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收藏Mechanistic Characterization of the Potency of THIOMAB Antibody-Drug Conjugates Targeting Staphylococcus aureus and ETbR-Expressing Tumor Cells Using Quantitative LC-MS/MS Analysis of Intracellular Drug Accumulation
Hernandez-Barry, Hilda; dela Cruz-Chuh, Josefa; Kajihara, Kimberly K.; Asundi, Jyoti; Vandlen, Richard; Zhang, Donglu; Hazenbos, Wouter L. W.; Pillow, Thomas; Liu, Yichin; Wu, Cong; Kozak, Katherine R.; Loyet, Kelly M. 分享 收藏 On Demand Bioorthogonal Switching of an Antibody-Conjugated SPECT Probe to a Cytotoxic Payload: from Imaging to TherapyAdhikari, Pragya; Li, Guangmin; Go, Maryann; Mandikian, Danielle; Rafidi, Hanine; Ng, Carl; Anifa, Sagana; Johnson, Kevin; Bao, Linda; Barry, Hilda Hernandez; Rowntree, Rebecca; Agard, Nicholas; Wu, Cong; Chou, Kang-Jye; Zhang, Donglu; Kozak, Katherine R.; Pillow, Thomas H.; Lewis, Gail D.; Yu, Shang-Fan; Boswell, C. Andrew; Sadowsky, Jack D. 分享 收藏 A homogeneous high-DAR antibody-drug conjugate platform combining THIOMAB antibodies and XTEN polypeptidesZacharias, Neelie; Podust, Vladimir N.; Kajihara, Kimberly K.; Leipold, Douglas; Del Rosario, Geoffrey; Thayer, Desiree; Dong, Emily; Paluch, Maciej; Fischer, David; Zheng, Kai; Lei, Corinna; He, Jintang; Ng, Carl; Su, Dian; Liu, Luna; Masih, Shabkhaiz; Sawyer, William; Tinianow, Jeff; Marik, Jan; Yip, Victor; Li, Guangmin; Chuh, Josefa; Morisaki, J. Hiroshi; Park, Summer; Zheng, Bing; Hernandez-Barry, Hilda; Loyet, Kelly M.; Xu, Min; Kozak, Katherine R.; Phillips, Gail Lewis; Shen, Ben-Quan; Wu, Cong; Xu, Keyang; Yu, Shang-Fan; Kamath, Amrita; Rowntree, Rebecca K.; Reilly, Dorothea; Pillow, Thomas; Polson, Andrew; Schellenberger, Volker; Hazenbos, Wouter L. W.; Sadowsky, Jack 分享 收藏 Calicheamicin Antibody-Drug Conjugates with Improved PropertiesVollmar, Breanna S.; Frantz, Chris; Schutten, Melissa M.; Zhong, Fiona; Rosario, Geoffrey del; Go, Mary Ann T.; Yu, Shang-Fan; Leipold, Douglas D.; Kamath, Amrita, V; Ng, Carl; Xu, Keyang; Cruz-Chuh, Josefa Dela; Kozak, Katherine R.; Chen, Jinhua; Xu, Zijin; Wai, John; Adhikari, Pragya; Erickson, Hans K.; Dragovich, Peter S.; Polson, Andrew G.; Pillow, Thomas H. 分享 收藏 Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties嵌合BRD4降解剂的抗体介导递送。第1部分: 抗体接头，有效载荷加载和有效载荷分子特性的探索Dragovich, Peter S.; Pillow, Thomas H.; Blake, Robert A.; Sadowsky, Jack D.; Adaligil, Emel; Adhikari, Pragya; Bhakta, Sunil; Blaquiere, Nicole; Chen, Jinhua; Dela Cruz-Chuh, Josefa; Gascoigne, Karen E.; Hartman, Steven J.; He, Mingtao; Kaufman, Susan; Kleinheinz, Tracy; Kozak, Katherine R.; Liu, Liang; Liu, Liling; Liu, Qi; Lu, Ying; Meng, Fanwei; Mulvihill, Melinda M.; O'Donohue, Aimee; Rowntree, Rebecca K.; Staben, Leanna R.; Staben, Steven T.; Wai, John; Wang, Jian; Wei, BinQing; Wilson, Catherine; Xin, Jianfeng; Xu, Zijin; Yao, Hui; Zhang, Donglu; Zhang, Hongyan; Zhou, Hao; Zhu, Xiaoyu 分享 收藏 Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy嵌合BRD4降解剂的抗体介导递送。