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W

William Lehman

Avedisian School of Medicine

50H指数
250论文数
8.5K被引数
收录论文 101
发表时间
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Pseudo-acetylation of ACTC1 K326 and K328 promotes dysinhibition of reconstituted human cardiac thin filamentsACTC1 K326和K328的伪乙酰化促进重组人 cardiac thin filaments 的去抑制
errJournal of Molecular and Cellular Cardiology
IF4.7
err2025-12-22
err0
errOAAI
errKripa Chitre; Olga E. Karpicheva; Chloe J. King; Michael J. Rynkiewicz; Axel J. Fenwick; John F. Dawson; D. Brian Foster; William Lehman; Anthony Cammarato
err分享
err收藏
Screening single nucleotide changes to tropomyosin to identify novel cardiomyopathy mutants筛查肌动蛋白结合蛋白肌球蛋白轻链激酶（tropomyosin）的单核苷酸变化以识别新型心肌病突变体
errJOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
IF4.7
err2025-06-01
err0
PREAI
errWen (Jake), Jian; Campbell, Stuart; Moore, Jeffrey; Lehman, William; Rynkiewicz, Michael
err分享
err收藏
Velcro-binding by cardiac troponin-I traps tropomyosin on actin in a low-energy relaxed state肌钙蛋白I通过维可牢（Velcro）结合方式将原肌球蛋白锁定在肌动蛋白上的低能量松弛状态。
errBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
IF2.2
err2025-04-01
err0
PREAI
errRamachandran, Balajee; Rynkiewicz, Michael; Lehman, William
err分享
err收藏
Dual role of Tropomyosin-R160 in thin filament regulation: Insights into phosphorylation-dependent cardiac relaxation and cardiomyopathy mechanismsTropomyosin-R160在细丝调节中的双重作用: 对磷酸化依赖性心脏舒张和心肌病机制的见解
errARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
IF3
err2025-03-01
err0
PREAI
errBarry, Meaghan E.; Rynkiewicz, Michael J.; Wen, Jian; Tu, An-Yue; Regnier, Michael; Lehman, William; Moore, Jeffrey R.
err分享
err收藏
The hypertrophic cardiomyopathy-associated A331P actin variant enhances basal contractile activity and elicits resting muscle dysfunction肥厚型心肌病相关的A331P肌动蛋白变体可增强基础收缩活动并引起静息肌肉功能障碍
errISCIENCE
IF4.1
err2025-02-01
err0
errOAAI
errDoran, Matthew H.; Rynkiewicz, Michael J.; Despond, Evan; Viswanathan, Meera C.; Madan, Aditi; Chitre, Kripa; Fenwick, Axel J.; Sousa, Duncan; Lehman, William; Dawson, John F.; Cammarato, Anthony
err分享
err收藏
In silico and in vitro models reveal the molecular mechanisms of hypocontractility caused by TPM1 M8R
errFRONTIERS IN PHYSIOLOGY
IF3.4
err2024-08-30
err0
errOAAI
errCreso, Jenette G.; Gokhan, Ilhan; Rynkiewicz, Michael J.; Lehman, William; Moore, Jeffrey R.; Campbell, Stuart G.
err分享
err收藏
Myosin's powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin
errJOURNAL OF GENERAL PHYSIOLOGY
IF2.9
err2024-04-12
err1
PREAI
errRynkiewicz, Michael J.; Childers, Matthew C.; Karpicheva, Olga E.; Regnier, Michael; Geeves, Michael A.; Lehman, William
err分享
err收藏
Glutamate 139 of tropomyosin is critical for cardiac thin filament blocked-state stabilization
errJOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
IF4.7
err2024-03-01
err4
PREAI
errBarry, Meaghan E.; Rynkiewicz, Michael J.; Pavadai, Elumalai; Viana, Alex; Lehman, William; Moore, Jeffrey R.
err分享
err收藏
Troponin-I-induced tropomyosin pivoting defines thin-filament function in relaxed and active muscle
errJOURNAL OF GENERAL PHYSIOLOGY
IF2.9
err2023-05-30
err8
errOAAI
errLehman, William; Rynkiewicz, Michael J.
err分享
err收藏
Mechanisms of pathogenicity in the hypertrophic cardiomyopathy-associated TPM1 variant S215L
errPNAS NEXUS
IF3.8
err2023-01-21
err8
errOAAI
errHalder, Saiti S.; Rynkiewicz, Michael J.; Creso, Jenette G.; Sewanan, Lorenzo R.; Howland, Lindsey; Moore, Jeffrey R.; Lehman, William; Campbell, Stuart G.
err分享
err收藏
Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin
errJOURNAL OF GENERAL PHYSIOLOGY
IF2.9
err2023-01-12
