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A

Alexander G. Sorets

Vanderbilt University
H指数:8
被引数:434

个人简介

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工作经历

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荣誉奖项

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Intravenous lipid-siRNA conjugate mediates gene silencing at the blood-brain barrier and blood-CSF barrier

静脉注射脂质-siRNA缀合物在血脑屏障和血-脑脊液屏障介导基因沉默

Journal of Controlled Release
IF11.5
2025-09-110
OA
Alexander G. Sorets; Katrina R. Schwensen; Nora Francini; Andrew Kjar; Sarah Lyons; Joshua C. Park; Dillon Palmer; Adam M. Abdulrahman; Rebecca P. Cowell; Ketaki A. Katdare; Ella N. Hoogenboezem; Angela Wang; Alexander P. Ligocki; Rebecca J. Embalabala; Neil Dani; Craig L. Duvall; Ethan S. Lippmann
Elucidating brain transport pathways and cell type-dependent gene silencing of a durable lipid-siRNA conjugate administered into cerebrospinal fluid

阐明一种耐用的脂质-siRNA缀合物经脑脊液给药后的脑内转运途径及细胞类型依赖性基因沉默

NUCLEIC ACIDS RESEARCH
IF13.1
2025-07-082
OAAI
Sorets, Alexander G.; Schwensen, Katrina R.; Francini, Nora; Kjar, Andrew; Abdulrahman, Adam M.; Shostak, Alena; Katdare, Ketaki A.; Schoch, Kathleen M.; Cowell, Rebecca P.; Park, Joshua C.; Ligocki, Alexander P.; Ford, William T.; Ventura-Antunes, Lissa; Hoogenboezem, Ella N.; Prusky, Alex; Castleberry, Mark; Michell, Danielle L.; Fritsch, Emma; Lyons, Sarah M.; Miller, Timothy M.; Vickers, Kasey C.; Schrag, Matthew S.; Duvall, Craig L.; Lippmann, Ethan S.
siRNA conjugate with high albumin affinity and degradation resistance for delivery and treatment of arthritis in mice and guinea pigs

具有高白蛋白亲和力和降解抵抗性的siRNA缀合物，用于小鼠和大鼠的关节炎递送与治疗

NATURE BIOMEDICAL ENGINEERING
IF26.6
2025-05-160
OA
Colazo, Juan M.; Keech, Megan C.; Shah, Veeraj; Hoogenboezem, Ella N.; Lo, Justin H.; Francini, Nora; Cassidy, Nina T.; Yu, Fang; Sorets, Alexander G.; Mccune, Joshua T.; Dejulius, Carlisle R.; Cho, Hongsik; Michell, Danielle L.; Vickers, Kacey C.; Gibson-Corley, Katherine N.; Hasty, Karen A.; Crofford, Leslie J.; Cook, Rebecca S.; Duvall, Craig L.
IQGAP2 regulates blood-brain barrier immune dynamics

IQGAP2调节血脑屏障免疫动力学

ISCIENCE
IF4.1
2025-03-010
OAAI
Katdare, Ketaki A.; Kjar, Andrew; O'Brown, Natasha M.; Neal, Emma H.; Sorets, Alexander G.; Shostak, Alena; Romero-Fernandez, Wilber; Kwiatkowski, Alexander J.; Mlouk, Kate; Kim, Hyosung; Cowell, Rebecca P.; Schwensen, Katrina R.; Tapia, Cristian O. Carvajal; Venslovaite, Guste; Horner, Kensley B.; Wilson, John T.; Schrag, Matthew S.; Megason, Sean G.; Lippmann, Ethan S.
Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin

反应性星形胶质细胞通过TNF-STAT3信号轴和 α1-抗胰凝乳蛋白酶的分泌在血脑屏障模型中转导炎症

NATURE COMMUNICATIONS
IF15.7
2022-11-0262
OAAI
Kim, Hyosung; Leng, Kun; Park, Jinhee; Sorets, Alexander G.; Kim, Suil; Shostak, Alena; Embalabala, Rebecca J.; Mlouk, Kate; Katdare, Ketaki A.; Rose, Indigo V. L.; Sturgeon, Sarah M.; Neal, Emma H.; Ao, Yan; Wang, Shinong; Sofroniew, Michael, V; Brunger, Jonathan M.; McMahon, Douglas G.; Schrag, Matthew S.; Kampmann, Martin; Lippmann, Ethan S.

研究方向

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E
Ethan S. Lippmann
H 指数:26论文数:126被引数:4,311
N
Nora Francini
H 指数:15论文数:83被引数:635
E
Ella N. Hoogenboezem
H 指数:9论文数:65被引数:823
C
Craig L. Duvall
H 指数:50论文数:267被引数:8,772
M
Matthew Schrag
H 指数:37论文数:160被引数:5,570
K
Ketaki A. Katdare
H 指数:5论文数:20被引数:280
J
Justin H. Lo
H 指数:15论文数:104被引数:1,482
A
Andrew Kjar
H 指数:6论文数:25被引数:327
K
Katrina R Schwensen
H 指数:3论文数:6被引数:15
A
Alena Shostak
H 指数:20论文数:65被引数:3,138