第2部分: 体外抗增殖活性和体内抗肿瘤功效的提高Dragovich, Peter S.; Pillow, Thomas H.; Blake, Robert A.; Sadowsky, Jack D.; Adaligil, Emel; Adhikari, Pragya; Chen, Jinhua; Corr, Nicholas; Dela Cruz-Chuh, Josefa; Del Rosario, Geoffrey; Fullerton, Aaron; Hartman, Steven J.; Jiang, Fan; Kaufman, Susan; Kleinheinz, Tracy; Kozak, Katherine R.; Liu, Liling; Lu, Ying; Mulvihill, Melinda M.; Murray, Jeremy M.; O'Donohue, Aimee; Rowntree, Rebecca K.; Sawyer, William S.; Staben, Leanna R.; Wai, John; Wang, Jian; Wei, BinQing; Wei, Wentao; Xu, Zijin; Yao, Hui; Yu, Shang-Fan; Zhang, Donglu; Zhang, Hongyan; Zhang, Shenhua; Zhao, Yongxin; Zhou, Hao; Zhu, Xiaoyu 分享 收藏 Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor responseDela Cruz Chuh, Josefa; Go, MaryAnn; Chen, Yvonne; Guo, Jun; Rafidi, Hanine; Mandikian, Danielle; Sun, Yonglian; Lin, Zhonghua; Schneider, Kellen; Zhang, Pamela; Vij, Rajesh; Sharpnack, Danielle; Chan, Pamela; de la Cruz, Cecile; Sadowsky, Jack; Seshasayee, Dhaya; Koerber, James T.; Pillow, Thomas H.; Phillips, Gail D.; Rowntree, Rebecca K.; Boswell, C. Andrew; Kozak, Katherine R.; Polson, Andrew G.; Polakis, Paul; Yu, Shang-Fan; Dragovich, Peter S.; Agard, Nicholas J. 分享 收藏 Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug ConjugatesStaben, Leanna R.; Chen, Jinhua; dela Cruz-Chuh, Josefa; del Rosario, Geoff; Go, Mary Ann; Guo, Jun; Khojasteh, S. Cyrus; Kozak, Katherine R.; Li, Guangmin; Ng, Carl; Phillips, Gail D. Lewis; Pillow, Thomas H.; Rowntree, Rebecca K.; Wai, John; Wei, BinQing; Xu, Keyang; Xu, Zijin; Yu, Shang-Fan; Zhang, Donglu; Dragovich, Peter S. 分享 收藏 Improved translation of stability for conjugated antibodies using an in vitro whole blood assayFourie-O'Donohue, Aimee; Chu, Phillip Y.; Chuh, Josefa dela Cruz; Tchelepi, Robert; Tsai, Siao Ping; Tran, John C.; Sawyer, William S.; Su, Dian; Ng, Carl; Xu, Keyang; Yu, Shang-Fan; Pillow, Thomas H.; Sadowsky, Jack; Dragovich, Peter S.; Liu, Yichin; Kozak, Katherine R. 分享 收藏 Development of a Cysteine-Conjugatable Disulfide FRET Probe: Influence of Charge on Linker Cleavage and Payload Trafficking for an Anti-HER2 Antibody ConjugateScales, Suzie J.; Tsai, Siao Ping; Zacharias, Neelie; dela Cruz-Chuh, Josefa; Bullen, Gordy; Velasquez, Erick; Chang, Julie; Bruguera, Elise; Kozak, Katherine R.; Sadowsky, Jack 分享 收藏 Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity嵌合BET降解剂的抗体偶联可实现体内活性Pillow, Thomas H.; Adhikari, Pragya; Blake, Robert A.; Chen, Jinhua; Del Rosario, Geoffrey; Deshmukh, Gauri; Figueroa, Isabel; Gascoigne, Karen E.; Kamath, Amrita, V; Kaufman, Susan; Kleinheinz, Tracy; Kozak, Katherine R.; Latifi, Brandon; Leipold, Douglas D.; Li, Chun Sing; Li, Ruina; Mulvihill, Melinda M.; O'Donohue, Aimee; Rowntree, Rebecca K.; Sadowsky, Jack D.; Wai, John; Wang, Xinxin; Wu, Cong; Xu, Zijin; Yao, Hui; Yu, Shang-Fan; Zhang, Donglu; Zang, Richard; Zhang, Hongyan; Zhou, Hao; Zhu, Xiaoyu; Dragovich, Peter S. 分享 收藏 An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer (vol 17, pg 638, 2018)Bhakta, Sunil; Crocker, Lisa M.; Chen, Yvonne; Hazen, Meredith; Schutten, Melissa M.; Li, Dongwei; Kuijl, Coenraad; Ohri, Rachana; Zhong, Fiona; Poon, Kirsten A.; Go, Mary Ann T.; Cheng, Eric; Piskol, Robert; Firestein, Ron; Fourie-O'Donohue, Aimee; Kozak, Katherine R.; Raab, Helga; Hongo, Jo-Anne; Sampath, Deepak; Dennis, Mark S.; Scheller, Richard H.; Polakis, Paul; Junutula, Jagath R. 