未登录

P

Panpan Hou

Chinese Medicine

H指数:16

被引数:831

个人简介

暂无内容

教育背景

暂无内容

工作经历

暂无内容

荣誉奖项

暂无内容

Secondary structure transitions and dual PIP2 binding define cardiac KCNQ1-KCNE1 channel gating

二级结构转变和双PIP2结合定义了心脏KCNQ1-KCNE1通道的门控机制

IF25.9

2025-10-020

OA

Impaired inflammatory resolution with severe SARS-CoV-2 infection in leptin knock out obese hamster

瘦素敲除肥胖仓鼠中严重SARS-CoV-2感染导致的炎症消退障碍

IF4.1

2025-02-010

OAAI

Small molecule inhibits KCNQ channels with a non-blocking mechanism

小分子通过非阻断机制抑制KCNQ通道

NATURE CHEMICAL BIOLOGY

IF13.7

2025-01-150

PRE

The fully activated open state of KCNQ1 controls the cardiac fight-or-flight response

KCNQ1的完全激活开放状态控制心脏搏斗或逃跑反应

IF3.8

2024-10-090

OAAI

Targeting the IKs Channel PKA Phosphorylation Axis to Restore Its Function in High-Risk LQT1 Variants

CIRCULATION RESEARCH

IF16.2

2024-09-130

PRE

A small-molecule activation mechanism that directly opens the KCNQ2 channel

NATURE CHEMICAL BIOLOGY

IF13.7

2024-01-025

PRE

Chinese herbal medicine for the treatment of cardiovascular diseases - Targeting cardiac ion channels

PHARMACOLOGICAL RESEARCH

IF10.5

2023-06-016

OAAI

A PIP2 substitute mediates voltage sensor-pore coupling in KCNQ activation (July ,10.1038/s42003-020-1104-0, 2020)

COMMUNICATIONS BIOLOGY

IF5.1

2022-12-210

OAAI

Structural mechanisms for the activation of human cardiac KCNQ1 channel by electro-mechanical coupling enhancers

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2022-11-0315

OAAI

A benzodiazepine activator locks Kv7.1 channels open by electro-mechanical uncoupling

COMMUNICATIONS BIOLOGY

IF5.1

2022-04-018

OAAI

Editorial: Ion Channels: Therapeutic Targets for Neurological Disease

FRONTIERS IN MOLECULAR NEUROSCIENCE

IF3.8

2021-11-161

OAAI

Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2021-05-148

OA

A PIP2 substitute mediates voltage sensor-pore coupling in KCNQ activation

COMMUNICATIONS BIOLOGY

IF5.1

2020-07-1626

OAAI

Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state

IF0

2020-02-2538

OA

Two-stage electro-mechanical coupling of a KV channel in voltage-dependent activation

NATURE COMMUNICATIONS

IF15.7

2020-02-0341

OAAI

ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling

IF0

2019-07-2228

OA

Predicting Patient Response to the Antiarrhythmic Mexiletine Based on Genetic Variation Personalized Medicine for Long QT Syndrome

CIRCULATION RESEARCH

IF16.2

2019-02-1547

OAAI

CP1 Is a Potent IKs Channel Activator Which Acts by Substituting Phosphatidylinositol 4,5 Bisphosphate

BIOPHYSICAL JOURNAL

IF3.1

2019-02-010

OAAI

Structure of the Intermediate State of the Human KCNQ1 Channel Voltage-Sensor Domain

BIOPHYSICAL JOURNAL

IF3.1

2019-02-010

OAAI

A Non-Canonical VSD-Pore Coupling in KCNQ Channels

BIOPHYSICAL JOURNAL

IF3.1

2019-02-010

OAAI