Joseph M. Hayes - Publications, H-index & Citations

Joseph M. Hayes

University of Lancashire

35H指数

162论文数

3.7K被引数

收录论文 43

发表时间

In silico screening for CDK5 inhibitors leads to SAR analysis of flavonoids, three diverse inhibitor scaffolds and fisetin demonstrating potent in vitro glioblastoma effects 基于计算机的CDK5抑制剂筛选导致黄酮类化合物构效关系分析、三种多样化抑制剂骨架以及木犀草素显示出强大的体外胶质母细胞瘤效应

Journal of Molecular Structure

IF4.7

2026-09-15

OAAI

Zahra R. Khan; Philip J. Welsby; Izabela Stasik; Joseph M. Hayes

REGULATION OF GLYCOGEN METABOLISM AS A POTENTIAL THERAPEUTIC APPROACH AGAINST GLIOBLASTOMA 糖原代谢的调控作为一种潜在的治疗胶质母细胞瘤的方法

Neuro-Oncology

IF13.4

2025-09-02

OAAI

Niah Schram; Joseph Hayes; Tamara Zwain

Evidence for the Quercetin Binding Site of Glycogen Phosphorylase as a Target for Liver-Isoform-Selective Inhibitors against Glioblastoma: Investigation of Flavanols Epigallocatechin Gallate and Epigallocatechin

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

IF6.2

2024-10-21

OAAI

Alexopoulos, Serafeim; McGawley, Megan; Mathews, Roshini; Papakostopoulou, Souzana; Koulas, Symeon; Leonidas, Demetres D.; Zwain, Tamara; Hayes, Joseph M.; Skamnaki, Vasiliki

Discovery of Potent Multikinase Type-II Inhibitors Targeting CDK5 in the DFG-out Inactive State with Promising Potential against Glioblastoma

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-04-30

PREAI

Khan, Zahra R.; Welsby, Philip J.; Stasik, Izabela; Hayes, Joseph M.

In Silico-Motivated Discovery of Novel Potent Glycogen Synthase-3 Inhibitors: 1-(Alkyl/arylamino)-3H-naphtho[1,2,3-de]quinoline-2,7-dione Identified as a Scaffold for Kinase Inhibitor Development

PHARMACEUTICALS

IF4.8

2023-04-28

OAAI

Emmerich, Thomas D.; Hayes, Joseph M.

Design and Synthesis of 3-(β-D-Glucopyranosyl)-4-amino/4-guanidino Pyrazole Derivatives and Analysis of Their Glycogen Phosphorylase Inhibitory Potential

MOLECULES

IF4.6

2023-03-28

OAAI

Kun, Sandor; Mathomes, Rachel T.; Docsa, Tibor; Somsak, Laszlo; Hayes, Joseph M.

Novel diarylamides and diarylureas with N-substitution dependent activity against medulloblastoma

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2021-12-01

OAAI

Lawson, Christopher; Alta, Thowaiba Babikr Ahmed; Moschou, Georgia; Skamnaki, Vasiliki; Solovou, Theodora G. A.; Topham, Caroline; Hayes, Joseph; Snape, Timothy J.

Nanomolar inhibition of human OGA by 2-acetamido-2-deoxy-D-glucono-1,5-lactone semicarbazone derivatives

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2021-11-01

OAAI

Kiss, Mariann; Szabo, Erna; Bocska, Boglarka; Sinh, Luu Thanh; Fernandes, Conceicao Piedade; Timari, Istvan; Hayes, Joseph M.; Somsak, Laszlo; Barna, Terez

Structure-Based Design of Potent Selective Nanomolar Type-II Inhibitors of Glycogen Synthase Kinase-3β

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-01-27

OAAI

Davies, Matthew P.; Benitez, Rocio; Perez, Concepcion; Jakupovic, Sven; Welsby, Philip; Rzepecka, Klaudia; Alder, Jane; Davidson, Colin; Martinez, Ana; Hayes, Joseph M.

Aromatic Stacking Facilitated Self-Assembly of Ultrashort Ionic Complementary Peptide Sequence: β-Sheet Nanofibers with Remarkable Gelation and Interfacial Properties

BIOMACROMOLECULES

IF5.4

2020-05-13

OAAI

Wychowaniec, Jacek K.; Patel, Ronak; Leach, James; Mathomes, Rachel; Chhabria, Vikesh; Patil-Sen, Yogita; Hidalgo-Bastida, Araida; Forbes, Robert T.; Hayes, Joseph M.; Elsawy, Mohamed A.

