Carmela Molinaro - Publications, H-index & Citations

Development of a First-Generation Stereocontrolled Manufacturing Process of TRPA1 Inhibitor GDC-6599

IF3.5

2024-07-22

PREAI

Molinaro, Carmela; Wong, Nicholas; White, Nicholas A.; Sirois, Lauren E.; Bigler, Raphael; Bindschaedler, Quentin P.; Do, Steven; Malhotra, Sushant; Gosselin, Francis

Asymmetric Synthesis of N-Alkyl Amino Acids through a Biocatalytic Dynamic Kinetic Resolution of PEGylated N-Alkyl Amino Esters

IF3.5

2024-05-24

PREAI

Hong, Allen Y.; Piechowicz, Katarzyna A.; Timmerman, Jacob C.; Zhang, Haiming; Molinaro, Carmela; Gosselin, Francis

Practical Synthesis of Reactive Immuno-PET Linker-Chelator (1R,2R)-RESCA-TFP

IF5

2023-12-05

PREAI

Molinaro, Carmela; Kelly, Sean; Tang, Allison; Iding, Hans; Stocker, Patrik; Xin, Linghu; Gosselin, Francis

Engineered Cytochrome P450-Catalyzed Oxidative Biaryl Coupling Reaction Provides a Scalable Entry into Arylomycin Antibiotics

IF3.5

2023-06-28

PREAI

Wong, Nicholas; Zhao, Eileen; Bao, Jiangyin; Koenig, Stefan G.; Molinaro, Carmela; Timmerman, Jacob C.; Zhang, Haiming; Sowell, C. Gregory; Gosselin, Francis

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2022-07-29

PREAI

Molinaro, Carmela; Kawasaki, Yukie; Wanyoike, George; Nishioka, Taiki; Yamamoto, Tsuyoshi; Snedecor, Brad; Robinson, Sarah J.; Gosselin, Francis

Stereocontrolled Synthesis of Arylomycin-Based Gram-Negative Antibiotic GDC-5338

Preparation of 2-(2H-Tetrazol-2-yl)benzoic Acids via Regioselective Cu(I) Catalyzed N2 Arylation of Tetrazole

IF5

2019-10-31

PREAI

Wong, Nicholas; Petronijevic, Filip; Hong, Allen Y.; Xin Linghu; Kelly, Sean M.; Hou, Haiyun; Cravillion, Theresa; Lim, Ngiap-Kie; Robinson, Sarah J.; Han, Chong; Molinaro, Carmela; Sowell, C. Gregory; Gosselin, Francis

Synthesis of a CGRP Receptor Antagonist via an Asymmetric Synthesis of 3-Fluoro-4-aminopiperidine

IF3.5

2019-09-30

PREAI

Song, Zhiguo Jake; Maligres, Peter; Molinaro, Carmela; Humphrey, Guy; Fritzen, Jeff; Wilson, Jonathan; Chen, Yonggang

Synthesis of Verubecestat, a BACE1 Inhibitor for the Treatment of Alzheimer's Disease

IF3.6

2019-05-24

PREAI

Molinaro, Carmela; Phillips, Eric M.; Xiang, Bangping; Milczek, Erika; Shevlin, Michael; Balsells, Jaume; Ceglia, Scott; Chen, Jiahui; Chen, Lu; Chen, Qinghao; Fei, Zhongbo; Hoerrner, Scott; Qi, Ji; Ruiz, Manuel de Lera; Tan, Lushi; Wan, Baoqiang; Yin, Jingjun

Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group

IF5

2016-11-04

PREAI

Thaisrivongs, David K.; Miller, Steven P.; Molinaro, Carmela; Chen, Qinghao; Song, Zhiguo J.; Tan, Lushi; Chen, Lu; Chen, Wenyong; Lekhal, Azzeddine; Pulicare, Sarah K.; Xu, Yanke

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2016-05-11

OAAI

Bungard, Christopher J.; Williams, Peter D.; Ballard, Jeanine E.; Bennett, David J.; Beaulieu, Christian; Bahnck-Teets, Carolyn; Carroll, Steve S.; Chang, Ronald K.; Dubost, David C.; Fay, John F.; Diamond, Tracy L.; Greshock, Thomas J.; Hao, Li; Holloway, M. Katharine; Felock, Peter J.; Gesell, Jennifer J.; Su, Hua-Poo; Manikowski, Jesse J.; McKay, Daniel J.; Miller, Mike; Min, Xu; Molinaro, Carmela; Moradei, Oscar M.; Nantermet, Philippe G.; Nadeau, Christian; Sanchez, Rosa I.; Satyanarayana, Tummanapalli; Shipe, William D.; Singh, Sanjay K.; Vouy Linh Truong; Vijayasaradhi, Sivalenka; Wiscount, Catherine M.; Vacca, Joseph P.; Crane, Sheldon N.; McCauley, John A.

