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邹

邹宏斌 (Hongbin Zou)

Soochow University

H指数:27

被引数:1,877

个人简介

"2002年毕业于浙江大学药学系，获学士学位。同年免试攻读浙江大学药学院药物化学专业研究生，师从长江学者赵昱教授，进行活性天然产物的结构改造，2007年获博士学位。2007-2009年进入浙江大学药物研究所俞永平教授课题组从事类药性化合物库构建的博士后研究。2007年至2008年赴德国Mainz大学，跟随著名结构生物学专家Joachim Stockigt 教授从事活性天然产物的生物催化研究。2009年开始在浙江大学药物研究所工作，先后担任讲师、副教授。2013年底至2016年初在美国加州大学圣地亚哥分校Scripps海洋研究所生物合成专家Bradley S. Moore教授实验室访问研究两年，主要从事海洋活性天然产物的生物合成研究，建立了广泛的国际交流合作关系。已主持承担三项国家自然科学基金及多项省部级研究课题，在国际知名期刊Journal of American Chemical Society, ACS Catalysis, Chemical Science, Chemical Communications, Organic Letters, European Journal of Medicinal Chemistry等发表研究论文40余篇；获国家发明专利10余项。2011年入选浙江省钱江人才计划;浙江大学首批求是青年学者。担任Chemical Reviews、Chemical Science、Medicinal Chemistry Review等杂志特邀审稿人。"

教育背景

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工作经历

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荣誉奖项

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Mechanistic insights into midgut injury in Bombyx mori induced by low concentration exposure to Bacillus thuringiensis

家蚕中肠损伤的机制：低浓度苏云金芽孢杆菌暴露诱导

Pesticide Biochemistry and Physiology

IF4

2026-07-010

PRE

FADS-Based Universal Ultra-High-Throughput Evolution of Transaminases Using a Dual-Functional Probe

基于FADS的转氨酶双功能探针通用超高通量定向进化

IF13.1

2026-05-010

PRE

Enhancing the Thermostability of an (R)-Selective ω-Transaminase with Broad Substrate Scope by Integrated Rational Design

通过综合理性设计增强一种具有广泛底物谱的(R)-选择性ω-转氨酶的热稳定性

Journal of Agricultural and Food Chemistry

IF6.2

2026-02-250

PRE

Mechanistic Insights into Anti-Melanogenic Effects of Fisetin: PKCα-Induced β-Catenin Degradation, ERK/MITF Inhibition, and Direct Tyrosinase Suppression

槲皮素抗黑色素生成效应的机制研究：PKCα诱导的β-连环蛋白降解、ERK/MITF抑制及直接酪氨酸酶抑制

International Journal of Molecular Sciences 2025, Vol. 26, Page 11739

IF4.9

2025-12-050

OAAI

Discovery of adamantyl derivatives as potent and selective TRPM2 inhibitors with significantly reduced hERG liability

发现金刚烷衍生物作为具有显著降低hERG毒性的强效且选择性的TRPM2抑制剂。

European Journal of Medicinal Chemistry

IF5.9

2025-09-130

PRE

Asynchronous programmed cell death occurrence in the silk glands at pupation (Bombyx mori)

化蛹时家蚕（Bombyx mori）丝腺中不同步的程序性细胞死亡发生

IF3

2025-08-270

PRE

Discovery of acylsulfenic acid-featuring natural product sulfenicin and characterization of its biosynthesis

酰基亚磺酸特征天然产物sulfenicin的发现及其生物合成特性的表征

NATURE CHEMISTRY

IF20.2

2025-05-200

PRE

Substituents introduction of methyl and methoxy functional groups on resveratrol stabilizes mTOR binding for autophagic cell death induction

在白藜芦醇上引入甲基和甲氧基官能团可稳定mTOR结合，从而诱导自噬性细胞死亡。

SCIENTIFIC REPORTS

IF3.9

2025-04-260

OA

The Mechanism of Damage to the Midgut by Low Concentration of Bacillus thuringiensis in the Silkworm, Bombyx mori

苏云金芽孢杆菌低浓度对家蚕中肠损伤的机制

IF2.9

2024-11-210

OA

A New Renieramycin T Right-Half Analog as a Small Molecule Degrader of STAT3

IF5.4

2024-08-140

OAAI

Correction: Thepthanee et al. Shrimp Lipids Inhibit Migration, Epithelial-Mesenchymal Transition, and Cancer Stem Cells via Akt/mTOR/c-Myc Pathway Suppression. Biomedicines 2024, 12, 722

IF3.9

2024-08-050

OAAI

Shrimp Lipids Inhibit Migration, Epithelial-Mesenchymal Transition, and Cancer Stem Cells via Akt/mTOR/c-Myc Pathway Suppression

IF3.9

2024-03-252

OAAI

Simplified Synthesis of Renieramycin T Derivatives to Target Cancer Stem Cells via β-Catenin Proteasomal Degradation in Human Lung Cancer

IF5.4

2023-11-302

OAAI

Pd-Catalyzed TBHP-Mediated Selective Wacker-Type Oxidation and Oxo-acyloxylation of Olefins Using a 2-(1H-Indazol-1-yl)quinoline

ORGANIC LETTERS

IF5

2023-03-109

PRE

Rh(iii)-catalyzed regioselective versatile indole derivatization: delivering potential of rare β-(1H-indol-2-yl)-β-amino acids in one pot

CHEMICAL COMMUNICATIONS

IF4.2

2023-01-012

PRE

Aza-dicyclopenta[a,g]naphthalenes: controllable seesaw-like emissive behavior and narrowband AIEgens

CHEMICAL SCIENCE

IF7.4

2023-01-010

OAAI

Palladium-Catalyzed Cascade Reaction in Water to Imidazo[1,2-a]pyridazines as Switchable DSEgens, AIEgens, and ACQgens

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2022-10-139

PRE

Novel mechanism of napabucasin, a naturally derived furanonaphthoquinone: apoptosis and autophagy induction in lung cancer cells through direct targeting on Akt/mTOR proteins

BMC COMPLEMENTARY MEDICINE AND THERAPIES

IF3.4

2022-09-308

OAAI

Development and Validation of a Prediction Model for the Cure of Peritoneal Dialysis-Associated Peritonitis: A Multicenter Observational Study

腹膜透析相关性腹膜炎治愈预测模型的建立与验证: 一项多中心观察性研究

FRONTIERS IN MEDICINE

IF3

2022-04-268

OAAI

β-Methyltryptamine Provoking the Crucial Role of Strictosidine Synthase Tyr151-OH for Its Stereoselective Pictet-Spengler Reactions to Tryptoline-type Alkaloids

ACS CHEMICAL BIOLOGY

IF3.8

2022-01-073

PRE