Identification of C-β-D-Glucopyranosyl Azole-Type Inhibitors of Glycogen Phosphorylase That Reduce Glycogenolysis in Hepatocytes: In Silico Design, Synthesis, in Vitro Kinetics, and ex Vivo Studies 鉴定减少肝细胞糖原分解的糖原磷酸化酶的c-β-d-吡喃葡萄糖基唑型抑制剂: 计算机设计，合成，体外动力学和离体研究

ACS CHEMICAL BIOLOGY

IF3.8

2019-06-03

OAAI

Barr, Daniel; Szennyes, Eszter; Bokor, Eva; Al-Oanzi, Ziad H.; Moffatt, Colin; Kun, Sandor; Docsa, Tibor; Sipos, Adam; Davies, Matthew P.; Mathomes, Rachel T.; Snape, Timothy J.; Agius, Loranne; Somsak, Laszlo; Hayes, Joseph M.

A multidisciplinary study of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: Computation, synthesis, crystallography and kinetics reveal new potent inhibitors

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2018-03-01

OAAI

Kun, Sandor; Begum, Jaida; Kyriakis, Efthimios; Stamati, Evgenia C. V.; Barkas, Thomas A.; Szennyes, Eszter; Bokor, Eva; Szabo, Katalin E.; Stravodimos, George A.; Sipos, Adam; Docsa, Tibor; Gergely, Pal; Moffatt, Colin; Patraskaki, Myrto S.; Kokolaki, Maria C.; Gkerdi, Alkistis; Skamnaki, Vassiliki T.; Leonidas, Demetres D.; Somsak, Laszlo; Hayes, Joseph M.

Evidence for Novel Action at the Cell-Binding Site of Human Angiogenin Revealed by Heteronuclear NMR Spectroscopy, insilico and invivo Studies

CHEMMEDCHEM

IF3.4

2018-01-15

OAAI

Chatzileontiadou, Demetra S. M.; Tsika, Aikaterini C.; Diamantopoulou, Zoi; Delbe, Jean; Badet, Josette; Courty, Jose; Skamnaki, Vassiliki T.; Parmenopoulou, Vanessa; Komiotis, Dimitri; Hayes, Joseph M.; Spyroulias, Georgios A.; Leonidas, Demetres D.

The triterpene echinocystic acid and its 3-O-glucoside derivative are revealed as potent and selective glucocorticoid receptor agonists

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

IF2.8

2016-10-01

OAAI

Georgatza, Demetra; Gorgogietas, Vyron A.; Kylindri, Paraskevi; Charalambous, Maria Ch.; Papadopoulou, Kalliope K.; Hayes, Joseph M.; Psarra, Anna-Maria G.

Ketone Hydrogenation with Iridium Complexes with non N-H Ligands: The Key Role of the Strong Base

ACS CATALYSIS

IF13.1

2015-06-18

OAAI

Hayes, Joseph M.; Deydier, Eric; Ujaque, Gregori; Lledos, Agusti; Malacea-Kabbara, Raluca; Manoury, Eric; Vincendeau, Sandrine; Poli, Rinaldo

Structure based inhibitor design targeting glycogen phosphorylase b. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-β-D-glucopyranosylamines 以糖原磷酸化酶b为靶点的基于结构的抑制剂设计。新型N-酰基-β-d-吡喃葡萄糖基胺的虚拟筛选、合成、生化及生物学评价

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2014-09-01

OAAI

Parmenopoulou, Vanessa; Kantsadi, Anastassia L.; Tsirkone, Vicky G.; Chatzileontiadou, Demetra S. M.; Manta, Stella; Zographos, Spyros E.; Molfeta, Christina; Archontis, Georgios; Agius, Loranne; Hayes, Joseph M.; Leonidas, Demetres D.; Komiotis, Dimitri

Natural products and their derivatives as inhibitors of glycogen phosphorylase: potential treatment for type 2 diabetes

PHYTOCHEMISTRY REVIEWS

IF7.6

2014-05-18

PREAI

Hayes, Joseph M.; Kantsadi, Anastassia L.; Leonidas, Demetres D.

Sourcing the affinity of flavonoids for the glycogen phosphorylase inhibitor site via crystallography, kinetics and QM/MM-PBSA binding studies: Comparison of chrysin and flavopiridol

FOOD AND CHEMICAL TOXICOLOGY

IF3.5

2013-11-01

PREAI

Tsitsanou, Katerina E.; Hayes, Joseph M.; Keramioti, Maria; Mamais, Michalis; Oikonomakos, Nikos G.; Kato, Atsushi; Leonidas, Demetres D.; Zographos, Spyros E.

Synthesis, enzyme kinetics and computational evaluation of N-(β-D-glucopyranosyl) oxadiazolecarboxamides as glycogen phosphorylase inhibitors

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2013-09-01

OAAI

Polyak, Maria; Varga, Gergely; Szilagyi, Bence; Juhasz, Laszlo; Docsa, Tibor; Gergely, Pal; Begum, Jaida; Hayes, Joseph M.; Somsak, Laszlo

WAGE AND MOBILITY EFFECTS OF LEGALIZATION: EVIDENCE FROM THE NEW IMMIGRANT SURVEY

JOURNAL OF REGIONAL SCIENCE

IF2.7

2012-10-28

PREAI

Lofstrom, Magnus; Hill, Laura; Hayes, Joseph

研究方向