分享 收藏 Evaluation and use of an anti-cynomolgus monkey CD79b surrogate antibody-drug conjugate to enable clinical development of polatuzumab vedotinLi, Dongwei; Lee, Donna; Dere, Randall C.; Zheng, Bing; Yu, Shang-Fan; Fuh, Franklin K.; Kozak, Katherine R.; Chung, Shan; Yadav, Daniela Bumbaca; Nazzal, Denise; Danilenko, Dimitry; Go, Mary Ann T.; Williams, Marna; Polson, Andrew G.; Poon, Kirsten Achilles; Prabhu, Saileta 分享 收藏 Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In VivoSu, Dian; Chen, Jinhua; Cosino, Ely; dela Cruz-Chuh, Josefa; Davis, Helen; Del Rosario, Geoffrey; Figueroa, Isabel; Goon, Leanne; He, Jintang; Kamath, Amrita V.; Kaur, Surinder; Kozak, Katherine R.; Lau, Jeffrey; Lee, Donna; Lee, M. Violet; Leipold, Douglas; Liu, Luna; Liu, Peter; Lu, Guo-Liang; Nelson, Chris; Ng, Carl; Pillow, Thomas H.; Polakis, Paul; Polson, Andrew G.; Rowntree, Rebecca K.; Saad, Ola; Safina, Brian; Stagg, Nicola J.; Tercel, Moana; Vandlen, Richard; Vollmar, Breanna S.; Wai, John; Wang, Tao; Wei, BinQing; Xu, Keyang; Xue, Juanjuan; Xu, Zijin; Yan, Gang; Yao, Hui; Yu, Shang-Fan; Zhang, Donglu; Zhong, Fiona; Dragovich, Peter S. 分享 收藏 Development, Optimization, and Structural Characterization of an Efficient Peptide-Based Photoaffinity Cross-Linking Reaction for Generation of Homogeneous Conjugates from Wild-Type AntibodiesVance, Nicholas; Zacharias, Neelie; Ultsch, Mark; Li, Guangmin; Fourie, Aimee; Liu, Peter; LaFrance-Vanasse, Julien; Ernst, James A.; Sandoval, Wendy; Kozak, Katherine R.; Phillips, Gail; Wang, Weiru; Sadowsky, Jack 分享 收藏 Preclinical pharmacokinetics and pharmacodynamics of DCLL9718A: An antibody-drug conjugate for the treatment of acute myeloid leukemiaLeipold, Douglas D.; Figueroa, Isabel; Masih, Shabkhaiz; Latifi, Brandon; Yip, Victor; Shen, Ben-Quan; Dere, Randall C.; Carrasco-Triguero, Montserrat; Lee, M. Violet; Saad, Ola M.; Liu, Luna; He, Jintang; Su, Dian; Xu, Keyang; Vuillemenot, Brian R.; Laing, Steven T.; Schutten, Melissa; Kozak, Katherine R.; Zheng, Bing; Polson, Andrew G.; Kamath, Amrita V. 分享 收藏 FRET Reagent Reveals the Intracellular Processing of Peptide-Linked Antibody-Drug ConjugatesLee, Byoung-Chul; Chalouni, Cecile; Doll, Sophia; Nalle, Sam C.; Darwish, Martine; Tsai, Siao Ping; Kozak, Katherine R.; Del-Rosario, Geoffrey; Yu, Shang-Fan; Erickson, Hans; Vandlen, Richard 分享 收藏 分享 收藏 Prediction of non-linear pharmacokinetics in humans of an antibody-drug conjugate (ADC) when evaluation of higher doses in animals is limited by tolerability: Case study with an anti-CD33 ADCFigueroa, Isabel; Leipold, Doug; Leong, Steve; Zheng, Bing; Triguero-Carrasco, Montserrat; Fourie-O'Donohue, Aimee; Kozak, Katherine R.; Xu, Keyang; Schutten, Melissa; Wang, Hong; Polson, Andrew G.; Kamath, Amrita V. 分享 收藏 
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