Synthesis of Free NH 2-(Aminomethyl)indoles through Copper-Catalyzed Reaction of 3-(ortho-Trifluoroacetamidophenyl)-1-propargylic Alcohols with Amines and Palladium/Copper-Cocatalyzed Domino Three-Component Sonogashira Cross-Coupling/Cyclization/Substitution Reactions

ADVANCED SYNTHESIS & CATALYSIS

IF4

2015-03-12

PREAI

Cacchi, Sandro; Fabrizi, Giancarlo; Iazzetti, Antonia; Molinaro, Carmela; Verdiglione, Rosanna; Goggiamani, Antonella

Catalytic, Asymmetric, and Stereodivergent Synthesis of Non-Symmetric β,β-Diaryl-α-Amino Acids

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2015-01-07

100

PREAI

Molinaro, Carmela; Scott, Jeremy P.; Shevlin, Michael; Wise, Christopher; Menard, Alain; Gibb, Andrew; Junker, Ellyn M.; Lieberman, David

Palladium-Catalyzed Synthesis of 2-(Aminomethyl)indoles from 3-(o-Trifluoroacetamidoaryl)-1-propargylic Alcohols and Amines

Reaction of Nitrosonium Cation with Resorc[4]arenes Activated by Supramolecular Control: Covalent Bond Formation

IF3.6

2013-12-18

PREAI

Cacchi, Sandro; Fabrizi, Giancarlo; Goggiamani, Antonella; Molinaro, Carmela; Verdiglione, Rosanna

Introducing Enantioselective Ultrahigh-Pressure Liquid Chromatography (eUHPLC): Theoretical Inspections and Ultrafast Separations on a New Sub-2-μm Whelk-O1 Stationary Phase

IF3.6

2013-07-03

PREAI

Ghirga, Francesca; D'Acquarica, Ilaria; Delle Monache, Giuliano; Mannina, Luisa; Molinaro, Carmela; Nevola, Laura; Sobolev, Anatoly P.; Pierini, Marco; Botta, Bruno

ANALYTICAL CHEMISTRY

IF6.7

2012-07-09

PREAI

Kotoni, Dorina; Ciogli, Alessia; Molinaro, Carmela; D'Acquarica, Ilaria; Kocergin, Jelena; Szczerba, Ted; Ritchie, Harald; Villani, Claudio; Gasparrini, Francesco

CRTH2 Antagonist MK-7246: A Synthetic Evolution from Discovery through Development

A Practical Synthesis of Renin Inhibitor MK-1597 (ACT-178882) via Catalytic Enantioselective Hydrogenation and Epimerization of Piperidine Intermediate (vol 76, pg 1062, 2011)

IF3.6

2012-02-15

113

PREAI

Molinaro, Carmela; Bulger, Paul G.; Lee, Ernest E.; Kosjek, Birgit; Lau, Stephen; Gauvreau, Danny; Howard, Melissa E.; Wallace, Debra J.; O'Shea, Paul D.

Preparative Scale Synthesis of the Biaryl Core of Anacetrapib via a Ruthenium-Catalyzed Direct Arylation Reaction: Unexpected Effect of Solvent Impurity on the Arylation Reaction

IF3.6

2011-12-21

OAAI

Molinaro, Carmela; Shultz, Scott; Roy, Amelie; Lau, Stephen; Trinh, Thao; Angelaud, Remy; O'Shea, Paul D.; Abele, Stefan; Cameron, Mark; Corley, Ed; Funel, Jacques-Alexis; Steinhuebel, Dietrich; Weisel, Mark; Krska, Shane

A Practical Synthesis of Renin Inhibitor MK-1597 (ACT-178882) via Catalytic Enantioselective Hydrogenation and Epimerization of Piperidine Intermediate

IF3.6

2011-02-01

PREAI

Ouellet, Stephane G.; Roy, Amelie; Molinaro, Carmela; Angelaud, Remy; Marcoux, Jean-Francois; O'Shea, Paul D.; Davies, Ian W.

Resolution of 2,2-Disubstituted Epoxides via Biocatalytic Azidolysis

IF3.6

2011-01-20

PREAI