cancer recurrence and infers associated tumor microenvironment networks Uttam, Shikhar; Stern, Andrew M.; Sevinsky, Christopher J.; Furman, Samantha; Pullara, Filippo; Spagnolo, Daniel; Nguyen, Luong; Gough, Albert; Ginty, Fiona; Lansing Taylor, D.; Chakra Chennubhotla, S. 分享 收藏
Targeting NAD+ Biosynthesis Overcomes Panobinostat and Bortezomib-Induced Malignant Glioma Resistance Jane, Esther P.; Premkumar, Daniel R.; Thambireddy, Swetha; Golbourn, Brian; Agnihotri, Sameer; Bertrand, Kelsey C.; Mack, Stephen C.; Myers, Max I.; Chattopadhyay, Ansuman; Taylor, D. Lansing; Schurdak, Mark E.; Stern, Andrew M.; Pollack, Ian F. 分享 收藏
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Improving natural product research translation: From source to clinical trial Sorkin, Barbara C.; Kuszak, Adam J.; Bloss, Gregory; Fukagawa, Naomi K.; Hoffman, Freddie Ann; Jafari, Mahtab; Barrett, Bruce; Brown, Paula N.; Bushman, Frederic D.; Casper, Steven J.; Chilton, Floyd H.; Coffey, Christopher S.; Ferruzzi, Mario G.; Hopp, D. Craig; Kiely, Mairead; Lakens, Daniel; MacMillan, John B.; Meltzer, David O.; Pahor, Marco; Paul, Jeffrey; Pritchett-Corning, Kathleen; Quinney, Sara K.; Rehermann, Barbara; Setchell, Kenneth D. R.; Sipes, Nisha S.; Stephens, Jacqueline M.; Taylor, D. Lansing; Tiriac, Herve; Walters, Michael A.; Xi, Dan; Zappala, Giovanna; Pauli, Guido F. 分享 收藏
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis HNF4alpha-dependent基因表达缺陷是酒精性肝炎肝细胞衰竭的驱动因素 Argemie, Josepmaria; Latasa, Maria U.; Atkinson, Stephen R.; Blokhin, Ilya O.; Massey, Veronica; Gue, Joel P.; Cabezas, Joaquin; Lozano, Juan J.; Van Booven, Derek; Bell, Aaron; Cao, Sheng; Vernetti, Lawrence A.; Arab, Juan P.; Ventura-Cots, Meritxell; Edmunds, Lia R.; Fondevilla, Constantino; Starkel, Peter; Dubuquoy, Laurent; Louvet, Alexandre; Odena, Gemma; Gomez, Juan L.; Aragon, Tomas; Altamirano, Jose; Caballeria, Juan; Jurczak, Michael J.; Taylor, D. Lansing; Berasain, Carmen; Wahlestedt, Claes; Mongv, Satdarshan P.; Morgan, Marsha Y.; Sancho-Bru, Pau; Mathurin, Philippe; Furuya, Shinji; Lackner, Carolin; Rusyn, Ivan; Shah, Vijay H.; Thursz, Mark R.; Mann, Jelena; Avila, Matias A.; Bataller, Ramon 分享 收藏
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Gene signatures identify quinolate phosphoribosyltransferase as a key mediator of acquired resistance to Panobinostat and Bortezomib in glioma, and NAD plus biosynthesis as a targetable pathway to reverse treatment resistance Jane, Esther P.; Premkumar, Daniel R.; Agnihotri, Sameer; Myers, Max; Chattopadhyay, Ansuman; Taylor, D. Lansing; Schurdak, Mark; Stern, Andrew; Pollack, Ian F. 分享 收藏
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Opportunities and Challenges in Implementation of Multiparameter Single Cell Analysis Platforms for Clinical Translation 用于临床翻译的多参数单细胞分析平台实施的机遇和挑战 Keating, Susan M.; Taylor, D. Lansing; Plant, Anne L.; Litwack, E. David; Kuhn, Peter; Greenspan, Emily J.; Hartshorn, Christopher M.; Sigman, Caroline C.; Kelloff, Gary J.; Chang, David D.; Friberg, Gregory; Lee, Jerry S. H.; Kuida, Keisuke 分享 收藏
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