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G

Giuseppe Melacini

mcmaster university

42H指数
171论文数
5.0K被引数
收录论文 97
发表时间
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A cryptic symmetry switch allosterically controls how the PF4 self-protein turns into a pathogenic antigen隐秘的对称性开关通过别构方式控制PF4自体蛋白如何转变为致病性抗原
errNature Communications
IF15.7
err2026-09-11
err0
errOAAI
errQiulin Ma; Jinfeng Huang; Ellen Mak; Karla Martinez Pomier; Pengxiao Zhou; Madoka Akimoto; Nikola Ivetic; Ishac Nazy; Giuseppe Melacini
err分享
err收藏
Aortic disease-linked mutations reveal unexpected convergent allosteric mechanisms of protein kinase G misregulation主动脉疾病相关突变揭示了蛋白激酶G失调的意外趋同别构机制
errScience Advances
IF12.5
err2026-09-02
err0
errOAAI
errKarla Martinez Pomier; Leopold Jahn; Bryan VanSchouwen; Hebatallah Mohamed; Madoka Akimoto; Sun Woo Jung; Daniela Bertinetti; Johannes Mehringer; Leonardo Della Libera; Friederike Cuello; Friedrich W. Herberg; Giuseppe Melacini
err分享
err收藏
Resonance assignments of asymmetric tetrameric platelet factor 4 (PF4)不对称四聚体血小板因子4（PF4）的共振分配
errBIOMOLECULAR NMR ASSIGNMENTS
IF0.6
err2025-09-01
err0
PREAI
errMa, Qiulin; Huang, Jinfeng; Boulton, Stephen; Mak, Ellen; Akimoto, Madoka; Giraldo, Estefania Lopez; Truong, Mikayla; Daka, Mercy; Huynh, Angela; Kwok, Sarah; Clare, Rumi; Nazy, Ishac; Lee, Woonghee; Melacini, Giuseppe
err分享
err收藏
Recurrent Acrodysostosis-Related PKA RIα Mutant Reveals a Novel Mechanism of Aberrant PKA Deactivation复发性肢端骨发育不全相关PKA RIα突变体揭示了PKA异常失活的一种新机制
errJournal of Molecular Biology
IF4.5
err2025-08-09
err0
errOAAI
errLeonardo Della Libera; Karla Martinez Pomier; Madoka Akimoto; Ganesh S. Anand; Susan S. Taylor; Giuseppe Melacini
err分享
err收藏
Unbiased clustering of residues undergoing synchronous motions in proteins using NMR spin relaxation data使用NMR自旋弛豫数据对蛋白质中经历同步运动的残基进行无偏聚类
errBIOPHYSICAL CHEMISTRY
IF2.2
err2025-05-01
err0
PREAI
errManu, V. S.; Melacini, Giuseppe; Kovrigin, Evgenii L.; Loria, J. Patrick; Veglia, Gianluigi
err分享
err收藏
Amyloid-Driven Allostery
errBIOPHYSICAL CHEMISTRY
IF2.2
err2024-12-01
err0
errOAAI
errGarcha, Jaskiran; Huang, Jinfeng; Pomier, Karla Martinez; Melacini, Giuseppe
err分享
err收藏
Inhibition of toxic metal-alpha synuclein interactions by human serum albumin
errCHEMICAL SCIENCE
IF7.4
err2024-01-01
err3
errOAAI
errPomier, Karla Martinez; Ahmed, Rashik; Huang, Jinfeng; Melacini, Giuseppe
err分享
err收藏
Probing ligand selectivity in pathogens
errELIFE
IF0
err2023-12-21
err1
errOAAI
errVanSchouwen, Bryan; Melacini, Giuseppe
err分享
err收藏
Early-Onset Parkinson Mutation Remodels Monomer-Fibril Interactions to Allosterically Amplify Synuclein's Amyloid Cascade
errJACS AU
IF8.7
err2023-12-13
err2
errOAAI
errHuang, Jinfeng; Ahmed, Rashik; Akimoto, Madoka; Pomier, Karla Martinez; Melacini, Giuseppe
err分享
err收藏
Fractionation factors reveal hidden frustration in an ancient allosteric module
errJOURNAL OF CHEMICAL PHYSICS
IF3.1
err2023-03-28
err2
errOAAI
errVanSchouwen, Bryan; Della Libera, Leonardo; Melacini, Giuseppe
err分享
err收藏
Toward a molecular mechanism for the interaction of ATP with alpha-synuclein
