未登录 USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF Jurisic, Anamarija; Sung, Pei-Ju; Wappett, Mark; Daubriac, Julien; Lobb, Ian T.; Kung, Wei-Wei; Crawford, Nyree; Page, Natalie; Cassidy, Eamon; Feutren-Burton, Stephanie; Rountree, J. S. Shane; Helm, Matthew D.; O'Dowd, Colin R.; Kennedy, Richard D.; Gavory, Gerald; Cranston, Aaron N.; Longley, Daniel B.; Jacq, Xavier; Harrison, Timothy 分享 收藏
A novel first-in-class USP19 inhibitor for the treatment of cancer-induced muscle atrophy Page, Natalie; Karthikaisamy, Vignesh; O'Hara, Darren; Cranston, Aaron N.; O'Dowd, Colin R.; Jacq, Xavier; Wilkinson, Richard; Burton, Stephanie; Gibson, Hayley; Costa, Joana; Longley, Daniel; Helm, Matthew; McGivern, Chris; Shepherd, Steven; Bell, Christina; Hewitt, Peter; McFarland, Mary; Miel, Hugues; Whitehead, Steven; Proctor, Lauren; Rountree, Shane J.; Wappett, Mark; Diaz, Mauricio Berriel; Herzig, Stephan; Harrison, Timothy 分享 收藏
RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer Khawaja, Hajrah; Campbell, Andrew; Roberts, Jamie Z.; Javadi, Arman; O'Reilly, Paul; McArt, Darragh; Allen, Wendy L.; Majkut, Joanna; Rehm, Markus; Bardelli, Alberto; Di Nicolantonio, Federica; Scott, Christopher J.; Kennedy, Richard; Vitale, Nicolas; Harrison, Timothy; Sansom, Owen J.; Longley, Daniel B.; Evergren, Emma; Van Schaeybroeck, Sandra 分享 收藏
A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis Humphreys, Luke M.; Fox, Jennifer P.; Higgins, Catherine A.; Majkut, Joanna; Sessler, Tamas; McLaughlin, Kirsty; McCann, Christopher; Roberts, Jamie Z.; Crawford, Nyree T.; McDade, Simon S.; Scott, Christopher J.; Harrison, Timothy; Longley, Daniel B. 分享 收藏
Development and pre-clinical assessment of a first-in-class small molecule inhibitor of FLIP Higgins, Catherine A.; Fox, Jennifer; Majkut, Joanna; Fiedler, Greti E.; Roberts, Jamie; Humphreys, Luke; Boffey, Ray J.; Perrior, Trevor R.; Harrison, Timothy; Longley, Daniel B. 分享 收藏
FKBPL as a novel therapeutic target and prognostic biomarker in high grade serous ovarian cancer Annett, Stephanie; Moore, Gillian; Short, Amy; Moustafa, Neermeen; Das, Sudipto; O'Connor, Darran; McCrudden, Cian; Kissenpfenning, Adrien; Nelson, Laura; Harley, Ian; Arthur, Ken; Yakkundi, Anita; McCluggage, Glen; Marshall, Andrea; Furlong, Fiona; McCarthy, Helen O.; Cotton, Graham; Harrison, Timothy; McClements, Lana; Robson, Tracy 分享 收藏
Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors 基于嘧啶酮的USP7抑制剂的鉴定和结构指导开发 O'Dowd, Colin R.; Helm, Matthew D.; Rountree, J. S. Shane; Flasz, Jakub T.; Arkoudis, Elias; Miel, Hugues; Hewitt, Peter R.; Jordan, Linda; Barker, Oliver; Hughes, Caroline; Rozycka, Ewelina; Cassidy, Eamon; McClelland, Keeva; Odrzywol, Ewa; Page, Natalie; Feutren-Burton, Stephanie; Dvorkin, Scarlett; Gavory, Gerald; Harrison, Timothy 分享 收藏
Development and preclinical assessment of a first-in-class small-molecule inhibitor of FLIP Higgins, Catherine A.; Majkut, Joanna; Fox, Jennifer; Humphreys, Luke; Fiedler, Greti Espona; Boffey, Ray J.; Perrior, Trevor R.; Haigh, David; Harrison, Timothy; Longley, Daniel B. 分享 收藏
Discovery and characterization of highly potent and selective allosteric USP7 inhibitors Gavory, Gerald; O'Dowd, Colin R.; Helm, Matthew D.; Flasz, Jakub; Arkoudis, Elias; Dossang, Anthony; Hughes, Caroline; Cassidy, Eamon; McClelland, Keeva; Odrzywol, Ewa; Page, Natalie; Barker, Oliver; Miel, Hugues; Harrison, Timothy 分享 收藏