err10
errOAAI
errDoran, Matthew H. H.; Rynkiewicz, Michael J. J.; Rassici, David; Bodt, Skylar M. L.; Barry, Meaghan E. E.; Bullitt, Esther; Yengo, Christopher M. M.; Moore, Jeffrey R. R.; Lehman, William
err分享
err收藏
Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation
errJOURNAL OF GENERAL PHYSIOLOGY
IF2.9
err2022-12-02
err9
errOAAI
errDoran, Matthew H.; Rynkiewicz, Michael J.; Pavadai, Elumalai; Bodt, Skylar M. L.; Rasicci, David; Moore, Jeffrey R.; Yengo, Christopher M.; Bullitt, Esther; Lehman, William
err分享
err收藏
Modulation of cardiac thin filament structure by phosphorylated troponin-I analyzed by protein-protein docking and molecular dynamics simulation
errARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
IF3
err2022-08-01
err13
errOAAI
errPavadai, Elumalai; Rynkiewicz, Michael J.; Yang, Zeyu; Gould, Ian R.; Marston, Steven B.; Lehman, William
err分享
err收藏
Modeling Human Cardiac Thin Filament Structures
errFRONTIERS IN PHYSIOLOGY
IF3.4
err2022-06-22
err13
errOAAI
errRynkiewicz, Michael J.; Pavadai, Elumalai; Lehman, William
err分享
err收藏
Genetic resiliency associated with dominant lethal TPM1 mutation causing atrial septal defect with high heritability
errCELL REPORTS MEDICINE
IF10.6
err2022-02-01
err4
errOAAI
errTeekakirikul, Polakit; Zhu, Wenjuan; Xu, Xinxiu; Young, Cullen B.; Tan, Tuantuan; Smith, Amanda M.; Wang, Chengdong; Peterson, Kevin A.; Gabriel, George C.; Ho, Sebastian; Sheng, Yi; de Bellaing, Anne Moreau; Sonnenberg, Daniel A.; Lin, Jiuann-huey; Fotiou, Elisavet; Tenin, Gennadiy; Wang, Michael X.; Wu, Yijen L.; Feinstein, Timothy; Devine, William; Gou, Honglan; Bais, Abha S.; Glennon, Benjamin J.; Zahid, Maliha; Wong, Timothy C.; Ahmad, Ferhaan; Rynkiewicz, Michael J.; Lehman, William J.; Keavney, Bernard; Alastalo, Tero-Pekka; Freckmann, Mary-Louise; Orwig, Kyle; Murray, Steve; Ware, Stephanie M.; Zhao, Hui; Feingold, Brian; Lo, Cecilia W.
err分享
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Mavacamten And Danicamtiv Reverse Respective Contractile Abnormalities In Engineered Heart Tissue Models Of Hypertrophic And Dilated Cardiomyopathy
errCIRCULATION RESEARCH
IF16.2
err2021-09-03
err1
PREAI
errHalder, Saiti S.; Sewanan, Lorenzo R.; Rynkiewicz, Michael J.; Moore, Jeffrey R.; Lehman, William J.; Campbell, Stuart G.
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err收藏
Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation
errJOURNAL OF GENERAL PHYSIOLOGY
IF2.9
err2021-07-28
err29
errOAAI
errSewanan, Lorenzo R.; Park, Jinkyu; Rynkiewicz, Michael J.; Racca, Alice W.; Papoutsidakis, Nikolaos; Schwan, Jonas; Jacoby, Daniel L.; Moore, Jeffrey R.; Lehman, William; Qyang, Yibing; Campbell, Stuart G.
err分享
err收藏
M8R tropomyosin mutation disrupts actin binding and filament regulation: The beginning affects the middle and end
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2020-12-01
err12
errOAAI
errRacca, Alice Ward; Rynkiewicz, Michael J.; LaFave, Nicholas; Ghosh, Anita; Lehman, William; Moore, Jeffrey R.
err分享
err收藏
Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments
errBIOPHYSICAL JOURNAL
IF3.1
err2020-08-01
err45
errOAAI
errDoran, Matthew H.; Pavadai, Elumalai; Rynkiewicz, Michael J.; Walklate, Jonathan; Bullitt, Esther; Moore, Jeffrey R.; Regnier, Michael; Geeves, Michael A.; Lehman, William
err分享
err收藏
Protein-Protein Docking Reveals Dynamic Interactions of Tropomyosin on Actin Filaments
errBIOPHYSICAL JOURNAL
IF3.1
err2020-07-01
err37
errOAAI
errPavadai, Elumalai; Lehman, William; Rynkiewicz, Michael J.
err分享
err收藏

研究方向

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