errCHEMICAL SCIENCE
IF7.4
err2023-01-01
err6
errOAAI
errKamski-Hennekam, Evelyn Rose; Huang, Jinfeng; Ahmed, Rashik; Melacini, Giuseppe
err分享
err收藏
An auto-inhibited state of protein kinase G and implications for selective activation蛋白激酶G的自动抑制状态及其对选择性激活的影响
errELIFE
IF0
err2022-08-05
err3
errOAAI
errSharma, Rajesh; Kim, Jeong Joo; Qin, Liying; Henning, Philipp; Akimoto, Madoka; VanSchouwen, Bryan; Kaur, Gundeep; Sankaran, Banumathi; MacKenzie, Kevin R.; Melacini, Giuseppe; Casteel, Darren E.; Herberg, Friedrich W.; Kim, Choel
err分享
err收藏
Identification of core allosteric sites through temperature- and nucleus-invariant chemical shift covariance
errBIOPHYSICAL JOURNAL
IF3.1
err2022-06-01
err3
errOAAI
errMohamed, Hebatallah; Baryar, Ubaidullah; Bashiri, Amir; Selvaratnam, Rajeevan; VanSchouwen, Bryan; Melacini, Giuseppe
err分享
err收藏
Allosteric pluripotency: challenges and opportunities
errBIOCHEMICAL JOURNAL
IF4.3
err2022-04-11
err6
PREAI
errAkimoto, Madoka; Pomier, Karla Martinez; VanSchouwen, Bryan; Byun, Jung Ah; Khamina, Mariia; Melacini, Giuseppe
err分享
err收藏
Interactions of intrinsically disordered proteins with the unconventional chaperone human serum albumin: From mechanisms of amyloid inhibition to therapeutic opportunities
errBIOPHYSICAL CHEMISTRY
IF2.2
err2022-03-01
err13
PREAI
errPomier, Karla Martinez; Ahmed, Rashik; Melacini, Giuseppe
err分享
err收藏
Structural determinants of the interactions of catechins with Aβ oligomers and lipid membranes
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2022-02-01
err7
errOAAI
errAhmed, Rashik; Huang, Jinfeng; Lifshitz, Romi; Pomier, Karla Martinez; Melacini, Giuseppe
err分享
err收藏
QSAR models reveal new EPAC-selective allosteric modulators
errRSC CHEMICAL BIOLOGY
IF3.1
err2022-01-01
err3
errOAAI
errMohamed, Hebatallah; Shao, Hongzhao; Akimoto, Madoka; Darveau, Patrick; MacKinnon, Marc R.; Magolan, Jakob; Melacini, Giuseppe
err分享
err收藏
Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2021-05-18
err13
errOAAI
errJafari, Naeimeh; Del Rio, Jason; Akimoto, Madoka; Byun, Jung Ah; Boulton, Stephen; Moleschi, Kody; Alsayyed, Yousif; Swanson, Pascale; Huang, Jinfeng; Pomier, Karla Martinez; Lee, Chi; Wu, Jian; Taylor, Susan S.; Melacini, Giuseppe
err分享
err收藏
Atomic Resolution Map of Hierarchical Self-Assembly for an Amyloidogenic Protein Probed through Thermal 15N-R2 Correlation Matrices
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2021-03-18
err12
PREAI
errAhmed, Rashik; Huang, Jinfeng; Akimoto, Madoka; Shi, Tongyu; Melacini, Giuseppe
err分享
err收藏
α-Synuclein and neuronal membranes: Conformational flexibilities in health and disease
errCHEMISTRY AND PHYSICS OF LIPIDS
IF2.8
err2021-03-01
err9
PREAI
errBozelli, Jose Carlos, Jr.; Kamski-Hennekam, Evelyn; Melacini, Giuseppe; Epand, Richard M.
err分享
err收藏

研究方向

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合作学者
合作期刊
S
Susan S. Taylor
H 指数: 110 · 论文数: 715
J
John D. Scott
H 指数: 104 · 论文数: 439
R
Richard M. Epand
H 指数: 98 · 论文数: 784
R
Rodolfo Ghirlando
H 指数: 74 · 论文数: 273
K
Karen Mossman
H 指数: 68 · 论文数: 241
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