Identification and Characterization of Dual Inhibitors of the USP25/28 Deubiquitinating Enzyme Subfamily Wrigley, Jonathan D.; Gavory, Gerald; Simpson, Iain; Preston, Marian; Plant, Helen; Bradley, Jenna; Goeppert, Anne U.; Rozycka, Ewelina; Davies, Gareth; Walsh, Jarrod; Valentine, Andrea; McClelland, Keeva; Odrzywol, Krzysztofa Ewa; Renshaw, Jonathan; Boros, Joanna; Tart, Jonathan; Leach, Lindsey; Nowak, Thorsten; Ward, Richard A.; Harrison, Timothy; Andrews, David M. 分享 收藏
分享 收藏
FLIP: A Targetable Mediator of Resistance to Radiation in Non-Small Cell Lung Cancer McLaughlin, Kylie A.; Nemeth, Zsuzsanna; Bradley, Conor A.; Humphreys, Luke; Stasik, Izabela; Fenning, Catherine; Majkut, Joanna; Higgins, Catherine; Crawford, Nyree; Holohan, Caitriona; Johnston, Patrick G.; Harrison, Timothy; Hanna, Gerard G.; Butterworth, Karl T.; Prise, Kevin M.; Longley, Daniel B. 分享 收藏
A biomarker-guided first-in-human trial of subcutaneous ALM201 in patients with solid tumours El-Helali, A.; Plummer, R.; Jayson, G.; Coyle, V.; Rogers, C.; D'Arcangelo, M.; Graham, M.; Drew, Y.; Clamp, A.; McCann, J.; McCavigan, A.; Knight, L.; McCabe, N.; Keating, K.; Dyer, R.; Harrison, T.; Harkin, P.; Robson, T.; Kennedy, R.; Wilson, R. 分享 收藏
Delivering a research-enabled multistakeholder partnership for enhanced patient care at a population level: The Northern Ireland Comprehensive Cancer Program Lawler, Mark; Gavin, Anna; Salto-Tellez, Manuel; Kennedy, Richard D.; Van Schaeybroeck, Sandra; Wilson, Richard H.; Harkin, Denis Paul; Grayson, Margaret; Boyd, Ruth E.; Hamilton, Peter W.; McArt, Darragh G.; James, Jacqueline; Robson, Tracy; Ladner, Robert D.; Prise, Kevin M.; O'Sullivan, Joe M.; Harrison, Timothy; Murray, Liam; Johnston, Patrick G.; Waugh, David J. 分享 收藏
Development and preclinical assessment of a first-in-class small molecule inhibitor of the major cell death regulator protein FLIP Majkut, Joanna; Higgins, Catherine; Maliki, Adnan; Nemeth, Zsusannah; Blurton, Peter; Boffey, Ray; Perrior, Trevor R.; Johnston, Patrick G.; Haigh, David; Harrison, Timothy; Longley, Daniel B. 分享 收藏
The critical requirement of ATM function in PTEN null cell lines McCabe, Nuala; Walker, Steven M.; Greenan, Caroline; Wikstrom, Katarina; McLean, Estelle; Delaney, Thomas; McCarthy, Michelle; James, Iain; Harrison, Timothy; Mullan, Paul; Harkin, Paul; Kennedy, Richard 分享 收藏
分享 收藏
7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine:: A functionally selective γ-aminobutyric acidA (GABAA) α2/α3-subtype selective agonist that exhibits potent anxiolytic activity but is not sedating in animal models Carling, RW; Madin, A; Guiblin, A; Russell, MGN; Moore, KW; Mitchinson, A; Sohal, B; Pike, A; Cook, SM; Ragan, IC; McKernan, RM; Quirk, K; Ferris, P; Marshall, G; Thompson, SA; Wafford, KA; Dawson, GR; Atack, JR; Harrison, T; Castro, JL; Street, LJ 分享 收藏
Design and synthesis of highly potent benzodiazepine γ-secretase inhibitors:: Preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4-hydroxy-N-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]- diazepin-3-yl)butyramide by use of an asymmetric Ireland-Claisen rearrangement Churcher, I; Williams, S; Kerrad, S; Harrison, T; Castro, JL; Shearman, MS; Lewis, HD; Clarke, EE; Wrigley, JDJ; Beher, D; Tang, YS; Liu, WS 分享 收藏
New synthesis of 1,3-dihydro-1,4-benzodiazepin-2(2H)-ones and 3-amino-1,3-dihydro-1,4-benzodiazepin-2(2H)-ones:: Pd-catalyzed cross-coupling of imidoyl chlorides with organoboronic acids Nadin, A; López, JMS; Owens, AP; Howells, DM; Talbot, AC; Harrison, T 分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
